Unusual Presentation of Recurrent Early Stage Endometrial Carcinoma 28 Years after Primary Surgery
Endometrial carcinoma is the most common neoplasia of female genital tract. The prognosis of early stage disease (FIGO I and FIGO II) is excellent: recurrence after surgery is less than 15%, most of which are reported within 3 years after primary treatment. Herein we report a case of late rectal rec...
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| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Surgery |
| Online Access: | http://dx.doi.org/10.1155/2015/256838 |
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| author | Alessandro Franchello Gianruggero Fronda Giacomo Deiro Alessia Fiore Davide Cassine Luca Molinaro Luigi Chiusa Sara Galati Andrea Resegotti Stefano Silvestri |
| author_facet | Alessandro Franchello Gianruggero Fronda Giacomo Deiro Alessia Fiore Davide Cassine Luca Molinaro Luigi Chiusa Sara Galati Andrea Resegotti Stefano Silvestri |
| author_sort | Alessandro Franchello |
| collection | DOAJ |
| description | Endometrial carcinoma is the most common neoplasia of female genital tract. The prognosis of early stage disease (FIGO I and FIGO II) is excellent: recurrence after surgery is less than 15%, most of which are reported within 3 years after primary treatment. Herein we report a case of late rectal recurrence from FIGO Ib endometrial adenocarcinoma. Patient had also familiar and personal history of colonic adenocarcinoma and previous findings of microsatellite instability (MSI); molecular analysis evidenced heterozygotic somatic mutation in MLH1 gene. Twenty-eight years after hysterectomy and bilateral salpingoovariectomy, a rectal wall mass was detected during routine colonoscopy. Patients underwent CT scan, pelvic MRI, and rectal EUS with FNA: histopathological and immunohistochemical analysis revealed differentiated carcinoma cells of endometrial origin. No neoadjuvant treatment was planned and low rectal anterior resection with protective colostomy was performed; histology confirmed rectal lesion as metastasis from endometrial carcinoma. Recurrence of early stage endometrial carcinoma after a long period from primary surgery is possible. It is important to keep in mind this possibility in order to set a correct diagnostic and therapeutic algorithm, including preoperative immunohistochemical staining, and to plan a prolonged follow-up program. |
| format | Article |
| id | doaj-art-9ce2738bde5e4f24a9c3f12009370671 |
| institution | Kabale University |
| issn | 2090-6900 2090-6919 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Surgery |
| spelling | doaj-art-9ce2738bde5e4f24a9c3f120093706712025-02-03T06:01:54ZengWileyCase Reports in Surgery2090-69002090-69192015-01-01201510.1155/2015/256838256838Unusual Presentation of Recurrent Early Stage Endometrial Carcinoma 28 Years after Primary SurgeryAlessandro Franchello0Gianruggero Fronda1Giacomo Deiro2Alessia Fiore3Davide Cassine4Luca Molinaro5Luigi Chiusa6Sara Galati7Andrea Resegotti8Stefano Silvestri94th General Surgery Department, Azienda Ospedaliera Universitaria Città della Salute e della Scienza, 10126 Turin, Italy4th General Surgery Department, Azienda Ospedaliera Universitaria Città della Salute e della Scienza, 10126 Turin, Italy4th General Surgery Department, Azienda Ospedaliera Universitaria Città della Salute e della Scienza, 10126 Turin, Italy4th General Surgery Department, Azienda Ospedaliera Universitaria Città della Salute e della Scienza, 10126 Turin, Italy4th General Surgery Department, Azienda Ospedaliera Universitaria Città della Salute e della Scienza, 10126 Turin, Italy2nd Phathological Anatomy Department, Azienda Ospedaliera Universitaria Città della Salute e della Scienza, 10126 Turin, Italy2nd Phathological Anatomy Department, Azienda Ospedaliera Universitaria Città della Salute e della Scienza, 10126 Turin, Italy4th General Surgery Department, Azienda Ospedaliera Universitaria Città della Salute e della Scienza, 10126 Turin, Italy4th General Surgery Department, Azienda Ospedaliera Universitaria Città della Salute e della Scienza, 10126 Turin, Italy4th General Surgery Department, Azienda Ospedaliera Universitaria Città della Salute e della Scienza, 10126 Turin, ItalyEndometrial carcinoma is the most common neoplasia of female genital tract. The prognosis of early stage disease (FIGO I and FIGO II) is excellent: recurrence after surgery is less than 15%, most of which are reported within 3 years after primary treatment. Herein we report a case of late rectal recurrence from FIGO Ib endometrial adenocarcinoma. Patient had also familiar and personal history of colonic adenocarcinoma and previous findings of microsatellite instability (MSI); molecular analysis evidenced heterozygotic somatic mutation in MLH1 gene. Twenty-eight years after hysterectomy and bilateral salpingoovariectomy, a rectal wall mass was detected during routine colonoscopy. Patients underwent CT scan, pelvic MRI, and rectal EUS with FNA: histopathological and immunohistochemical analysis revealed differentiated carcinoma cells of endometrial origin. No neoadjuvant treatment was planned and low rectal anterior resection with protective colostomy was performed; histology confirmed rectal lesion as metastasis from endometrial carcinoma. Recurrence of early stage endometrial carcinoma after a long period from primary surgery is possible. It is important to keep in mind this possibility in order to set a correct diagnostic and therapeutic algorithm, including preoperative immunohistochemical staining, and to plan a prolonged follow-up program.http://dx.doi.org/10.1155/2015/256838 |
| spellingShingle | Alessandro Franchello Gianruggero Fronda Giacomo Deiro Alessia Fiore Davide Cassine Luca Molinaro Luigi Chiusa Sara Galati Andrea Resegotti Stefano Silvestri Unusual Presentation of Recurrent Early Stage Endometrial Carcinoma 28 Years after Primary Surgery Case Reports in Surgery |
| title | Unusual Presentation of Recurrent Early Stage Endometrial Carcinoma 28 Years after Primary Surgery |
| title_full | Unusual Presentation of Recurrent Early Stage Endometrial Carcinoma 28 Years after Primary Surgery |
| title_fullStr | Unusual Presentation of Recurrent Early Stage Endometrial Carcinoma 28 Years after Primary Surgery |
| title_full_unstemmed | Unusual Presentation of Recurrent Early Stage Endometrial Carcinoma 28 Years after Primary Surgery |
| title_short | Unusual Presentation of Recurrent Early Stage Endometrial Carcinoma 28 Years after Primary Surgery |
| title_sort | unusual presentation of recurrent early stage endometrial carcinoma 28 years after primary surgery |
| url | http://dx.doi.org/10.1155/2015/256838 |
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