Analysis of the risk factors of chronic endometritis in infertile women
Abstract Objective To identify if there is a high-risk group for chronic endometritis (CE) in infertile women. Methods A retrospective single-center cohort study was conducted on 209 infertile women with CE and 843 women without. Both univariate and multivariate logistic regression were utilized to...
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| Language: | English |
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BMC
2025-07-01
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| Series: | BMC Women's Health |
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| Online Access: | https://doi.org/10.1186/s12905-025-03868-z |
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| author | Chaoyu Zhang Shan Meng Xiaojuan Tu Yang Wang Dan Meng Weixuan Zhang Yuyan Li Wei He |
| author_facet | Chaoyu Zhang Shan Meng Xiaojuan Tu Yang Wang Dan Meng Weixuan Zhang Yuyan Li Wei He |
| author_sort | Chaoyu Zhang |
| collection | DOAJ |
| description | Abstract Objective To identify if there is a high-risk group for chronic endometritis (CE) in infertile women. Methods A retrospective single-center cohort study was conducted on 209 infertile women with CE and 843 women without. Both univariate and multivariate logistic regression were utilized to examine the risk factors for CE. Results The risk of developing CE was found to be 1.8 times higher in multipara than in nullipara (OR = 1.794; 95% CI, 1.216–2.645; P = 0.003), and 1.7 times higher in patients with more than 6 years of infertility than in patients with less than 2 years of infertility (OR = 1.733; 95% CI, 1.040–2.887; P = 0.035). Patients with sequelae of pelvic inflammatory disease and endometrial hyperplasia have a 1.7-fold (OR = 1.702; 95% CI, 1.214–2.387; P = 0.002) and 2.2-fold (OR = 2.165; 95% CI, 1.376–3.406; P = 0.001) increased likelihood of developing chronic endometritis, respectively. The possibility of acquiring CE increases by 1.6 times for each increase in the number of deliveries (OR = 1.621; 95% CI, 1.200–2.189; P = 0.002) and 1.1 times for every additional year of infertility (OR = 1.077; 95% CI, 1.032–1.125; P = 0.001). Conclusion Based on univariable and multivariable regression analyses, significant risk factors for CE in infertile women include a history of pregnancy, prolonged infertility of more than 6 years, sequelae of pelvic inflammatory diseases, and endometrial hyperplasia. These findings may assist in identifying a high-risk group for CE within the infertile population. |
| format | Article |
| id | doaj-art-9cc89bed02534c90a22f8c93d417edb0 |
| institution | DOAJ |
| issn | 1472-6874 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Women's Health |
| spelling | doaj-art-9cc89bed02534c90a22f8c93d417edb02025-08-20T03:06:04ZengBMCBMC Women's Health1472-68742025-07-012511810.1186/s12905-025-03868-zAnalysis of the risk factors of chronic endometritis in infertile womenChaoyu Zhang0Shan Meng1Xiaojuan Tu2Yang Wang3Dan Meng4Weixuan Zhang5Yuyan Li6Wei He7Reproductive Medical Center, Southwest Hospital, Third Military Medical University (Army Medical University)Reproductive Medical Center, Southwest Hospital, Third Military Medical University (Army Medical University)Reproductive Medical Center, Southwest Hospital, Third Military Medical University (Army Medical University)Reproductive Medical Center, Southwest Hospital, Third Military Medical University (Army Medical University)Reproductive Medical Center, Southwest Hospital, Third Military Medical University (Army Medical University)Reproductive Medical Center, Southwest Hospital, Third Military Medical University (Army Medical University)Reproductive Medical Center, Southwest Hospital, Third Military Medical University (Army Medical University)Reproductive Medical Center, Southwest Hospital, Third Military Medical University (Army Medical University)Abstract Objective To identify if there is a high-risk group for chronic endometritis (CE) in infertile women. Methods A retrospective single-center cohort study was conducted on 209 infertile women with CE and 843 women without. Both univariate and multivariate logistic regression were utilized to examine the risk factors for CE. Results The risk of developing CE was found to be 1.8 times higher in multipara than in nullipara (OR = 1.794; 95% CI, 1.216–2.645; P = 0.003), and 1.7 times higher in patients with more than 6 years of infertility than in patients with less than 2 years of infertility (OR = 1.733; 95% CI, 1.040–2.887; P = 0.035). Patients with sequelae of pelvic inflammatory disease and endometrial hyperplasia have a 1.7-fold (OR = 1.702; 95% CI, 1.214–2.387; P = 0.002) and 2.2-fold (OR = 2.165; 95% CI, 1.376–3.406; P = 0.001) increased likelihood of developing chronic endometritis, respectively. The possibility of acquiring CE increases by 1.6 times for each increase in the number of deliveries (OR = 1.621; 95% CI, 1.200–2.189; P = 0.002) and 1.1 times for every additional year of infertility (OR = 1.077; 95% CI, 1.032–1.125; P = 0.001). Conclusion Based on univariable and multivariable regression analyses, significant risk factors for CE in infertile women include a history of pregnancy, prolonged infertility of more than 6 years, sequelae of pelvic inflammatory diseases, and endometrial hyperplasia. These findings may assist in identifying a high-risk group for CE within the infertile population.https://doi.org/10.1186/s12905-025-03868-zChronic endometritisRisk factorsDeliveryPelvic inflammatory diseaseEndometrial hyperplasia |
| spellingShingle | Chaoyu Zhang Shan Meng Xiaojuan Tu Yang Wang Dan Meng Weixuan Zhang Yuyan Li Wei He Analysis of the risk factors of chronic endometritis in infertile women BMC Women's Health Chronic endometritis Risk factors Delivery Pelvic inflammatory disease Endometrial hyperplasia |
| title | Analysis of the risk factors of chronic endometritis in infertile women |
| title_full | Analysis of the risk factors of chronic endometritis in infertile women |
| title_fullStr | Analysis of the risk factors of chronic endometritis in infertile women |
| title_full_unstemmed | Analysis of the risk factors of chronic endometritis in infertile women |
| title_short | Analysis of the risk factors of chronic endometritis in infertile women |
| title_sort | analysis of the risk factors of chronic endometritis in infertile women |
| topic | Chronic endometritis Risk factors Delivery Pelvic inflammatory disease Endometrial hyperplasia |
| url | https://doi.org/10.1186/s12905-025-03868-z |
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