Calcium Alginate and Calcium Alginate-Chitosan Beads Containing Celecoxib Solubilized in a Self-Emulsifying Phase
In this work alginate and alginate-chitosan beads containing celecoxib solubilized into a self-emulsifying phase were developed in order to obtain a drug delivery system for oral administration, able to delay the drug release in acidic environment and to promote it in the intestinal compartment. The...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Scientifica |
| Online Access: | http://dx.doi.org/10.1155/2016/5062706 |
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| author | Lorena Segale Lorella Giovannelli Paolo Mannina Franco Pattarino |
| author_facet | Lorena Segale Lorella Giovannelli Paolo Mannina Franco Pattarino |
| author_sort | Lorena Segale |
| collection | DOAJ |
| description | In this work alginate and alginate-chitosan beads containing celecoxib solubilized into a self-emulsifying phase were developed in order to obtain a drug delivery system for oral administration, able to delay the drug release in acidic environment and to promote it in the intestinal compartment. The rationale of this work was linked to the desire to improve celecoxib therapeutic effectiveness reducing its gastric adverse effects and to favor its use in the prophylaxis of colon cancer and as adjuvant in the therapy of familial polyposis. The systems were prepared by ionotropic gelation using needles with different diameters (400 and 600 μm). Morphology, particle size, swelling behavior, and in vitro drug release performance of the beads in aqueous media with different pH were investigated. The experimental results demonstrated that the presence of chitosan in the formulation caused an increase of the mechanical resistance of the bead structure and, as a consequence, a limitation of the bead swelling ability and a decrease of the drug release rate at neutral pH. Alginate-chitosan beads could be a good tool to guarantee a celecoxib colon delivery. |
| format | Article |
| id | doaj-art-9cdb68f9d52f42908212571165baf0f0 |
| institution | Kabale University |
| issn | 2090-908X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Scientifica |
| spelling | doaj-art-9cdb68f9d52f42908212571165baf0f02025-02-03T06:00:39ZengWileyScientifica2090-908X2016-01-01201610.1155/2016/50627065062706Calcium Alginate and Calcium Alginate-Chitosan Beads Containing Celecoxib Solubilized in a Self-Emulsifying PhaseLorena Segale0Lorella Giovannelli1Paolo Mannina2Franco Pattarino3Dipartimento di Scienze del Farmaco, Università del Piemonte Orientale, Largo Donegani 2, 28100 Novara, ItalyDipartimento di Scienze del Farmaco, Università del Piemonte Orientale, Largo Donegani 2, 28100 Novara, ItalyDipartimento di Scienze del Farmaco, Università del Piemonte Orientale, Largo Donegani 2, 28100 Novara, ItalyDipartimento di Scienze del Farmaco, Università del Piemonte Orientale, Largo Donegani 2, 28100 Novara, ItalyIn this work alginate and alginate-chitosan beads containing celecoxib solubilized into a self-emulsifying phase were developed in order to obtain a drug delivery system for oral administration, able to delay the drug release in acidic environment and to promote it in the intestinal compartment. The rationale of this work was linked to the desire to improve celecoxib therapeutic effectiveness reducing its gastric adverse effects and to favor its use in the prophylaxis of colon cancer and as adjuvant in the therapy of familial polyposis. The systems were prepared by ionotropic gelation using needles with different diameters (400 and 600 μm). Morphology, particle size, swelling behavior, and in vitro drug release performance of the beads in aqueous media with different pH were investigated. The experimental results demonstrated that the presence of chitosan in the formulation caused an increase of the mechanical resistance of the bead structure and, as a consequence, a limitation of the bead swelling ability and a decrease of the drug release rate at neutral pH. Alginate-chitosan beads could be a good tool to guarantee a celecoxib colon delivery.http://dx.doi.org/10.1155/2016/5062706 |
| spellingShingle | Lorena Segale Lorella Giovannelli Paolo Mannina Franco Pattarino Calcium Alginate and Calcium Alginate-Chitosan Beads Containing Celecoxib Solubilized in a Self-Emulsifying Phase Scientifica |
| title | Calcium Alginate and Calcium Alginate-Chitosan Beads Containing Celecoxib Solubilized in a Self-Emulsifying Phase |
| title_full | Calcium Alginate and Calcium Alginate-Chitosan Beads Containing Celecoxib Solubilized in a Self-Emulsifying Phase |
| title_fullStr | Calcium Alginate and Calcium Alginate-Chitosan Beads Containing Celecoxib Solubilized in a Self-Emulsifying Phase |
| title_full_unstemmed | Calcium Alginate and Calcium Alginate-Chitosan Beads Containing Celecoxib Solubilized in a Self-Emulsifying Phase |
| title_short | Calcium Alginate and Calcium Alginate-Chitosan Beads Containing Celecoxib Solubilized in a Self-Emulsifying Phase |
| title_sort | calcium alginate and calcium alginate chitosan beads containing celecoxib solubilized in a self emulsifying phase |
| url | http://dx.doi.org/10.1155/2016/5062706 |
| work_keys_str_mv | AT lorenasegale calciumalginateandcalciumalginatechitosanbeadscontainingcelecoxibsolubilizedinaselfemulsifyingphase AT lorellagiovannelli calciumalginateandcalciumalginatechitosanbeadscontainingcelecoxibsolubilizedinaselfemulsifyingphase AT paolomannina calciumalginateandcalciumalginatechitosanbeadscontainingcelecoxibsolubilizedinaselfemulsifyingphase AT francopattarino calciumalginateandcalciumalginatechitosanbeadscontainingcelecoxibsolubilizedinaselfemulsifyingphase |