Contribution of lipophilicity to the clinical effects of drugs
The article is devoted to a detailed analysis of the action of various drugs used in the treatment of hypertension and atherogenic dyslipidemia, depending on their ability to dissolve in fatty media (lipophilicity). The authors analyze connection between the lipophilicity level of drugs and their ph...
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| Format: | Article |
| Language: | Russian |
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«FIRMA «SILICEA» LLC
2024-04-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/5829 |
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| author | A. S. Skotnikov M. V. Melnik E. A. Zinina I. V. Sivertseva |
| author_facet | A. S. Skotnikov M. V. Melnik E. A. Zinina I. V. Sivertseva |
| author_sort | A. S. Skotnikov |
| collection | DOAJ |
| description | The article is devoted to a detailed analysis of the action of various drugs used in the treatment of hypertension and atherogenic dyslipidemia, depending on their ability to dissolve in fatty media (lipophilicity). The authors analyze connection between the lipophilicity level of drugs and their pharmacokinetics, drug-drug interactions, the manifestations of clinical effects and organ protection, as well as their ability to influence the prognosis of comorbid patients. Using angiotensin-converting enzyme inhibitors, calcium channel blockers, and statins as examples, the authors explain the practical significance of pharmacological parameters such as plasma protein binding and distribution volume, and also develop an understanding of the importance of its routine use in order to obtain clinical benefits for patients. |
| format | Article |
| id | doaj-art-9cb5e2beb63a4c2398d9f1edb41f9c29 |
| institution | DOAJ |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2024-04-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj-art-9cb5e2beb63a4c2398d9f1edb41f9c292025-08-20T03:01:27Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202024-04-0129310.15829/1560-4071-2024-58294036Contribution of lipophilicity to the clinical effects of drugsA. S. Skotnikov0M. V. Melnik1E. A. Zinina2I. V. Sivertseva3I.M. Sechenov First Moscow State Medical University; Russian State Social University; Research Center for Comorbid Pathology "Rational Medicine"I.M. Sechenov First Moscow State Medical UniversityRussian State Social UniversityRussian State Social University; Research Center for Comorbid Pathology "Rational Medicine"The article is devoted to a detailed analysis of the action of various drugs used in the treatment of hypertension and atherogenic dyslipidemia, depending on their ability to dissolve in fatty media (lipophilicity). The authors analyze connection between the lipophilicity level of drugs and their pharmacokinetics, drug-drug interactions, the manifestations of clinical effects and organ protection, as well as their ability to influence the prognosis of comorbid patients. Using angiotensin-converting enzyme inhibitors, calcium channel blockers, and statins as examples, the authors explain the practical significance of pharmacological parameters such as plasma protein binding and distribution volume, and also develop an understanding of the importance of its routine use in order to obtain clinical benefits for patients.https://russjcardiol.elpub.ru/jour/article/view/5829lipophilicityorgan protectioncomorbidityhypertensionatherogenic dyslipidemia |
| spellingShingle | A. S. Skotnikov M. V. Melnik E. A. Zinina I. V. Sivertseva Contribution of lipophilicity to the clinical effects of drugs Российский кардиологический журнал lipophilicity organ protection comorbidity hypertension atherogenic dyslipidemia |
| title | Contribution of lipophilicity to the clinical effects of drugs |
| title_full | Contribution of lipophilicity to the clinical effects of drugs |
| title_fullStr | Contribution of lipophilicity to the clinical effects of drugs |
| title_full_unstemmed | Contribution of lipophilicity to the clinical effects of drugs |
| title_short | Contribution of lipophilicity to the clinical effects of drugs |
| title_sort | contribution of lipophilicity to the clinical effects of drugs |
| topic | lipophilicity organ protection comorbidity hypertension atherogenic dyslipidemia |
| url | https://russjcardiol.elpub.ru/jour/article/view/5829 |
| work_keys_str_mv | AT asskotnikov contributionoflipophilicitytotheclinicaleffectsofdrugs AT mvmelnik contributionoflipophilicitytotheclinicaleffectsofdrugs AT eazinina contributionoflipophilicitytotheclinicaleffectsofdrugs AT ivsivertseva contributionoflipophilicitytotheclinicaleffectsofdrugs |