Elucidating Ionization Behavior: Potentiometric Titration for Precise Determination of pKa Values in Medicinal Chemistry
The determination of pKa values holds paramount importance in the field of medicinal chemistry, serving as a critical parameter for understanding the ionization behavior of pharmaceutical compounds. This study employs potentiometric titration as a precise method to elucidate the pKa values of divers...
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| Format: | Article |
| Language: | English |
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Atatürk University
2024-04-01
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| Series: | Pharmata |
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| Online Access: | https://dergipark.org.tr/en/download/article-file/3684876 |
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| _version_ | 1850253908798078976 |
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| author | Safiye Nihal Aydoğdu Durişehvar Ünal |
| author_facet | Safiye Nihal Aydoğdu Durişehvar Ünal |
| author_sort | Safiye Nihal Aydoğdu |
| collection | DOAJ |
| description | The determination of pKa values holds paramount importance in the field of medicinal chemistry, serving as a critical parameter for understanding the ionization behavior of pharmaceutical compounds. This study employs potentiometric titration as a precise method to elucidate the pKa values of diverse molecules. The experimental methodology involved a carefully controlled titration setup, utilizing a pH meter to monitor the titration curve and identify inflection points corresponding to the dissociation of acidic or basic functional groups. |
| format | Article |
| id | doaj-art-9c9f9b2799d14010b3dd5c5a1ea8fef1 |
| institution | OA Journals |
| issn | 2980-1966 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Atatürk University |
| record_format | Article |
| series | Pharmata |
| spelling | doaj-art-9c9f9b2799d14010b3dd5c5a1ea8fef12025-08-20T01:57:15ZengAtatürk UniversityPharmata2980-19662024-04-0142465055Elucidating Ionization Behavior: Potentiometric Titration for Precise Determination of pKa Values in Medicinal ChemistrySafiye Nihal Aydoğduhttps://orcid.org/0009-0009-3102-878XDurişehvar Ünal0https://orcid.org/0000-0003-0754-1240İSTANBUL ÜNİVERSİTESİ, ECZACILIK FAKÜLTESİ, TEMEL ECZACILIK BİLİMLERİ BÖLÜMÜ, ANALİTİK KİMYA ANABİLİM DALI, GENEL KİMYA BİLİM DALIThe determination of pKa values holds paramount importance in the field of medicinal chemistry, serving as a critical parameter for understanding the ionization behavior of pharmaceutical compounds. This study employs potentiometric titration as a precise method to elucidate the pKa values of diverse molecules. The experimental methodology involved a carefully controlled titration setup, utilizing a pH meter to monitor the titration curve and identify inflection points corresponding to the dissociation of acidic or basic functional groups.https://dergipark.org.tr/en/download/article-file/3684876pka valuespotentiometric titrationmedicinal chemistrypharmacokineticsdrug discovery. |
| spellingShingle | Safiye Nihal Aydoğdu Durişehvar Ünal Elucidating Ionization Behavior: Potentiometric Titration for Precise Determination of pKa Values in Medicinal Chemistry Pharmata pka values potentiometric titration medicinal chemistry pharmacokinetics drug discovery. |
| title | Elucidating Ionization Behavior: Potentiometric Titration for Precise Determination of pKa Values in Medicinal Chemistry |
| title_full | Elucidating Ionization Behavior: Potentiometric Titration for Precise Determination of pKa Values in Medicinal Chemistry |
| title_fullStr | Elucidating Ionization Behavior: Potentiometric Titration for Precise Determination of pKa Values in Medicinal Chemistry |
| title_full_unstemmed | Elucidating Ionization Behavior: Potentiometric Titration for Precise Determination of pKa Values in Medicinal Chemistry |
| title_short | Elucidating Ionization Behavior: Potentiometric Titration for Precise Determination of pKa Values in Medicinal Chemistry |
| title_sort | elucidating ionization behavior potentiometric titration for precise determination of pka values in medicinal chemistry |
| topic | pka values potentiometric titration medicinal chemistry pharmacokinetics drug discovery. |
| url | https://dergipark.org.tr/en/download/article-file/3684876 |
| work_keys_str_mv | AT safiyenihalaydogdu elucidatingionizationbehaviorpotentiometrictitrationforprecisedeterminationofpkavaluesinmedicinalchemistry AT durisehvarunal elucidatingionizationbehaviorpotentiometrictitrationforprecisedeterminationofpkavaluesinmedicinalchemistry |