Detection of cervical precancerous lesions and cancer by small-scale RT-qPCR analysis of oppositely deregulated mRNAs pairs in cytological smears

Detection of cervical precancerous lesions and cancer by small-scale RT-qPCR analysis of oppositely deregulated mRNAs pairs in cytological smears

BackgroundCervical screening, aimed at detecting precancerous lesions and preventing cancer, is based on cytology and HPV testing. Both methods have limitations, the main ones being the variable diagnostic sensitivity of cytology and the moderate specificity of HPV testing. Various molecular biomark...

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Bibliographic Details
Main Authors: Anastasia A. Artyukh, Mikhail K. Ivanov, Sergei E. Titov, Victoria V. Dzyubenko, Sergey E. Krasilnikov, Anastasia O. Shumeikina, Nikita A. Afanasev, Anastasia V. Malek, Sergei A. Glushkov, Eduard F. Agletdinov
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Oncology
Subjects:
cervical cancer
squamous intraepithelial lesion
cervical screening
cytological smear
molecular biomarker
cellular mRNA
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2024.1491737/full
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