Exploring Antibacterial Properties of Marine Sponge-Derived Natural Compounds: A Systematic Review

The rise in multidrug-resistant (MDR) bacteria has prompted extensive research into antibacterial compounds, as these resistant strains compromise current treatments. This resistance leads to prolonged hospitalization, increased mortality rates, and higher healthcare costs. To address this challenge...

Full description

Saved in:
Bibliographic Details
Main Authors: Cintia Cristina Santi Martignago, Camila de Souza Barbosa, Homero Garcia Motta, Beatriz Soares-Silva, Erica Paloma Maso Lopes Peres, Lais Caroline Souza e Silva, Mirian Bonifácio, Karolyne dos Santos Jorge Sousa, Amanda Sardeli Alqualo, Júlia Parisi, Olivier Jordan, Ana Claudia Muniz Renno, Anna Caroline Campos Aguiar, Viorica Patrulea
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Marine Drugs
Subjects:
Online Access:https://www.mdpi.com/1660-3397/23/1/43
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1832588076910641152
author Cintia Cristina Santi Martignago
Camila de Souza Barbosa
Homero Garcia Motta
Beatriz Soares-Silva
Erica Paloma Maso Lopes Peres
Lais Caroline Souza e Silva
Mirian Bonifácio
Karolyne dos Santos Jorge Sousa
Amanda Sardeli Alqualo
Júlia Parisi
Olivier Jordan
Ana Claudia Muniz Renno
Anna Caroline Campos Aguiar
Viorica Patrulea
author_facet Cintia Cristina Santi Martignago
Camila de Souza Barbosa
Homero Garcia Motta
Beatriz Soares-Silva
Erica Paloma Maso Lopes Peres
Lais Caroline Souza e Silva
Mirian Bonifácio
Karolyne dos Santos Jorge Sousa
Amanda Sardeli Alqualo
Júlia Parisi
Olivier Jordan
Ana Claudia Muniz Renno
Anna Caroline Campos Aguiar
Viorica Patrulea
author_sort Cintia Cristina Santi Martignago
collection DOAJ
description The rise in multidrug-resistant (MDR) bacteria has prompted extensive research into antibacterial compounds, as these resistant strains compromise current treatments. This resistance leads to prolonged hospitalization, increased mortality rates, and higher healthcare costs. To address this challenge, the pharmaceutical industry is increasingly exploring natural products, particularly those of marine origin, as promising candidates for antimicrobial drugs. Marine sponges, in particular, are of interest because of their production of secondary metabolites (SM), which serve as chemical defenses against predators and pathogens. These metabolites exhibit a wide range of therapeutic properties, including antibacterial activity. This systematic review examines recent advancements in identifying new sponge-derived compounds with antimicrobial activity, specifically targeting <i>Pseudomonas aeruginosa</i>, a prevalent Gram-negative pathogen with the highest incidence rates in clinical settings. The selection criteria focused on antimicrobial compounds with reported Minimum Inhibitory Concentration (MIC) values. The identified SM include alkaloids, sesterterpenoids, nitrogenous diterpene, and bromotyrosine-derived derivatives. The structural features of the active compounds selected in this review may provide a foundational framework for developing new, highly bioactive antimicrobial agents.
format Article
id doaj-art-9cad604f5b7941b9a750ddb7ea60b4fb
institution Kabale University
issn 1660-3397
language English
publishDate 2025-01-01
publisher MDPI AG
record_format Article
series Marine Drugs
spelling doaj-art-9cad604f5b7941b9a750ddb7ea60b4fb2025-01-24T13:39:36ZengMDPI AGMarine Drugs1660-33972025-01-012314310.3390/md23010043Exploring Antibacterial Properties of Marine Sponge-Derived Natural Compounds: A Systematic ReviewCintia Cristina Santi Martignago0Camila de Souza Barbosa1Homero Garcia Motta2Beatriz Soares-Silva3Erica Paloma Maso Lopes Peres4Lais Caroline Souza e Silva5Mirian Bonifácio6Karolyne dos Santos Jorge Sousa7Amanda Sardeli Alqualo8Júlia Parisi9Olivier Jordan10Ana Claudia Muniz Renno11Anna Caroline Campos Aguiar12Viorica Patrulea13Department of Bioscience, Federal University of São Paulo, Santos 11015-020, SP, BrazilDepartment of Microbiology Immunobiology and Parasitology, Paulist School of Medicine, Federal University of São Paulo, São Paulo 04023-062, SP, BrazilDepartment of Bioscience, Federal University of São Paulo, Santos 11015-020, SP, BrazilDepartment of Bioscience, Federal University of São Paulo, Santos 11015-020, SP, BrazilDepartment of Bioscience, Federal University of São Paulo, Santos 11015-020, SP, BrazilDepartment of Bioscience, Federal University of São Paulo, Santos 11015-020, SP, BrazilDepartment of Bioscience, Federal University of São Paulo, Santos 11015-020, SP, BrazilDepartment of Bioscience, Federal University of São Paulo, Santos 11015-020, SP, BrazilDepartment of Bioscience, Federal University of São Paulo, Santos 11015-020, SP, BrazilDepartment of Physiotherapy, Metropolitan University of Santos (UNIMES), Santos 11045-001, SP, BrazilInstitute of