Knockdown-resistant mutations in head lice (Pediculus humanus capitis) collected from schoolchildren in Riyadh, Saudi Arabia
Abstract Head lice infestation remains one of the most common child problems. This problem is not only attributed to the ability of head lice to spread rapidly but also because of the head lice resistance that develops from incomplete or improper treatment. Pyrethroids are a group of medications tha...
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Nature Portfolio
2025-01-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-86574-y |
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| author | Imtinan H. Alghashmari Noha T. Zelai |
| author_facet | Imtinan H. Alghashmari Noha T. Zelai |
| author_sort | Imtinan H. Alghashmari |
| collection | DOAJ |
| description | Abstract Head lice infestation remains one of the most common child problems. This problem is not only attributed to the ability of head lice to spread rapidly but also because of the head lice resistance that develops from incomplete or improper treatment. Pyrethroids are a group of medications that have been widely used for the treatment of head lice. However, in recent years, several countries reported knockdown resistance (kdr). The aim of this study is to evaluate the frequency of pyrethroid-resistant mutations in Riyadh City, Saudi Arabia. To do that, Sanger sequencing was employed to find the frequency of mutated alleles in the voltage-sensitive sodium channel gene (VSSC). The result showed that the frequency of the resistant alleles in T917I was 0.83. In addition, three new mutations (L920F, V966F, and F967L) were detected in the examined samples. These findings highlight the significant prevalence of pyrethroid-resistant mutations, which may be attributed to the cultural and tourism openness that leads to the abundance of numerous job opportunities for different workforces from all around the world. |
| format | Article |
| id | doaj-art-9ce78400230c4e4f9855e73cf5d4ceba |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-9ce78400230c4e4f9855e73cf5d4ceba2025-01-19T12:24:32ZengNature PortfolioScientific Reports2045-23222025-01-011511610.1038/s41598-025-86574-yKnockdown-resistant mutations in head lice (Pediculus humanus capitis) collected from schoolchildren in Riyadh, Saudi ArabiaImtinan H. Alghashmari0Noha T. Zelai1Department of Biological Sciences, Faculty of Science, King Abdulaziz UniversityDepartment of Biological Sciences, Faculty of Science, King Abdulaziz UniversityAbstract Head lice infestation remains one of the most common child problems. This problem is not only attributed to the ability of head lice to spread rapidly but also because of the head lice resistance that develops from incomplete or improper treatment. Pyrethroids are a group of medications that have been widely used for the treatment of head lice. However, in recent years, several countries reported knockdown resistance (kdr). The aim of this study is to evaluate the frequency of pyrethroid-resistant mutations in Riyadh City, Saudi Arabia. To do that, Sanger sequencing was employed to find the frequency of mutated alleles in the voltage-sensitive sodium channel gene (VSSC). The result showed that the frequency of the resistant alleles in T917I was 0.83. In addition, three new mutations (L920F, V966F, and F967L) were detected in the examined samples. These findings highlight the significant prevalence of pyrethroid-resistant mutations, which may be attributed to the cultural and tourism openness that leads to the abundance of numerous job opportunities for different workforces from all around the world.https://doi.org/10.1038/s41598-025-86574-yHead licePyrethroidKnockdown resistance (kdr)Voltage-sensitive sodium channel geneRiyadh |
| spellingShingle | Imtinan H. Alghashmari Noha T. Zelai Knockdown-resistant mutations in head lice (Pediculus humanus capitis) collected from schoolchildren in Riyadh, Saudi Arabia Scientific Reports Head lice Pyrethroid Knockdown resistance (kdr) Voltage-sensitive sodium channel gene Riyadh |
| title | Knockdown-resistant mutations in head lice (Pediculus humanus capitis) collected from schoolchildren in Riyadh, Saudi Arabia |
| title_full | Knockdown-resistant mutations in head lice (Pediculus humanus capitis) collected from schoolchildren in Riyadh, Saudi Arabia |
| title_fullStr | Knockdown-resistant mutations in head lice (Pediculus humanus capitis) collected from schoolchildren in Riyadh, Saudi Arabia |
| title_full_unstemmed | Knockdown-resistant mutations in head lice (Pediculus humanus capitis) collected from schoolchildren in Riyadh, Saudi Arabia |
| title_short | Knockdown-resistant mutations in head lice (Pediculus humanus capitis) collected from schoolchildren in Riyadh, Saudi Arabia |
| title_sort | knockdown resistant mutations in head lice pediculus humanus capitis collected from schoolchildren in riyadh saudi arabia |
| topic | Head lice Pyrethroid Knockdown resistance (kdr) Voltage-sensitive sodium channel gene Riyadh |
| url | https://doi.org/10.1038/s41598-025-86574-y |
| work_keys_str_mv | AT imtinanhalghashmari knockdownresistantmutationsinheadlicepediculushumanuscapitiscollectedfromschoolchildreninriyadhsaudiarabia AT nohatzelai knockdownresistantmutationsinheadlicepediculushumanuscapitiscollectedfromschoolchildreninriyadhsaudiarabia |