Anti-inflammatory Activity of Elephantopus scaber and Sauropus androgynus Combination in Pregnant Mice Infected with Escherichia coli
The current study aimed to investigate the effectiveness of Elephantopus scaber and Sauropus androgynus as anti-inflammatory agents in pregnant mice infected with Escherichia coli. This study used seven treatments group (n=3): K- (healthy pregnant mice), K+ (pregnant mice infected with E. coli), P1...
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| Format: | Article |
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University of Brawijaya
2022-10-01
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| Series: | Journal of Experimental Life Science |
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| Online Access: | https://jels.ub.ac.id/index.php/jels/article/view/487 |
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| author | Nida Asfi Yuyun Ika Christina Dinia Rizqi Dwijayanti Muhaimin Rifa’i Muhammad Sasmito Djati |
| author_facet | Nida Asfi Yuyun Ika Christina Dinia Rizqi Dwijayanti Muhaimin Rifa’i Muhammad Sasmito Djati |
| author_sort | Nida Asfi |
| collection | DOAJ |
| description | The current study aimed to investigate the effectiveness of Elephantopus scaber and Sauropus androgynus as anti-inflammatory agents in pregnant mice infected with Escherichia coli. This study used seven treatments group (n=3): K- (healthy pregnant mice), K+ (pregnant mice infected with E. coli), P1 (pregnant mice infected with E. coli + E. scaber 100%), P2 (pregnant mice infected with E. coli + E. scaber 75% and S. androgynus 25%), P3 (pregnant mice infected with E. coli + E. scaber 50% and S. androgynus 50%), P4 (pregnant mice infected with E. coli + E. scaber 25% and S. androgynus 75%), P5 (pregnant mice infected with E. coli + S. androgynus 100%). Flow cytometry analysis was used to analyze cell populations expressing CD4+TNFα+, CD4+IFNγ+ and regulatory T cells (CD4+CD25+CD62L+). All treatment groups significantly (p<0.05) decreased TNFα and IFNγ levels, while the P2 group was more effective in increasing regulatory T cells at the 1st and 2nd trimesters of the pregnancy. This study showed that E. scaber and S. androgynus combination alleviated inflammation by reducing inflammatory cytokines (TNFα and IFNγ) and increasing T-regulatory cells. Therefore, E. scaber and S. androgynus combination could suppress the inflammation during pregnancy and infection. |
| format | Article |
| id | doaj-art-9cedfc95315940b7a0aa281c1bb0429d |
| institution | DOAJ |
| issn | 2087-2852 2338-1655 |
| language | English |
| publishDate | 2022-10-01 |
| publisher | University of Brawijaya |
| record_format | Article |
| series | Journal of Experimental Life Science |
| spelling | doaj-art-9cedfc95315940b7a0aa281c1bb0429d2025-08-20T03:09:23ZengUniversity of BrawijayaJournal of Experimental Life Science2087-28522338-16552022-10-01123117123https://doi.org/10.21776/ub.jels.2022.012.03.06Anti-inflammatory Activity of Elephantopus scaber and Sauropus androgynus Combination in Pregnant Mice Infected with Escherichia coliNida Asfi0Yuyun Ika Christina1Dinia Rizqi Dwijayanti2Muhaimin Rifa’i3Muhammad Sasmito Djati4Department of Biology, Universitas BrawijayaDepartment of Biology, Universitas Brawijaya Universitas BrawijayaUniversitas BrawijayaDepartment of Biology, Universitas BrawijayaThe current study aimed to investigate the effectiveness of Elephantopus scaber and Sauropus androgynus as anti-inflammatory agents in pregnant mice infected with Escherichia coli. This study used seven treatments group (n=3): K- (healthy pregnant mice), K+ (pregnant mice infected with E. coli), P1 (pregnant mice infected with E. coli + E. scaber 100%), P2 (pregnant mice infected with E. coli + E. scaber 75% and S. androgynus 25%), P3 (pregnant mice infected with E. coli + E. scaber 50% and S. androgynus 50%), P4 (pregnant mice infected with E. coli + E. scaber 25% and S. androgynus 75%), P5 (pregnant mice infected with E. coli + S. androgynus 100%). Flow cytometry analysis was used to analyze cell populations expressing CD4+TNFα+, CD4+IFNγ+ and regulatory T cells (CD4+CD25+CD62L+). All treatment groups significantly (p<0.05) decreased TNFα and IFNγ levels, while the P2 group was more effective in increasing regulatory T cells at the 1st and 2nd trimesters of the pregnancy. This study showed that E. scaber and S. androgynus combination alleviated inflammation by reducing inflammatory cytokines (TNFα and IFNγ) and increasing T-regulatory cells. Therefore, E. scaber and S. androgynus combination could suppress the inflammation during pregnancy and infection.https://jels.ub.ac.id/index.php/jels/article/view/487elephantopus scaberimmune systeminfectioninflammationsauropus androgynous. |
| spellingShingle | Nida Asfi Yuyun Ika Christina Dinia Rizqi Dwijayanti Muhaimin Rifa’i Muhammad Sasmito Djati Anti-inflammatory Activity of Elephantopus scaber and Sauropus androgynus Combination in Pregnant Mice Infected with Escherichia coli Journal of Experimental Life Science elephantopus scaber immune system infection inflammation sauropus androgynous. |
| title | Anti-inflammatory Activity of Elephantopus scaber and Sauropus androgynus Combination in Pregnant Mice Infected with Escherichia coli |
| title_full | Anti-inflammatory Activity of Elephantopus scaber and Sauropus androgynus Combination in Pregnant Mice Infected with Escherichia coli |
| title_fullStr | Anti-inflammatory Activity of Elephantopus scaber and Sauropus androgynus Combination in Pregnant Mice Infected with Escherichia coli |
| title_full_unstemmed | Anti-inflammatory Activity of Elephantopus scaber and Sauropus androgynus Combination in Pregnant Mice Infected with Escherichia coli |
| title_short | Anti-inflammatory Activity of Elephantopus scaber and Sauropus androgynus Combination in Pregnant Mice Infected with Escherichia coli |
| title_sort | anti inflammatory activity of elephantopus scaber and sauropus androgynus combination in pregnant mice infected with escherichia coli |
| topic | elephantopus scaber immune system infection inflammation sauropus androgynous. |
| url | https://jels.ub.ac.id/index.php/jels/article/view/487 |
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