Pharmaceutical Sciences of Western Switzerland (ISPSO), University of Geneva, 1206 Geneva, SwitzerlandDepartment of Bioscience, Federal University of São Paulo, Santos 11015-020, SP, BrazilDepartment of Microbiology Immunobiology and Parasitology, Paulist School of Medicine, Federal University of São Paulo, São Paulo 04023-062, SP, BrazilInstitute of Pharmaceutical Sciences of Western Switzerland (ISPSO), University of Geneva, 1206 Geneva, SwitzerlandThe rise in multidrug-resistant (MDR) bacteria has prompted extensive research into antibacterial compounds, as these resistant strains compromise current treatments. This resistance leads to prolonged hospitalization, increased mortality rates, and higher healthcare costs. To address this challenge, the pharmaceutical industry is increasingly exploring natural products, particularly those of marine origin, as promising candidates for antimicrobial drugs. Marine sponges, in particular, are of interest because of their production of secondary metabolites (SM), which serve as chemical defenses against predators and pathogens. These metabolites exhibit a wide range of therapeutic properties, including antibacterial activity. This systematic review examines recent advancements in identifying new sponge-derived compounds with antimicrobial activity, specifically targeting <i>Pseudomonas aeruginosa</i>, a prevalent Gram-negative pathogen with the highest incidence rates in clinical settings. The selection criteria focused on antimicrobial compounds with reported Minimum Inhibitory Concentration (MIC) values. The identified SM include alkaloids, sesterterpenoids, nitrogenous diterpene, and bromotyrosine-derived derivatives. The structural features of the active compounds selected in this review may provide a foundational framework for developing new, highly bioactive antimicrobial agents.https://www.mdpi.com/1660-3397/23/1/43antibacterialmarine spongemultidrug-resistantnatural product<i>P. aeruginosa</i>
spellingShingle Cintia Cristina Santi Martignago
Camila de Souza Barbosa
Homero Garcia Motta
Beatriz Soares-Silva
Erica Paloma Maso Lopes Peres
Lais Caroline Souza e Silva
Mirian Bonifácio
Karolyne dos Santos Jorge Sousa
Amanda Sardeli Alqualo
Júlia Parisi
Olivier Jordan
Ana Claudia Muniz Renno
Anna Caroline Campos Aguiar
Viorica Patrulea
Exploring Antibacterial Properties of Marine Sponge-Derived Natural Compounds: A Systematic Review
Marine Drugs
antibacterial
marine sponge
multidrug-resistant
natural product
<i>P. aeruginosa</i>
title Exploring Antibacterial Properties of Marine Sponge-Derived Natural Compounds: A Systematic Review
title_full Exploring Antibacterial Properties of Marine Sponge-Derived Natural Compounds: A Systematic Review
title_fullStr Exploring Antibacterial Properties of Marine Sponge-Derived Natural Compounds: A Systematic Review
title_full_unstemmed Exploring Antibacterial Properties of Marine Sponge-Derived Natural Compounds: A Systematic Review
title_short Exploring Antibacterial Properties of Marine Sponge-Derived Natural Compounds: A Systematic Review
title_sort exploring antibacterial properties of marine sponge derived natural compounds a systematic review
topic antibacterial
marine sponge
multidrug-resistant
natural product
<i>P. aeruginosa</i>
url https://www.mdpi.com/1660-3397/23/1/43
work_keys_str_mv AT cintiacristinasantimartignago exploringantibacterialpropertiesofmarinespongederivednaturalcompoundsasystematicreview
AT camiladesouzabarbosa exploringantibacterialpropertiesofmarinespongederivednaturalcompoundsasystematicreview
AT homerogarciamotta exploringantibacterialpropertiesofmarinespongederivednaturalcompoundsasystematicreview
AT beatrizsoaressilva exploringantibacterialpropertiesofmarinespongederivednaturalcompoundsasystematicreview
AT ericapalomamasolopesperes exploringantibacterialpropertiesofmarinespongederivednaturalcompoundsasystematicreview
AT laiscarolinesouzaesilva exploringantibacterialpropertiesofmarinespongederivednaturalcompoundsasystematicreview
AT mirianbonifacio exploringantibacterialpropertiesofmarinespongederivednaturalcompoundsasystematicreview
AT karolynedossantosjorgesousa exploringantibacterialpropertiesofmarinespongederivednaturalcompoundsasystematicreview
AT amandasardelialqualo exploringantibacterialpropertiesofmarinespongederivednaturalcompoundsasystematicreview
AT juliaparisi exploringantibacterialpropertiesofmarinespongederivednaturalcompoundsasystematicreview
AT olivierjordan exploringantibacterialpropertiesofmarinespongederivednaturalcompoundsasystematicreview
AT anaclaudiamunizrenno exploringantibacterialpropertiesofmarinespongederivednaturalcompoundsasystematicreview
AT annacarolinecamposaguiar exploringantibacterialpropertiesofmarinespongederivednaturalcompoundsasystematicreview
AT vioricapatrulea exploringantibacterialpropertiesofmarinespongederivednaturalcompoundsasystematicreview