Nodal Status Assessment in Breast Cancer: Strategies of Clinical Grounds and Quality of Life Implications
Even in the era of gene-expression profiling, the nodal status still remains the primary prognostic discriminant in breast cancer patients. The exclusion of node involvement using noninvasive methods could reduce the rate of axillary surgery, thereby preventing from suffering complications. However,...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Breast Cancer |
| Online Access: | http://dx.doi.org/10.1155/2014/469803 |
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| _version_ | 1849399833570312192 |
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| author | Paolo Orsaria Dimitrios Varvaras Gianluca Vanni Giampiero Pagnani Jacopo Scaggiante Federico Frusone Alessandra Vittoria Granai Giuseppe Petrella Oreste Claudio Buonomo |
| author_facet | Paolo Orsaria Dimitrios Varvaras Gianluca Vanni Giampiero Pagnani Jacopo Scaggiante Federico Frusone Alessandra Vittoria Granai Giuseppe Petrella Oreste Claudio Buonomo |
| author_sort | Paolo Orsaria |
| collection | DOAJ |
| description | Even in the era of gene-expression profiling, the nodal status still remains the primary prognostic discriminant in breast cancer patients. The exclusion of node involvement using noninvasive methods could reduce the rate of axillary surgery, thereby preventing from suffering complications. However, lymphatic mapping with sentinel node biopsy (SNB) is one of the most interesting recent developments in surgical oncology. Optimization of procedure could be implemented by dual mapping injection site skills, resection of all hot or blue nodes through tracer combination, and improvement in atypical drainage patterns mapping. This anatomical analysis suggests safety measures in patients with high probability of node metastasis through a renewed interest in surgical management. The perspective of a guided axillary sampling (GAS) could represent a potential development of recent anatomical and functional acquisitions, offering a dynamic technique shared according to clinical and anatomical disease parameters. Furthermore, the surgical staging procedures may adopt a conservative approach through the evaluation of upper arm lymphatics, thus defining a functional model aimed at the reduction of short- and long-term adverse events. Quality results in breast cancer surgery need to generate oncological safety devoid of complications through renewed clinical experience. |
| format | Article |
| id | doaj-art-9cc8d026d423434faaed5448483a482f |
| institution | Kabale University |
| issn | 2090-3170 2090-3189 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Breast Cancer |
| spelling | doaj-art-9cc8d026d423434faaed5448483a482f2025-08-20T03:38:14ZengWileyInternational Journal of Breast Cancer2090-31702090-31892014-01-01201410.1155/2014/469803469803Nodal Status Assessment in Breast Cancer: Strategies of Clinical Grounds and Quality of Life ImplicationsPaolo Orsaria0Dimitrios Varvaras1Gianluca Vanni2Giampiero Pagnani3Jacopo Scaggiante4Federico Frusone5Alessandra Vittoria Granai6Giuseppe Petrella7Oreste Claudio Buonomo8Department of Surgery, Tor Vergata University Hospital, 00133 Rome, ItalyDepartment of Surgery, Tor Vergata University Hospital, 00133 Rome, ItalyDepartment of Surgery, Tor Vergata University Hospital, 00133 Rome, ItalyDepartment of Surgery, Tor Vergata University Hospital, 00133 Rome, ItalyDepartment of Surgery, Tor Vergata University Hospital, 00133 Rome, ItalyDepartment of Surgery, Tor Vergata University Hospital, 00133 Rome, ItalyDepartment of Surgery, Tor Vergata University Hospital, 00133 Rome, ItalyDepartment of Surgery, Tor Vergata University Hospital, 00133 Rome, ItalyDepartment of Surgery, Tor Vergata University Hospital, 00133 Rome, ItalyEven in the era of gene-expression profiling, the nodal status still remains the primary prognostic discriminant in breast cancer patients. The exclusion of node involvement using noninvasive methods could reduce the rate of axillary surgery, thereby preventing from suffering complications. However, lymphatic mapping with sentinel node biopsy (SNB) is one of the most interesting recent developments in surgical oncology. Optimization of procedure could be implemented by dual mapping injection site skills, resection of all hot or blue nodes through tracer combination, and improvement in atypical drainage patterns mapping. This anatomical analysis suggests safety measures in patients with high probability of node metastasis through a renewed interest in surgical management. The perspective of a guided axillary sampling (GAS) could represent a potential development of recent anatomical and functional acquisitions, offering a dynamic technique shared according to clinical and anatomical disease parameters. Furthermore, the surgical staging procedures may adopt a conservative approach through the evaluation of upper arm lymphatics, thus defining a functional model aimed at the reduction of short- and long-term adverse events. Quality results in breast cancer surgery need to generate oncological safety devoid of complications through renewed clinical experience.http://dx.doi.org/10.1155/2014/469803 |
| spellingShingle | Paolo Orsaria Dimitrios Varvaras Gianluca Vanni Giampiero Pagnani Jacopo Scaggiante Federico Frusone Alessandra Vittoria Granai Giuseppe Petrella Oreste Claudio Buonomo Nodal Status Assessment in Breast Cancer: Strategies of Clinical Grounds and Quality of Life Implications International Journal of Breast Cancer |
| title | Nodal Status Assessment in Breast Cancer: Strategies of Clinical Grounds and Quality of Life Implications |
| title_full | Nodal Status Assessment in Breast Cancer: Strategies of Clinical Grounds and Quality of Life Implications |
| title_fullStr | Nodal Status Assessment in Breast Cancer: Strategies of Clinical Grounds and Quality of Life Implications |
| title_full_unstemmed | Nodal Status Assessment in Breast Cancer: Strategies of Clinical Grounds and Quality of Life Implications |
| title_short | Nodal Status Assessment in Breast Cancer: Strategies of Clinical Grounds and Quality of Life Implications |
| title_sort | nodal status assessment in breast cancer strategies of clinical grounds and quality of life implications |
| url | http://dx.doi.org/10.1155/2014/469803 |
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