Metastatic synovial sarcoma: Experience from a tertiary care center from India
Background: Synovial sarcoma represents 8% of all soft-tissue sarcoma (STS). It is a high-grade STS, and 50% of patients develop metastasis. The most common site of metastasis is the lungs, lymph nodes followed by bones. Ifosfamide-based chemotherapy is associated with improved outcome. In this stud...
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| Format: | Article |
| Language: | English |
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2019-01-01
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| Series: | Indian Journal of Medical and Paediatric Oncology |
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| Online Access: | http://www.ijmpo.org/article.asp?issn=0971-5851;year=2019;volume=40;issue=5;spage=95;epage=98;aulast=Babu |
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| author | K Govind Babu Rajesh Patidar C Lakshmaiah Kuntegowdanahalli Lokanatha Dasappa Linu Abraham Jacob Suresh Babu A H Rudresha Lokesh N Kadabur L K Rajeev Deepak Koppaka Vikas Asati |
| author_facet | K Govind Babu Rajesh Patidar C Lakshmaiah Kuntegowdanahalli Lokanatha Dasappa Linu Abraham Jacob Suresh Babu A H Rudresha Lokesh N Kadabur L K Rajeev Deepak Koppaka Vikas Asati |
| author_sort | K Govind Babu |
| collection | DOAJ |
| description | Background: Synovial sarcoma represents 8% of all soft-tissue sarcoma (STS). It is a high-grade STS, and 50% of patients develop metastasis. The most common site of metastasis is the lungs, lymph nodes followed by bones. Ifosfamide-based chemotherapy is associated with improved outcome. In this study, we report our experience of metastatic synovial sarcoma according to primary sites, metastatic pattern, and their outcome. Materials and Methods: This was a retrospective observational study carried out at our institute from January 2013 to December 2016. The aim of our study was to evaluate the pattern of metastasis, response to chemotherapy, and survival in patients with metastatic synovial sarcoma. Results: Over a period of 4 years, 43 patients with metastatic synovial sarcoma were diagnosed with median age of 30 years. Nearly 70% of patients had lung metastasis, other site of metastasis were lymph node, bone, and liver. Thirty patients received chemotherapy with a combination of ifosfamide and doxorubicin. The overall response rate was 87% with median progression-free survival of 8 months. Patients with lung only metastasis had better survival compared with nonpulmonary metastatic site (18 months vs. 12 months). The median survival was 18 months. Conclusion: Metastatic synovial sarcoma is chemoresponsive tumor with lung being the most common metastatic site. Patients with lung only metastasis had a better outcome than nonpulmonary metastasis. |
| format | Article |
| id | doaj-art-9cc6ca23d3414045bab202a2f3ad3ce5 |
| institution | Kabale University |
| issn | 0971-5851 0975-2129 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Indian Journal of Medical and Paediatric Oncology |
| spelling | doaj-art-9cc6ca23d3414045bab202a2f3ad3ce52025-08-20T03:48:41ZengThieme Medical and Scientific Publishers Pvt. Ltd.Indian Journal of Medical and Paediatric Oncology0971-58510975-21292019-01-01405959810.4103/ijmpo.ijmpo_237_17Metastatic synovial sarcoma: Experience from a tertiary care center from IndiaK Govind BabuRajesh PatidarC Lakshmaiah KuntegowdanahalliLokanatha DasappaLinu Abraham JacobSuresh BabuA H RudreshaLokesh N KadaburL K RajeevDeepak KoppakaVikas AsatiBackground: Synovial sarcoma represents 8% of all soft-tissue sarcoma (STS). It is a high-grade STS, and 50% of patients develop metastasis. The most common site of metastasis is the lungs, lymph nodes followed by bones. Ifosfamide-based chemotherapy is associated with improved outcome. In this study, we report our experience of metastatic synovial sarcoma according to primary sites, metastatic pattern, and their outcome. Materials and Methods: This was a retrospective observational study carried out at our institute from January 2013 to December 2016. The aim of our study was to evaluate the pattern of metastasis, response to chemotherapy, and survival in patients with metastatic synovial sarcoma. Results: Over a period of 4 years, 43 patients with metastatic synovial sarcoma were diagnosed with median age of 30 years. Nearly 70% of patients had lung metastasis, other site of metastasis were lymph node, bone, and liver. Thirty patients received chemotherapy with a combination of ifosfamide and doxorubicin. The overall response rate was 87% with median progression-free survival of 8 months. Patients with lung only metastasis had better survival compared with nonpulmonary metastatic site (18 months vs. 12 months). The median survival was 18 months. Conclusion: Metastatic synovial sarcoma is chemoresponsive tumor with lung being the most common metastatic site. Patients with lung only metastasis had a better outcome than nonpulmonary metastasis.http://www.ijmpo.org/article.asp?issn=0971-5851;year=2019;volume=40;issue=5;spage=95;epage=98;aulast=BabuMetastatic synovial sarcomasarcomasynovial sarcoma |
| spellingShingle | K Govind Babu Rajesh Patidar C Lakshmaiah Kuntegowdanahalli Lokanatha Dasappa Linu Abraham Jacob Suresh Babu A H Rudresha Lokesh N Kadabur L K Rajeev Deepak Koppaka Vikas Asati Metastatic synovial sarcoma: Experience from a tertiary care center from India Indian Journal of Medical and Paediatric Oncology Metastatic synovial sarcoma sarcoma synovial sarcoma |
| title | Metastatic synovial sarcoma: Experience from a tertiary care center from India |
| title_full | Metastatic synovial sarcoma: Experience from a tertiary care center from India |
| title_fullStr | Metastatic synovial sarcoma: Experience from a tertiary care center from India |
| title_full_unstemmed | Metastatic synovial sarcoma: Experience from a tertiary care center from India |
| title_short | Metastatic synovial sarcoma: Experience from a tertiary care center from India |
| title_sort | metastatic synovial sarcoma experience from a tertiary care center from india |
| topic | Metastatic synovial sarcoma sarcoma synovial sarcoma |
| url | http://www.ijmpo.org/article.asp?issn=0971-5851;year=2019;volume=40;issue=5;spage=95;epage=98;aulast=Babu |
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