Exploring Antibacterial Properties of Marine Sponge-Derived Natural Compounds: A Systematic Review
The rise in multidrug-resistant (MDR) bacteria has prompted extensive research into antibacterial compounds, as these resistant strains compromise current treatments. This resistance leads to prolonged hospitalization, increased mortality rates, and higher healthcare costs. To address this challenge...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-01-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/23/1/43 |
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| author | Cintia Cristina Santi Martignago Camila de Souza Barbosa Homero Garcia Motta Beatriz Soares-Silva Erica Paloma Maso Lopes Peres Lais Caroline Souza e Silva Mirian Bonifácio Karolyne dos Santos Jorge Sousa Amanda Sardeli Alqualo Júlia Parisi Olivier Jordan Ana Claudia Muniz Renno Anna Caroline Campos Aguiar Viorica Patrulea |
| author_facet | Cintia Cristina Santi Martignago Camila de Souza Barbosa Homero Garcia Motta Beatriz Soares-Silva Erica Paloma Maso Lopes Peres Lais Caroline Souza e Silva Mirian Bonifácio Karolyne dos Santos Jorge Sousa Amanda Sardeli Alqualo Júlia Parisi Olivier Jordan Ana Claudia Muniz Renno Anna Caroline Campos Aguiar Viorica Patrulea |
| author_sort | Cintia Cristina Santi Martignago |
| collection | DOAJ |
| description | The rise in multidrug-resistant (MDR) bacteria has prompted extensive research into antibacterial compounds, as these resistant strains compromise current treatments. This resistance leads to prolonged hospitalization, increased mortality rates, and higher healthcare costs. To address this challenge, the pharmaceutical industry is increasingly exploring natural products, particularly those of marine origin, as promising candidates for antimicrobial drugs. Marine sponges, in particular, are of interest because of their production of secondary metabolites (SM), which serve as chemical defenses against predators and pathogens. These metabolites exhibit a wide range of therapeutic properties, including antibacterial activity. This systematic review examines recent advancements in identifying new sponge-derived compounds with antimicrobial activity, specifically targeting <i>Pseudomonas aeruginosa</i>, a prevalent Gram-negative pathogen with the highest incidence rates in clinical settings. The selection criteria focused on antimicrobial compounds with reported Minimum Inhibitory Concentration (MIC) values. The identified SM include alkaloids, sesterterpenoids, nitrogenous diterpene, and bromotyrosine-derived derivatives. The structural features of the active compounds selected in this review may provide a foundational framework for developing new, highly bioactive antimicrobial agents. |
| format | Article |
| id | doaj-art-9cad604f5b7941b9a750ddb7ea60b4fb |
| institution | Kabale University |
| issn | 1660-3397 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj-art-9cad604f5b7941b9a750ddb7ea60b4fb2025-01-24T13:39:36ZengMDPI AGMarine Drugs1660-33972025-01-012314310.3390/md23010043Exploring Antibacterial Properties of Marine Sponge-Derived Natural Compounds: A Systematic ReviewCintia Cristina Santi Martignago0Camila de Souza Barbosa1Homero Garcia Motta2Beatriz Soares-Silva3Erica Paloma Maso Lopes Peres4Lais Caroline Souza e Silva5Mirian Bonifácio6Karolyne dos Santos Jorge Sousa7Amanda Sardeli Alqualo8Júlia Parisi9Olivier Jordan10Ana Claudia Muniz Renno11Anna Caroline Campos Aguiar12Viorica Patrulea13Department of Bioscience, Federal University of São Paulo, Santos 11015-020, SP, BrazilDepartment of Microbiology Immunobiology and Parasitology, Paulist School of Medicine, Federal University of São Paulo, São Paulo 04023-062, SP, BrazilDepartment of Bioscience, Federal University of São Paulo, Santos 11015-020, SP, BrazilDepartment of Bioscience, Federal University of São Paulo, Santos 11015-020, SP, BrazilDepartment of Bioscience, Federal University