Elucidating Ionization Behavior: Potentiometric Titration for Precise Determination of pKa Values in Medicinal Chemistry
The determination of pKa values holds paramount importance in the field of medicinal chemistry, serving as a critical parameter for understanding the ionization behavior of pharmaceutical compounds. This study employs potentiometric titration as a precise method to elucidate the pKa values of divers...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Atatürk University
2024-04-01
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| Series: | Pharmata |
| Subjects: | |
| Online Access: | https://dergipark.org.tr/en/download/article-file/3684876 |
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| Summary: | The determination of pKa values holds paramount importance in the field of medicinal chemistry, serving as a critical parameter for understanding the ionization behavior of pharmaceutical compounds. This study employs potentiometric titration as a precise method to elucidate the pKa values of diverse molecules. The experimental methodology involved a carefully controlled titration setup, utilizing a pH meter to monitor the titration curve and identify inflection points corresponding to the dissociation of acidic or basic functional groups. |
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| ISSN: | 2980-1966 |