Biological Clock and Inflammatory Bowel Disease Review: From the Standpoint of the Intestinal Barrier
Inflammatory bowel disease is a group of chronic, recurrent, nonspecific inflammatory diseases of the intestine that severely affect the quality of life of patients. The pathogenesis of this disease is caused by complex and interactive neural networks composed of factors such as genetic susceptibili...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2022/2939921 |
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| _version_ | 1849399802602717184 |
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| author | Yonggang Tian Dekui Zhang |
| author_facet | Yonggang Tian Dekui Zhang |
| author_sort | Yonggang Tian |
| collection | DOAJ |
| description | Inflammatory bowel disease is a group of chronic, recurrent, nonspecific inflammatory diseases of the intestine that severely affect the quality of life of patients. The pathogenesis of this disease is caused by complex and interactive neural networks composed of factors such as genetic susceptibility, external environment, immune disorders, and intestinal barrier dysfunction. It is well known that there is a strong link between environmental stressors (also known as circadian clocks) that can influence circadian changes and inflammatory bowel disease. Among them, the biological clock is involved in the pathogenesis of inflammatory bowel disease by affecting the function of the intestinal barrier. Therefore, this review is aimed at systematically summarizing the latest research progress on the role of the circadian clock in the pathogenesis of inflammatory bowel disease by affecting intestinal barrier functions (intestinal mechanical barrier, intestinal immune barrier, intestinal microecological barrier, and intestinal chemical barrier) and the potential clinical value of clock genes in the management of inflammatory bowel disease, for the application of circadian clock therapy in the management of inflammatory bowel disease and then the benefit to the majority of patients. |
| format | Article |
| id | doaj-art-9cd53be71fe841609e871e928b89e93d |
| institution | Kabale University |
| issn | 1687-630X |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-9cd53be71fe841609e871e928b89e93d2025-08-20T03:38:15ZengWileyGastroenterology Research and Practice1687-630X2022-01-01202210.1155/2022/2939921Biological Clock and Inflammatory Bowel Disease Review: From the Standpoint of the Intestinal BarrierYonggang Tian0Dekui Zhang1Department of GastroenterologyDepartment of GastroenterologyInflammatory bowel disease is a group of chronic, recurrent, nonspecific inflammatory diseases of the intestine that severely affect the quality of life of patients. The pathogenesis of this disease is caused by complex and interactive neural networks composed of factors such as genetic susceptibility, external environment, immune disorders, and intestinal barrier dysfunction. It is well known that there is a strong link between environmental stressors (also known as circadian clocks) that can influence circadian changes and inflammatory bowel disease. Among them, the biological clock is involved in the pathogenesis of inflammatory bowel disease by affecting the function of the intestinal barrier. Therefore, this review is aimed at systematically summarizing the latest research progress on the role of the circadian clock in the pathogenesis of inflammatory bowel disease by affecting intestinal barrier functions (intestinal mechanical barrier, intestinal immune barrier, intestinal microecological barrier, and intestinal chemical barrier) and the potential clinical value of clock genes in the management of inflammatory bowel disease, for the application of circadian clock therapy in the management of inflammatory bowel disease and then the benefit to the majority of patients.http://dx.doi.org/10.1155/2022/2939921 |
| spellingShingle | Yonggang Tian Dekui Zhang Biological Clock and Inflammatory Bowel Disease Review: From the Standpoint of the Intestinal Barrier Gastroenterology Research and Practice |
| title | Biological Clock and Inflammatory Bowel Disease Review: From the Standpoint of the Intestinal Barrier |
| title_full | Biological Clock and Inflammatory Bowel Disease Review: From the Standpoint of the Intestinal Barrier |
| title_fullStr | Biological Clock and Inflammatory Bowel Disease Review: From the Standpoint of the Intestinal Barrier |
| title_full_unstemmed | Biological Clock and Inflammatory Bowel Disease Review: From the Standpoint of the Intestinal Barrier |
| title_short | Biological Clock and Inflammatory Bowel Disease Review: From the Standpoint of the Intestinal Barrier |
| title_sort | biological clock and inflammatory bowel disease review from the standpoint of the intestinal barrier |
| url | http://dx.doi.org/10.1155/2022/2939921 |
| work_keys_str_mv | AT yonggangtian biologicalclockandinflammatoryboweldiseasereviewfromthestandpointoftheintestinalbarrier AT dekuizhang biologicalclockandinflammatoryboweldiseasereviewfromthestandpointoftheintestinalbarrier |