Practical Aspects of Clinical Manifestations, Pathogenesis and Therapy of Alcoholic Liver Disease and Non-alcoholic Fatty Liver Disease: Expert Opinion
Aim: to present the results of an expert discussion of modern aspects of the clinical manifestations, pathogenesis and treatment of alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD).Key points. ALD and NAFLD are characterized by high prevalence and have a significant impact...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2023-11-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/891 |
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| author | V. V. Tsukanov M. F. Osipenko E. V. Beloborodova M. A. Livzan I. B. Khlynov S. A. Alekseenko Yu. P. Sivolap J. L. Tonkikh A. V. Vasyutin |
| author_facet | V. V. Tsukanov M. F. Osipenko E. V. Beloborodova M. A. Livzan I. B. Khlynov S. A. Alekseenko Yu. P. Sivolap J. L. Tonkikh A. V. Vasyutin |
| author_sort | V. V. Tsukanov |
| collection | DOAJ |
| description | Aim: to present the results of an expert discussion of modern aspects of the clinical manifestations, pathogenesis and treatment of alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD).Key points. ALD and NAFLD are characterized by high prevalence and have a significant impact on public health. For the diagnosis of liver pathology, it is important to determine the stage of fibrosis and the severity of the exacerbation of the disease. In the treatment of ALD, it is recommended to achieve abstinence, proper nutrition, the appointment of B vitamins, drugs with cytoprotective activity. In severe hepatitis, corticosteroids may be prescribed. In the treatment of NAFLD, diet and lifestyle modification, weight loss, the use of insulin sensitizers, vitamin E, statins (in the presence of hyperlipidemia) and drugs with metabolic activity are effective.Currently, a point of view is being actively expressed about the synergism of the action of alcohol and the metabolic syndrome on the development of fibrosis, cirrhosis, and hepatocellular carcinoma. The current international consensus recommends a change in the nomenclature of NAFLD and ALD and proposes the terms “metabolically associated steatotic liver disease” and “metabolically associated alcoholic liver disease”.Conclusion. The closeness of the clinical manifestations and pathogenesis of NAFLD and ALD justifies attention to drugs with metabolic activity, which are recommended by the Russian Gastroenterological Association and Russian Scientific Liver Society for the treatment of these diseases. The experts support the suggestion to quantify alcohol consumption in patients with NAFLD in order to change the management of patients, if necessary. |
| format | Article |
| id | doaj-art-9cb1ae32faaf415ea04d59513cd8757f |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2023-11-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-9cb1ae32faaf415ea04d59513cd8757f2025-02-10T16:14:38ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732023-11-0133471310.22416/1382-4376-2023-33-4-7-13562Practical Aspects of Clinical Manifestations, Pathogenesis and Therapy of Alcoholic Liver Disease and Non-alcoholic Fatty Liver Disease: Expert OpinionV. V. Tsukanov0M. F. Osipenko1E. V. Beloborodova2M. A. Livzan3I. B. Khlynov4S. A. Alekseenko5Yu. P. Sivolap6J. L. Tonkikh7A. V. Vasyutin8Federal Research Centre “Krasnoyarsk Science Centre” of the Siberian Branch of Russian Academy of Science”, Scientific Research Institute of Medical Problems of the NorthNovosibirsk State Medical UniversitySiberian State Medical UniversityOmsk State Medical UniversityUral State Medical UniversityFar-Eastern State Medical UniversityRUDN UniversityFederal Research Centre “Krasnoyarsk Science Centre” of the Siberian Branch of Russian Academy of Science”, Scientific Research Institute of Medical Problems of the NorthFederal Research Centre “Krasnoyarsk Science Centre” of the Siberian Branch of Russian Academy of Science”, Scientific Research Institute of Medical Problems of the NorthAim: to present the results of an expert discussion of modern aspects of the clinical manifestations, pathogenesis and treatment of alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD).Key points. ALD and NAFLD are characterized by high prevalence and have a significant impact on public health. For the diagnosis of liver pathology, it is important to determine the stage of fibrosis and the severity of the exacerbation of the disease. In the treatment of ALD, it is recommended to achieve abstinence, proper nutrition, the appointment of B vitamins, drugs with cytoprotective activity. In severe hepatitis, corticosteroids may be prescribed. In the treatment of NAFLD, diet and lifestyle modification, weight loss, the use of insulin sensitizers, vitamin E, statins (in the presence of hyperlipidemia) and drugs with metabolic activity are effective.Currently, a point of view is being actively expressed about the synergism of the action of alcohol and the metabolic syndrome on the development of fibrosis, cirrhosis, and hepatocellular carcinoma. The current international consensus recommends a change in the nomenclature of NAFLD and ALD and proposes the terms “metabolically associated steatotic liver disease” and “metabolically associated alcoholic liver disease”.Conclusion. The closeness of the clinical manifestations and pathogenesis of NAFLD and ALD justifies attention to drugs with metabolic activity, which are recommended by the Russian Gastroenterological Association and Russian Scientific Liver Society for the treatment of these diseases. The experts support the suggestion to quantify alcohol consumption in patients with NAFLD in order to change the management of patients, if necessary.https://www.gastro-j.ru/jour/article/view/891alcoholic liver disease (ald)non-alcoholic fatty liver disease (nafld)alcohol, clinical picturepathogenesistreatment |
| spellingShingle | V. V. Tsukanov M. F. Osipenko E. V. Beloborodova M. A. Livzan I. B. Khlynov S. A. Alekseenko Yu. P. Sivolap J. L. Tonkikh A. V. Vasyutin Practical Aspects of Clinical Manifestations, Pathogenesis and Therapy of Alcoholic Liver Disease and Non-alcoholic Fatty Liver Disease: Expert Opinion Российский журнал гастроэнтерологии, гепатологии, колопроктологии alcoholic liver disease (ald) non-alcoholic fatty liver disease (nafld) alcohol, clinical picture pathogenesis treatment |
| title | Practical Aspects of Clinical Manifestations, Pathogenesis and Therapy of Alcoholic Liver Disease and Non-alcoholic Fatty Liver Disease: Expert Opinion |
| title_full | Practical Aspects of Clinical Manifestations, Pathogenesis and Therapy of Alcoholic Liver Disease and Non-alcoholic Fatty Liver Disease: Expert Opinion |
| title_fullStr | Practical Aspects of Clinical Manifestations, Pathogenesis and Therapy of Alcoholic Liver Disease and Non-alcoholic Fatty Liver Disease: Expert Opinion |
| title_full_unstemmed | Practical Aspects of Clinical Manifestations, Pathogenesis and Therapy of Alcoholic Liver Disease and Non-alcoholic Fatty Liver Disease: Expert Opinion |
| title_short | Practical Aspects of Clinical Manifestations, Pathogenesis and Therapy of Alcoholic Liver Disease and Non-alcoholic Fatty Liver Disease: Expert Opinion |
| title_sort | practical aspects of clinical manifestations pathogenesis and therapy of alcoholic liver disease and non alcoholic fatty liver disease expert opinion |
| topic | alcoholic liver disease (ald) non-alcoholic fatty liver disease (nafld) alcohol, clinical picture pathogenesis treatment |
| url | https://www.gastro-j.ru/jour/article/view/891 |
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