Nomogram based on dual-energy computed tomography to predict the response to induction chemotherapy in patients with nasopharyngeal carcinoma: a two-center study
Abstract Background Previous studies utilizing dual-energy CT (DECT) for evaluating treatment efficacy in nasopharyngeal cancinoma (NPC) are limited. This study aimed to investigate whether the parameters from DECT can predict the response to induction chemotherapy in NPC patients in two centers. Me...
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BMC
2025-01-01
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| Series: | Cancer Imaging |
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| Online Access: | https://doi.org/10.1186/s40644-025-00827-7 |
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| author | Huanhuan Ren Junhao Huang Yao Huang Bangyuan Long Mei Zhang Jing Zhang Huarong Li Tingting Huang Daihong Liu Ying Wang Jiuquan Zhang |
| author_facet | Huanhuan Ren Junhao Huang Yao Huang Bangyuan Long Mei Zhang Jing Zhang Huarong Li Tingting Huang Daihong Liu Ying Wang Jiuquan Zhang |
| author_sort | Huanhuan Ren |
| collection | DOAJ |
| description | Abstract Background Previous studies utilizing dual-energy CT (DECT) for evaluating treatment efficacy in nasopharyngeal cancinoma (NPC) are limited. This study aimed to investigate whether the parameters from DECT can predict the response to induction chemotherapy in NPC patients in two centers. Methods This two-center retrospective study included patients diagnosed with NPC who underwent contrast-enhanced DECT between March 2019 and November 2023. The clinical and DECT-derived parameters of tumor lesions were calculated to predict the response. We employed univariate and multivariate analysis to identify significant factors. Subsequently, the clinical, DECT, and clinical-DECT nomogram models were developed using independent predictors in the training cohort and validated in the test cohort. Receiver operating characteristic analysis was performed to evaluate the models’ performance. Results A total of 321 patients were included in the study, predominantly male [247 (76.9%)] with an average age of 52.04 ± 10.87 years. The training cohort (Center 1) comprised 252 patients, while the test cohort (Center 2) comprised 69 patients. Of these, 233 out of 321 patients (72.6%) were responders to induction chemotherapy. The clinical-DECT nomogram showed an AUC of 0.805 (95% CI, 0.688–0.906), outperforming both the DECT model (Extracellular volume fraction [ECVf]) (AUC, 0.706 [95% CI, 0.571–0.825]) and the clinical model (Ki67) (AUC, 0.693 [95% CI, 0.580–0.806]) in the test cohort. Conclusions Ki67 and ECVf emerged as independent predictive factors for response to induction chemotherapy in NPC patients. The proposed nomogram, incorporating ECVf, demonstrated accurate prediction of treatment response. |
| format | Article |
| id | doaj-art-9cd0b4d096f4422f80f464be917a3147 |
| institution | Kabale University |
| issn | 1470-7330 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Imaging |
| spelling | doaj-art-9cd0b4d096f4422f80f464be917a31472025-02-02T12:40:46ZengBMCCancer Imaging1470-73302025-01-0125111210.1186/s40644-025-00827-7Nomogram based on dual-energy computed tomography to predict the response to induction chemotherapy in patients with nasopharyngeal carcinoma: a two-center studyHuanhuan Ren0Junhao Huang1Yao Huang2Bangyuan Long3Mei Zhang4Jing Zhang5Huarong Li6Tingting Huang7Daihong Liu8Ying Wang9Jiuquan Zhang10Department of Radiology, Chongqing University Cancer HospitalDepartment of Radiology, Chongqing University Cancer HospitalDepartment of Radiology, Chongqing University Cancer HospitalDepartment of Radiology, Chongqing General HospitalDepartment of Radiology, Chongqing University Cancer HospitalDepartment of Radiology, Chongqing University Cancer HospitalDepartment of Radiology, Chongqing University Cancer HospitalDepartment of Radiology, Chongqing University Cancer HospitalDepartment of Radiology, Chongqing University Cancer HospitalRadiation Oncology Center, Chongqing University Cancer HospitalDepartment of Radiology, Chongqing University Cancer HospitalAbstract Background Previous studies utilizing dual-energy CT (DECT) for evaluating treatment efficacy in nasopharyngeal cancinoma (NPC) are limited. This study aimed to investigate whether the parameters from DECT can predict the response to induction chemotherapy in NPC patients in two centers. Methods This two-center retrospective study included patients diagnosed with NPC who underwent contrast-enhanced DECT between March 2019 and November 2023. The clinical and DECT-derived parameters of tumor lesions were calculated to predict the response. We employed univariate and multivariate analysis to identify significant factors. Subsequently, the clinical, DECT, and clinical-DECT nomogram models were developed using independent predictors in the training cohort and validated in the test cohort. Receiver operating characteristic analysis was performed to evaluate the models’ performance. Results A total of 321 patients were included in the study, predominantly male [247 (76.9%)] with an average age of 52.04 ± 10.87 years. The training cohort (Center 1) comprised 252 patients, while the test cohort (Center 2) comprised 69 patients. Of these, 233 out of 321 patients (72.6%) were responders to induction chemotherapy. The clinical-DECT nomogram showed an AUC of 0.805 (95% CI, 0.688–0.906), outperforming both the DECT model (Extracellular volume fraction [ECVf]) (AUC, 0.706 [95% CI, 0.571–0.825]) and the clinical model (Ki67) (AUC, 0.693 [95% CI, 0.580–0.806]) in the test cohort. Conclusions Ki67 and ECVf emerged as independent predictive factors for response to induction chemotherapy in NPC patients. The proposed nomogram, incorporating ECVf, demonstrated accurate prediction of treatment response.https://doi.org/10.1186/s40644-025-00827-7Nasopharyngeal carcinomaTreatment outcomeInduction chemotherapyTomography, X-ray computedResponse |
| spellingShingle | Huanhuan Ren Junhao Huang Yao Huang Bangyuan Long Mei Zhang Jing Zhang Huarong Li Tingting Huang Daihong Liu Ying Wang Jiuquan Zhang Nomogram based on dual-energy computed tomography to predict the response to induction chemotherapy in patients with nasopharyngeal carcinoma: a two-center study Cancer Imaging Nasopharyngeal carcinoma Treatment outcome Induction chemotherapy Tomography, X-ray computed Response |
| title | Nomogram based on dual-energy computed tomography to predict the response to induction chemotherapy in patients with nasopharyngeal carcinoma: a two-center study |
| title_full | Nomogram based on dual-energy computed tomography to predict the response to induction chemotherapy in patients with nasopharyngeal carcinoma: a two-center study |
| title_fullStr | Nomogram based on dual-energy computed tomography to predict the response to induction chemotherapy in patients with nasopharyngeal carcinoma: a two-center study |
| title_full_unstemmed | Nomogram based on dual-energy computed tomography to predict the response to induction chemotherapy in patients with nasopharyngeal carcinoma: a two-center study |
| title_short | Nomogram based on dual-energy computed tomography to predict the response to induction chemotherapy in patients with nasopharyngeal carcinoma: a two-center study |
| title_sort | nomogram based on dual energy computed tomography to predict the response to induction chemotherapy in patients with nasopharyngeal carcinoma a two center study |
| topic | Nasopharyngeal carcinoma Treatment outcome Induction chemotherapy Tomography, X-ray computed Response |
| url | https://doi.org/10.1186/s40644-025-00827-7 |
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