In Vitro Bacterial Growth on Titanium Surfaces Treated with Nanosized Hydroxyapatite
Bacterial growth on implant surfaces poses a significant obstacle to the long-term success of dental and orthopedic implants. There is a need for implants that promote osseointegration while at the same time decreasing or preventing bacterial growth. In this study, the existing methods for the measu...
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MDPI AG
2025-02-01
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| Series: | Journal of Functional Biomaterials |
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| Online Access: | https://www.mdpi.com/2079-4983/16/2/66 |
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| author | Maria Holmström Sonia Esko Karin Danielsson Per Kjellin |
| author_facet | Maria Holmström Sonia Esko Karin Danielsson Per Kjellin |
| author_sort | Maria Holmström |
| collection | DOAJ |
| description | Bacterial growth on implant surfaces poses a significant obstacle to the long-term success of dental and orthopedic implants. There is a need for implants that promote osseointegration while at the same time decreasing or preventing bacterial growth. In this study, the existing methods for the measurement of bacterial biofilms were adapted so that they were suitable for measuring the bacterial growth on implant surfaces. Two different strains of bacteria, <i>Pseudomonas aeruginosa</i> and <i>Staphylococcus epidermidis,</i> were used, and the in vitro effect of bacterial growth on titanium surfaces coated with an ultrathin (20–40 nm thick) layer of nanosized hydroxyapatite (nHA) was investigated. After 2 h of biofilm growth, there was a 33% reduction in both <i>S. epidermidis</i> and <i>P. aeruginosa</i> bacteria on nHA compared to Ti. For a more mature 24 h biofilm, there was a 46% reduction in <i>S. epidermidis</i> and a 43% reduction in <i>P. aeruginosa</i> on nHA compared to Ti. This shows that coating nHA onto implants could be of benefit in reducing implant-related infections. |
| format | Article |
| id | doaj-art-9ce7751e289b4502a5089d3ae4e55fff |
| institution | DOAJ |
| issn | 2079-4983 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
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| series | Journal of Functional Biomaterials |
| spelling | doaj-art-9ce7751e289b4502a5089d3ae4e55fff2025-08-20T02:44:35ZengMDPI AGJournal of Functional Biomaterials2079-49832025-02-011626610.3390/jfb16020066In Vitro Bacterial Growth on Titanium Surfaces Treated with Nanosized HydroxyapatiteMaria Holmström0Sonia Esko1Karin Danielsson2Per Kjellin3Promimic AB, Entreprenörsstråket 10, 431 53 Mölndal, SwedenDepartment of Applied Chemistry, Chalmers University of Technology, 412 96 Göteborg, SwedenPromimic AB, Entreprenörsstråket 10, 431 53 Mölndal, SwedenPromimic AB, Entreprenörsstråket 10, 431 53 Mölndal, SwedenBacterial growth on implant surfaces poses a significant obstacle to the long-term success of dental and orthopedic implants. There is a need for implants that promote osseointegration while at the same time decreasing or preventing bacterial growth. In this study, the existing methods for the measurement of bacterial biofilms were adapted so that they were suitable for measuring the bacterial growth on implant surfaces. Two different strains of bacteria, <i>Pseudomonas aeruginosa</i> and <i>Staphylococcus epidermidis,</i> were used, and the in vitro effect of bacterial growth on titanium surfaces coated with an ultrathin (20–40 nm thick) layer of nanosized hydroxyapatite (nHA) was investigated. After 2 h of biofilm growth, there was a 33% reduction in both <i>S. epidermidis</i> and <i>P. aeruginosa</i> bacteria on nHA compared to Ti. For a more mature 24 h biofilm, there was a 46% reduction in <i>S. epidermidis</i> and a 43% reduction in <i>P. aeruginosa</i> on nHA compared to Ti. This shows that coating nHA onto implants could be of benefit in reducing implant-related infections.https://www.mdpi.com/2079-4983/16/2/66nanosized hydroxyapatiteimplantsurface coatingantibacterialbiofilm<i>S. epidermidis</i> |
| spellingShingle | Maria Holmström Sonia Esko Karin Danielsson Per Kjellin In Vitro Bacterial Growth on Titanium Surfaces Treated with Nanosized Hydroxyapatite Journal of Functional Biomaterials nanosized hydroxyapatite implant surface coating antibacterial biofilm <i>S. epidermidis</i> |
| title | In Vitro Bacterial Growth on Titanium Surfaces Treated with Nanosized Hydroxyapatite |
| title_full | In Vitro Bacterial Growth on Titanium Surfaces Treated with Nanosized Hydroxyapatite |
| title_fullStr | In Vitro Bacterial Growth on Titanium Surfaces Treated with Nanosized Hydroxyapatite |
| title_full_unstemmed | In Vitro Bacterial Growth on Titanium Surfaces Treated with Nanosized Hydroxyapatite |
| title_short | In Vitro Bacterial Growth on Titanium Surfaces Treated with Nanosized Hydroxyapatite |
| title_sort | in vitro bacterial growth on titanium surfaces treated with nanosized hydroxyapatite |
| topic | nanosized hydroxyapatite implant surface coating antibacterial biofilm <i>S. epidermidis</i> |
| url | https://www.mdpi.com/2079-4983/16/2/66 |
| work_keys_str_mv | AT mariaholmstrom invitrobacterialgrowthontitaniumsurfacestreatedwithnanosizedhydroxyapatite AT soniaesko invitrobacterialgrowthontitaniumsurfacestreatedwithnanosizedhydroxyapatite AT karindanielsson invitrobacterialgrowthontitaniumsurfacestreatedwithnanosizedhydroxyapatite AT perkjellin invitrobacterialgrowthontitaniumsurfacestreatedwithnanosizedhydroxyapatite |