Identifying PSIP1 as a critical R-loop regulator in osteosarcoma via machine-learning and multi-omics analysis

Identifying PSIP1 as a critical R-loop regulator in osteosarcoma via machine-learning and multi-omics analysis

Abstract Dysregulation of R-loops has been implicated in tumor development, progression, and the regulation of tumor immune microenvironment (TME). However, their roles in osteosarcoma (OS) remain underexplored. In this study, we firstly constructed a novel R-loop Gene Prognostic Score Model (RGPSM)...

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Bibliographic Details
Main Authors: Jiangbo Nie, Shijiang Wang, Yanxin Zhong, Feng Yang, Jiaming Liu, Zhili Liu
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Cancer Cell International
Subjects:
Osteosarcoma
R-loop
Multi-omics analysis
Machine-learning
PSIP1
Online Access:https://doi.org/10.1186/s12935-025-03775-1
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