of São Paulo, Santos 11015-020, SP, BrazilDepartment of Bioscience, Federal University of São Paulo, Santos 11015-020, SP, BrazilDepartment of Bioscience, Federal University of São Paulo, Santos 11015-020, SP, BrazilDepartment of Bioscience, Federal University of São Paulo, Santos 11015-020, SP, BrazilDepartment of Bioscience, Federal University of São Paulo, Santos 11015-020, SP, BrazilDepartment of Physiotherapy, Metropolitan University of Santos (UNIMES), Santos 11045-001, SP, BrazilInstitute of Pharmaceutical Sciences of Western Switzerland (ISPSO), University of Geneva, 1206 Geneva, SwitzerlandDepartment of Bioscience, Federal University of São Paulo, Santos 11015-020, SP, BrazilDepartment of Microbiology Immunobiology and Parasitology, Paulist School of Medicine, Federal University of São Paulo, São Paulo 04023-062, SP, BrazilInstitute of Pharmaceutical Sciences of Western Switzerland (ISPSO), University of Geneva, 1206 Geneva, SwitzerlandThe rise in multidrug-resistant (MDR) bacteria has prompted extensive research into antibacterial compounds, as these resistant strains compromise current treatments. This resistance leads to prolonged hospitalization, increased mortality rates, and higher healthcare costs. To address this challenge, the pharmaceutical industry is increasingly exploring natural products, particularly those of marine origin, as promising candidates for antimicrobial drugs. Marine sponges, in particular, are of interest because of their production of secondary metabolites (SM), which serve as chemical defenses against predators and pathogens. These metabolites exhibit a wide range of therapeutic properties, including antibacterial activity. This systematic review examines recent advancements in identifying new sponge-derived compounds with antimicrobial activity, specifically targeting <i>Pseudomonas aeruginosa</i>, a prevalent Gram-negative pathogen with the highest incidence rates in clinical settings. The selection criteria focused on antimicrobial compounds with reported Minimum Inhibitory Concentration (MIC) values. The identified SM include alkaloids, sesterterpenoids, nitrogenous diterpene, and bromotyrosine-derived derivatives. The structural features of the active compounds selected in this review may provide a foundational framework for developing new, highly bioactive antimicrobial agents.https://www.mdpi.com/1660-3397/23/1/43antibacterialmarine spongemultidrug-resistantnatural product<i>P. aeruginosa</i> |
| spellingShingle | Cintia Cristina Santi Martignago Camila de Souza Barbosa Homero Garcia Motta Beatriz Soares-Silva Erica Paloma Maso Lopes Peres Lais Caroline Souza e Silva Mirian Bonifácio Karolyne dos Santos Jorge Sousa Amanda Sardeli Alqualo Júlia Parisi Olivier Jordan Ana Claudia Muniz Renno Anna Caroline Campos Aguiar Viorica Patrulea Exploring Antibacterial Properties of Marine Sponge-Derived Natural Compounds: A Systematic Review Marine Drugs antibacterial marine sponge multidrug-resistant natural product <i>P. aeruginosa</i> |
| title | Exploring Antibacterial Properties of Marine Sponge-Derived Natural Compounds: A Systematic Review |
| title_full | Exploring Antibacterial Properties of Marine Sponge-Derived Natural Compounds: A Systematic Review |
| title_fullStr | Exploring Antibacterial Properties of Marine Sponge-Derived Natural Compounds: A Systematic Review |
| title_full_unstemmed | Exploring Antibacterial Properties of Marine Sponge-Derived Natural Compounds: A Systematic Review |
| title_short | Exploring Antibacterial Properties of Marine Sponge-Derived Natural Compounds: A Systematic Review |
| title_sort | exploring antibacterial properties of marine sponge derived natural compounds a systematic review |
| topic | antibacterial marine sponge multidrug-resistant natural product <i>P. aeruginosa</i> |
| url | https://www.mdpi.com/1660-3397/23/1/43 |
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