Brown tumor of the mandible - a possible clinical manifestation of primary hyperparathyreoidism
Introduction. One of the possible manifestations of primary hyperparathyroidism (PHPT) is the appearance of a benign bone tumor. We hereby present a case of a young woman whose first clinical manifestation of PHPT was a brown tumor of the mandible. Case report. A 27-year-old female patient was hospi...
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2023-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | https://doiserbia.nb.rs/img/doi/0042-8450/2023/0042-84502300004M.pdf |
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| author | Milankov Andrijana Mitrović Milena Ičin Tijana Bajkin Branislav Milankov Vukadin |
| author_facet | Milankov Andrijana Mitrović Milena Ičin Tijana Bajkin Branislav Milankov Vukadin |
| author_sort | Milankov Andrijana |
| collection | DOAJ |
| description | Introduction. One of the possible manifestations of primary hyperparathyroidism (PHPT) is the appearance of a benign bone tumor. We hereby present a case of a young woman whose first clinical manifestation of PHPT was a brown tumor of the mandible. Case report. A 27-year-old female patient was hospitalized at the Clinic for Endocrinology, Diabetes, and Metabolic Diseases due to problems occurring in the form of nausea, exhaustion, the feeling of suffocation, dysphagia, pain in the right ear and the right half of the cheeks, with suspected PHPT. Initial laboratory findings pointed out the high levels of parathyroid (PT) hormone (PTH) and calcium (Ca2+) ions, low levels of vitamin D, and increased parameters of bone metabolism with signs of osteopenia. Cone beam computed tomography revealed the presence of bilateral radiolucent lesions of the mandible. Scintigraphy verified a retrosternal hot focus consistent with PT adenoma. After parathyroidectomy was performed, there was a normalization of PTH values, bone metabolism parameters, and the Ca2+ values. Four months after parathyroidectomy, a significant regression of the mandibular tumefaction was confirmed, clinically and radiologically. Conclusion. Brown tumors are rare first clinical manifestations of PHPT. Owing to their histological similarities with other giant-cell lesions (GCLs), definitive diagnosis is sometimes difficult and is based on a correlation of pathohistological, radiological, and laboratory findings. Due to the spontaneous regression of bone lesions after treatment of the basic cause of PHPT, brown tumors should be considered in the differential diagnosis of any GCLs in order to avoid unnecessary surgical procedures. |
| format | Article |
| id | doaj-art-9cd6830490e544f3a8e80bf16de5f94f |
| institution | OA Journals |
| issn | 0042-8450 2406-0720 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-9cd6830490e544f3a8e80bf16de5f94f2025-08-20T02:20:19ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502406-07202023-01-01801088088410.2298/VSP220809004M0042-84502300004MBrown tumor of the mandible - a possible clinical manifestation of primary hyperparathyreoidismMilankov Andrijana0https://orcid.org/0000-0001-5815-3892Mitrović Milena1Ičin Tijana2https://orcid.org/0000-0002-3886-6518Bajkin Branislav3https://orcid.org/0000-0003-2189-6769Milankov Vukadin4https://orcid.org/0000-0001-5009-0372University Clinical Center of Vojvodina, Clinic for Endocrinology Diabetes and Metabolic Diseases, Novi Sad, Serbia + University of Novi Sad, Faculty of Medicine, Novi Sad, SerbiaUniversity Clinical Center of Vojvodina, Clinic for Endocrinology Diabetes and Metabolic Diseases, Novi Sad, Serbia + University of Novi Sad, Faculty of Medicine, Novi Sad, SerbiaUniversity Clinical Center of Vojvodina, Clinic for Endocrinology Diabetes and Metabolic Diseases, Novi Sad, Serbia + University of Novi Sad, Faculty of Medicine, Novi Sad, SerbiaUniversity of Novi Sad, Faculty of Medicine, Novi Sad, Serbia + Dentistry Clinic of Vojvodina, Novi Sad, SerbiaUniversity of Novi Sad, Faculty of Medicine, Novi Sad, Serbia + Institute for Child and Youth Healthcare of Vojvodina, Novi Sad, SerbiaIntroduction. One of the possible manifestations of primary hyperparathyroidism (PHPT) is the appearance of a benign bone tumor. We hereby present a case of a young woman whose first clinical manifestation of PHPT was a brown tumor of the mandible. Case report. A 27-year-old female patient was hospitalized at the Clinic for Endocrinology, Diabetes, and Metabolic Diseases due to problems occurring in the form of nausea, exhaustion, the feeling of suffocation, dysphagia, pain in the right ear and the right half of the cheeks, with suspected PHPT. Initial laboratory findings pointed out the high levels of parathyroid (PT) hormone (PTH) and calcium (Ca2+) ions, low levels of vitamin D, and increased parameters of bone metabolism with signs of osteopenia. Cone beam computed tomography revealed the presence of bilateral radiolucent lesions of the mandible. Scintigraphy verified a retrosternal hot focus consistent with PT adenoma. After parathyroidectomy was performed, there was a normalization of PTH values, bone metabolism parameters, and the Ca2+ values. Four months after parathyroidectomy, a significant regression of the mandibular tumefaction was confirmed, clinically and radiologically. Conclusion. Brown tumors are rare first clinical manifestations of PHPT. Owing to their histological similarities with other giant-cell lesions (GCLs), definitive diagnosis is sometimes difficult and is based on a correlation of pathohistological, radiological, and laboratory findings. Due to the spontaneous regression of bone lesions after treatment of the basic cause of PHPT, brown tumors should be considered in the differential diagnosis of any GCLs in order to avoid unnecessary surgical procedures.https://doiserbia.nb.rs/img/doi/0042-8450/2023/0042-84502300004M.pdfbone diseases, endocrinediagnosisgiant cell tumorshyperparathyroidism, primarymandible |
| spellingShingle | Milankov Andrijana Mitrović Milena Ičin Tijana Bajkin Branislav Milankov Vukadin Brown tumor of the mandible - a possible clinical manifestation of primary hyperparathyreoidism Vojnosanitetski Pregled bone diseases, endocrine diagnosis giant cell tumors hyperparathyroidism, primary mandible |
| title | Brown tumor of the mandible - a possible clinical manifestation of primary hyperparathyreoidism |
| title_full | Brown tumor of the mandible - a possible clinical manifestation of primary hyperparathyreoidism |
| title_fullStr | Brown tumor of the mandible - a possible clinical manifestation of primary hyperparathyreoidism |
| title_full_unstemmed | Brown tumor of the mandible - a possible clinical manifestation of primary hyperparathyreoidism |
| title_short | Brown tumor of the mandible - a possible clinical manifestation of primary hyperparathyreoidism |
| title_sort | brown tumor of the mandible a possible clinical manifestation of primary hyperparathyreoidism |
| topic | bone diseases, endocrine diagnosis giant cell tumors hyperparathyroidism, primary mandible |
| url | https://doiserbia.nb.rs/img/doi/0042-8450/2023/0042-84502300004M.pdf |
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