Bone health in newly diagnosed female breast cancer patients in China: a cross-sectional study
Abstract Bone health problem is one of the important concomitant diseases of breast cancer (BC). This study aimed to investigate the bone health status of newly diagnosed female BC patients in China. A total of 636 newly diagnosed female BC patients and 268 women undergoing routine physical examinat...
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Nature Portfolio
2025-02-01
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| Online Access: | https://doi.org/10.1038/s41598-024-84698-1 |
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| author | Juan Wu Xin-yu Liang Lei Hu Ying Li Liang Ran Rui-ling She Xiu-quan Qu Bai-qing Peng Kai-nan Wu Jing Wang Ling-quan Kong |
| author_facet | Juan Wu Xin-yu Liang Lei Hu Ying Li Liang Ran Rui-ling She Xiu-quan Qu Bai-qing Peng Kai-nan Wu Jing Wang Ling-quan Kong |
| author_sort | Juan Wu |
| collection | DOAJ |
| description | Abstract Bone health problem is one of the important concomitant diseases of breast cancer (BC). This study aimed to investigate the bone health status of newly diagnosed female BC patients in China. A total of 636 newly diagnosed female BC patients and 268 women undergoing routine physical examinations (control group) were included. Bone mineral density and bone metabolism parameters were assessed. The association between BC and abnormal bone mass (ABM) was analyzed by logistic regression. We found that approximately 15.3% of BC patients presented with hypocalcemia after albumin adjustment. 25-OHVitD deficiency or insufficiency was observed in 92.3% of BC patients. ABM was identified in 63.2% of BC patients, comprising 36.4% with osteopenia and 26.8% with osteoporosis. ABM prevalence was significantly higher in BC patients under 40 years old (40.8%) compared to 8% in the age-matched control group. The severity of bone loss correlated with elevated bone turnover markers. Logistic regression analysis showed that a 5.5-fold and 3.4-fold increased risk of ABM and osteoporosis, respectively, in newly diagnosed BC patients versus the control group. All BC subtypes were associated with a markedly higher risk of ABM. Young BC patients (< 45 years) exhibited a nearly 9-fold higher risk of ABM compared to their age-matched counterparts. Vitamin D deficiency/insufficiency, osteopenia, and osteoporosis were highly prevalent among newly diagnosed female BC patients. Regardless of age and BC subtype, BC patients face a higher risk of ABM compared to those physical examination women, especially among the young. |
| format | Article |
| id | doaj-art-9cd320fcc98b4fd2a3f660015e1af52f |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-9cd320fcc98b4fd2a3f660015e1af52f2025-02-02T12:17:57ZengNature PortfolioScientific Reports2045-23222025-02-011511910.1038/s41598-024-84698-1Bone health in newly diagnosed female breast cancer patients in China: a cross-sectional studyJuan Wu0Xin-yu Liang1Lei Hu2Ying Li3Liang Ran4Rui-ling She5Xiu-quan Qu6Bai-qing Peng7Kai-nan Wu8Jing Wang9Ling-quan Kong10Department of Breast Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Breast and Thyroid Surgery, The First Affiliated Hospital of Chongqing Medical UniversityInformation Center, The First Affiliated Hospital of Chongqing Medical UniversityClinical Laboratory of the First Affiliated Hospital of Chongqing Medical UniversityHealth Management Center, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Breast and Thyroid Surgery, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Breast and Thyroid Surgery, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Breast and Thyroid Surgery, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Breast and Thyroid Surgery, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Breast Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Breast and Thyroid Surgery, The First Affiliated Hospital of Chongqing Medical UniversityAbstract Bone health problem is one of the important concomitant diseases of breast cancer (BC). This study aimed to investigate the bone health status of newly diagnosed female BC patients in China. A total of 636 newly diagnosed female BC patients and 268 women undergoing routine physical examinations (control group) were included. Bone mineral density and bone metabolism parameters were assessed. The association between BC and abnormal bone mass (ABM) was analyzed by logistic regression. We found that approximately 15.3% of BC patients presented with hypocalcemia after albumin adjustment. 25-OHVitD deficiency or insufficiency was observed in 92.3% of BC patients. ABM was identified in 63.2% of BC patients, comprising 36.4% with osteopenia and 26.8% with osteoporosis. ABM prevalence was significantly higher in BC patients under 40 years old (40.8%) compared to 8% in the age-matched control group. The severity of bone loss correlated with elevated bone turnover markers. Logistic regression analysis showed that a 5.5-fold and 3.4-fold increased risk of ABM and osteoporosis, respectively, in newly diagnosed BC patients versus the control group. All BC subtypes were associated with a markedly higher risk of ABM. Young BC patients (< 45 years) exhibited a nearly 9-fold higher risk of ABM compared to their age-matched counterparts. Vitamin D deficiency/insufficiency, osteopenia, and osteoporosis were highly prevalent among newly diagnosed female BC patients. Regardless of age and BC subtype, BC patients face a higher risk of ABM compared to those physical examination women, especially among the young.https://doi.org/10.1038/s41598-024-84698-1Breast cancerBone healthVitamin D deficiencyAbomonal bone mass |
| spellingShingle | Juan Wu Xin-yu Liang Lei Hu Ying Li Liang Ran Rui-ling She Xiu-quan Qu Bai-qing Peng Kai-nan Wu Jing Wang Ling-quan Kong Bone health in newly diagnosed female breast cancer patients in China: a cross-sectional study Scientific Reports Breast cancer Bone health Vitamin D deficiency Abomonal bone mass |
| title | Bone health in newly diagnosed female breast cancer patients in China: a cross-sectional study |
| title_full | Bone health in newly diagnosed female breast cancer patients in China: a cross-sectional study |
| title_fullStr | Bone health in newly diagnosed female breast cancer patients in China: a cross-sectional study |
| title_full_unstemmed | Bone health in newly diagnosed female breast cancer patients in China: a cross-sectional study |
| title_short | Bone health in newly diagnosed female breast cancer patients in China: a cross-sectional study |
| title_sort | bone health in newly diagnosed female breast cancer patients in china a cross sectional study |
| topic | Breast cancer Bone health Vitamin D deficiency Abomonal bone mass |
| url | https://doi.org/10.1038/s41598-024-84698-1 |
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