Novel insights on post-translational modifications of nucleic acid methylation proteins in hepatic fibrosis
Hepatic fibrosis is a pathologic state in which there is an excessive accumulation of the extracellular matrix (ECM) components within the liver parenchyma. It is an ongoing process that compromises the structure and functional performance of the liver tissue. Without treatment, it may progress to e...
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Elsevier
2025-08-01
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| Series: | Pharmacological Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1043661825002506 |
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| author | Wen-Jie Sun Ming-Hui Li Yang Yang Qi-Qi Dong Hui Tao Chao Lu Jing-Jing Yang |
| author_facet | Wen-Jie Sun Ming-Hui Li Yang Yang Qi-Qi Dong Hui Tao Chao Lu Jing-Jing Yang |
| author_sort | Wen-Jie Sun |
| collection | DOAJ |
| description | Hepatic fibrosis is a pathologic state in which there is an excessive accumulation of the extracellular matrix (ECM) components within the liver parenchyma. It is an ongoing process that compromises the structure and functional performance of the liver tissue. Without treatment, it may progress to end-stage liver disease, including cirrhosis and hepatocellular carcinoma. The pathogenesis of hepatic fibrosis involves complex interactions between activated hepatic stellate cells (HSCs), inflammatory mediators, and angiogenic factors, which are regulated by epigenetic modifications and aberrations in signaling pathways. Recent advances highlight the emerging role of post-translational modifications (PTMs) of nucleic acid methylation protein regulators in the pathogenesis of hepatic fibrosis. These modifications affect gene expression and are critical in the development of hepatic fibrosis. This article recapitulates the existing research evidence, analyses the roles of DNA and RNA methylation, as well as their protein regulator PTMs, in hepatic fibrosis, and explains the impact of these modifications on hepatic fibrosis progression. Besides, this article considers the promising implication of these findings to launch new therapeutic strategies, providing a new perspective and direction for treating hepatic fibrosis. |
| format | Article |
| id | doaj-art-9cea4a76eb74448e8c8cd3e9baf64220 |
| institution | DOAJ |
| issn | 1096-1186 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research |
| spelling | doaj-art-9cea4a76eb74448e8c8cd3e9baf642202025-08-20T02:45:42ZengElsevierPharmacological Research1096-11862025-08-0121810782510.1016/j.phrs.2025.107825Novel insights on post-translational modifications of nucleic acid methylation proteins in hepatic fibrosisWen-Jie Sun0Ming-Hui Li1Yang Yang2Qi-Qi Dong3Hui Tao4Chao Lu5Jing-Jing Yang6Department of Clinical Pharmacology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China; School of Pharmacy, Anhui Medical University, Hefei 230032, China; Center for Scientific Research and Experiment, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, ChinaDepartment of Clinical Pharmacology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China; School of Pharmacy, Anhui Medical University, Hefei 230032, China; Center for Scientific Research and Experiment, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, ChinaDepartment of General Surgery, Suzhou Hospital, Affiliated Hospital of Medical School, Nanjing University, Suzhou 215153, ChinaDepartment of Clinical Pharmacology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China; School of Pharmacy, Anhui Medical University, Hefei 230032, China; Center for Scientific Research and Experiment, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, ChinaDepartment of Anesthesiology and Perioperative Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China; Center for Scientific Research and Experiment, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China; Corresponding author at: Department of Anesthesiology and Perioperative Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China.First Affiliated Hospital, Anhui University of Science & Technology, Huainan 232001, China; Corresponding author.Department of Clinical Pharmacology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China; Center for Scientific Research and Experiment, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China; Corresponding author at: Department of Clinical Pharmacology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China.Hepatic fibrosis is a pathologic state in which there is an excessive accumulation of the extracellular matrix (ECM) components within the liver parenchyma. It is an ongoing process that compromises the structure and functional performance of the liver tissue. Without treatment, it may progress to end-stage liver disease, including cirrhosis and hepatocellular carcinoma. The pathogenesis of hepatic fibrosis involves complex interactions between activated hepatic stellate cells (HSCs), inflammatory mediators, and angiogenic factors, which are regulated by epigenetic modifications and aberrations in signaling pathways. Recent advances highlight the emerging role of post-translational modifications (PTMs) of nucleic acid methylation protein regulators in the pathogenesis of hepatic fibrosis. These modifications affect gene expression and are critical in the development of hepatic fibrosis. This article recapitulates the existing research evidence, analyses the roles of DNA and RNA methylation, as well as their protein regulator PTMs, in hepatic fibrosis, and explains the impact of these modifications on hepatic fibrosis progression. Besides, this article considers the promising implication of these findings to launch new therapeutic strategies, providing a new perspective and direction for treating hepatic fibrosis.http://www.sciencedirect.com/science/article/pii/S1043661825002506Hepatic fibrosisDNA methylationRNA methylationRegulatory factorsPost-translational modification |
| spellingShingle | Wen-Jie Sun Ming-Hui Li Yang Yang Qi-Qi Dong Hui Tao Chao Lu Jing-Jing Yang Novel insights on post-translational modifications of nucleic acid methylation proteins in hepatic fibrosis Pharmacological Research Hepatic fibrosis DNA methylation RNA methylation Regulatory factors Post-translational modification |
| title | Novel insights on post-translational modifications of nucleic acid methylation proteins in hepatic fibrosis |
| title_full | Novel insights on post-translational modifications of nucleic acid methylation proteins in hepatic fibrosis |
| title_fullStr | Novel insights on post-translational modifications of nucleic acid methylation proteins in hepatic fibrosis |
| title_full_unstemmed | Novel insights on post-translational modifications of nucleic acid methylation proteins in hepatic fibrosis |
| title_short | Novel insights on post-translational modifications of nucleic acid methylation proteins in hepatic fibrosis |
| title_sort | novel insights on post translational modifications of nucleic acid methylation proteins in hepatic fibrosis |
| topic | Hepatic fibrosis DNA methylation RNA methylation Regulatory factors Post-translational modification |
| url | http://www.sciencedirect.com/science/article/pii/S1043661825002506 |
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