Neuropsychiatric symptoms and specific cognitive domains in mild cognitive impairment
ABSTRACT. Neuropsychiatric symptoms (NPS) such as depression, anxiety, and apathy are present in mild cognitive impairment (MCI) and are risk factors for cognitive decline. However, the relationship between NPS and specific cognitive domains is less clear. Objective: This study aimed to assess whet...
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| Language: | English |
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Associação Neurologia Cognitiva e do Comportamento
2025-01-01
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| Series: | Dementia & Neuropsychologia |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642024000100322&lng=en&tlng=en |
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| author | Lucas Luchesi Barnes Lucas Francisco Botequio Mella Francisca Daniele Ferreira Lopes Amilton dos Santos Junior Paulo Dalgalarrondo |
| author_facet | Lucas Luchesi Barnes Lucas Francisco Botequio Mella Francisca Daniele Ferreira Lopes Amilton dos Santos Junior Paulo Dalgalarrondo |
| author_sort | Lucas Luchesi Barnes |
| collection | DOAJ |
| description | ABSTRACT. Neuropsychiatric symptoms (NPS) such as depression, anxiety, and apathy are present in mild cognitive impairment (MCI) and are risk factors for cognitive decline. However, the relationship between NPS and specific cognitive domains is less clear. Objective: This study aimed to assess whether there is a correlation between NPS and specific cognitive domains. Methods: A cross-sectional study which included 174 participants with MCI, aged 55 years or older. Differences in sociodemographic profile, neuroimaging, and neuropsychological tests between MCI participants with and without NPS were measured. Results: Participants with NPS had lower education and worse performance in attention tests and executive functions. Psychotic symptoms were correlated with deficits in visuospatial functions; irritability and agitation with inattention and deficit of inhibitory control; and depression with inattention. Conclusion: Correlations were found between some NPS with specific cognitive domains, especially psychotic symptoms, but also agitation, irritability, apathy, and depression. |
| format | Article |
| id | doaj-art-9ca26832880049038560cc1ce94877d9 |
| institution | Kabale University |
| issn | 1980-5764 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Associação Neurologia Cognitiva e do Comportamento |
| record_format | Article |
| series | Dementia & Neuropsychologia |
| spelling | doaj-art-9ca26832880049038560cc1ce94877d92025-01-21T07:38:21ZengAssociação Neurologia Cognitiva e do ComportamentoDementia & Neuropsychologia1980-57642025-01-011810.1590/1980-5764-dn-2024-0187Neuropsychiatric symptoms and specific cognitive domains in mild cognitive impairmentLucas Luchesi Barneshttps://orcid.org/0000-0003-1037-6047Lucas Francisco Botequio Mellahttps://orcid.org/0000-0002-4298-9553Francisca Daniele Ferreira Lopeshttps://orcid.org/0000-0002-2057-1957Amilton dos Santos Juniorhttps://orcid.org/0000-0002-4328-4619Paulo Dalgalarrondohttps://orcid.org/0000-0001-9870-6391ABSTRACT. Neuropsychiatric symptoms (NPS) such as depression, anxiety, and apathy are present in mild cognitive impairment (MCI) and are risk factors for cognitive decline. However, the relationship between NPS and specific cognitive domains is less clear. Objective: This study aimed to assess whether there is a correlation between NPS and specific cognitive domains. Methods: A cross-sectional study which included 174 participants with MCI, aged 55 years or older. Differences in sociodemographic profile, neuroimaging, and neuropsychological tests between MCI participants with and without NPS were measured. Results: Participants with NPS had lower education and worse performance in attention tests and executive functions. Psychotic symptoms were correlated with deficits in visuospatial functions; irritability and agitation with inattention and deficit of inhibitory control; and depression with inattention. Conclusion: Correlations were found between some NPS with specific cognitive domains, especially psychotic symptoms, but also agitation, irritability, apathy, and depression.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642024000100322&lng=en&tlng=enCognitive DysfunctionNeurobehavioral ManifestationsNeuropsychological Tests |
| spellingShingle | Lucas Luchesi Barnes Lucas Francisco Botequio Mella Francisca Daniele Ferreira Lopes Amilton dos Santos Junior Paulo Dalgalarrondo Neuropsychiatric symptoms and specific cognitive domains in mild cognitive impairment Dementia & Neuropsychologia Cognitive Dysfunction Neurobehavioral Manifestations Neuropsychological Tests |
| title | Neuropsychiatric symptoms and specific cognitive domains in mild cognitive impairment |
| title_full | Neuropsychiatric symptoms and specific cognitive domains in mild cognitive impairment |
| title_fullStr | Neuropsychiatric symptoms and specific cognitive domains in mild cognitive impairment |
| title_full_unstemmed | Neuropsychiatric symptoms and specific cognitive domains in mild cognitive impairment |
| title_short | Neuropsychiatric symptoms and specific cognitive domains in mild cognitive impairment |
| title_sort | neuropsychiatric symptoms and specific cognitive domains in mild cognitive impairment |
| topic | Cognitive Dysfunction Neurobehavioral Manifestations Neuropsychological Tests |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642024000100322&lng=en&tlng=en |
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