Cytokine Storm in COVID-19 Patients, Its Impact on Organs and Potential Treatment by QTY Code-Designed Detergent-Free Chemokine Receptors
The novel coronavirus is not only causing respiratory problems, but it may also damage the heart, kidneys, liver, and other organs; in Wuhan, 14 to 30% of COVID-19 patients have lost their kidney function and now require either dialysis or kidney transplants. The novel coronavirus gains entry into h...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2020/8198963 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832546824284536832 |
|---|---|
| author | Mujahed I. Mustafa Abdelrahman H. Abdelmoneim Eiman M. Mahmoud Abdelrafie M. Makhawi |
| author_facet | Mujahed I. Mustafa Abdelrahman H. Abdelmoneim Eiman M. Mahmoud Abdelrafie M. Makhawi |
| author_sort | Mujahed I. Mustafa |
| collection | DOAJ |
| description | The novel coronavirus is not only causing respiratory problems, but it may also damage the heart, kidneys, liver, and other organs; in Wuhan, 14 to 30% of COVID-19 patients have lost their kidney function and now require either dialysis or kidney transplants. The novel coronavirus gains entry into humans by targeting the ACE2 receptor that found on lung cells, which destroy human lungs through cytokine storms, and this leads to hyperinflammation, forcing the immune cells to destroy healthy cells. This is why some COVID-19 patients need intensive care. The inflammatory chemicals released during COVID-19 infection cause the liver to produce proteins that defend the body from infections. However, these proteins can cause blood clotting, which can clog blood vessels in the heart and other organs; as a result, the organs are deprived of oxygen and nutrients which could ultimately lead to multiorgan failure and consequent progression to acute lung injury, acute respiratory distress syndrome, and often death. However, there are novel protein modification tools called the QTY code, which are similar in their structure to antibodies, which could provide a solution to excess cytokines. These synthetic proteins can be injected into the body to bind the excess cytokines created by the cytokine storm; this will eventually remove the excessive cytokines and inhibit the severe symptoms caused by the COVID-19 infection. In this review, we will focus on cytokine storm in COVID-19 patients, their impact on the body organs, and the potential treatment by QTY code-designed detergent-free chemokine receptors. |
| format | Article |
| id | doaj-art-9c9c94acc73a4300a97a9faa26cf81da |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-9c9c94acc73a4300a97a9faa26cf81da2025-02-03T06:47:04ZengWileyMediators of Inflammation0962-93511466-18612020-01-01202010.1155/2020/81989638198963Cytokine Storm in COVID-19 Patients, Its Impact on Organs and Potential Treatment by QTY Code-Designed Detergent-Free Chemokine ReceptorsMujahed I. Mustafa0Abdelrahman H. Abdelmoneim1Eiman M. Mahmoud2Abdelrafie M. Makhawi3Department of Biotechnology, University of Bahri, Khartoum, SudanFaculty of Medicine, Alneelain University, Khartoum, SudanDepartment of Immunology, Ahfad University for Women, Khartoum, SudanDepartment of Biotechnology, University of Bahri, Khartoum, SudanThe novel coronavirus is not only causing respiratory problems, but it may also damage the heart, kidneys, liver, and other organs; in Wuhan, 14 to 30% of COVID-19 patients have lost their kidney function and now require either dialysis or kidney transplants. The novel coronavirus gains entry into humans by targeting the ACE2 receptor that found on lung cells, which destroy human lungs through cytokine storms, and this leads to hyperinflammation, forcing the immune cells to destroy healthy cells. This is why some COVID-19 patients need intensive care. The inflammatory chemicals released during COVID-19 infection cause the liver to produce proteins that defend the body from infections. However, these proteins can cause blood clotting, which can clog blood vessels in the heart and other organs; as a result, the organs are deprived of oxygen and nutrients which could ultimately lead to multiorgan failure and consequent progression to acute lung injury, acute respiratory distress syndrome, and often death. However, there are novel protein modification tools called the QTY code, which are similar in their structure to antibodies, which could provide a solution to excess cytokines. These synthetic proteins can be injected into the body to bind the excess cytokines created by the cytokine storm; this will eventually remove the excessive cytokines and inhibit the severe symptoms caused by the COVID-19 infection. In this review, we will focus on cytokine storm in COVID-19 patients, their impact on the body organs, and the potential treatment by QTY code-designed detergent-free chemokine receptors.http://dx.doi.org/10.1155/2020/8198963 |
| spellingShingle | Mujahed I. Mustafa Abdelrahman H. Abdelmoneim Eiman M. Mahmoud Abdelrafie M. Makhawi Cytokine Storm in COVID-19 Patients, Its Impact on Organs and Potential Treatment by QTY Code-Designed Detergent-Free Chemokine Receptors Mediators of Inflammation |
| title | Cytokine Storm in COVID-19 Patients, Its Impact on Organs and Potential Treatment by QTY Code-Designed Detergent-Free Chemokine Receptors |
| title_full | Cytokine Storm in COVID-19 Patients, Its Impact on Organs and Potential Treatment by QTY Code-Designed Detergent-Free Chemokine Receptors |
| title_fullStr | Cytokine Storm in COVID-19 Patients, Its Impact on Organs and Potential Treatment by QTY Code-Designed Detergent-Free Chemokine Receptors |
| title_full_unstemmed | Cytokine Storm in COVID-19 Patients, Its Impact on Organs and Potential Treatment by QTY Code-Designed Detergent-Free Chemokine Receptors |
| title_short | Cytokine Storm in COVID-19 Patients, Its Impact on Organs and Potential Treatment by QTY Code-Designed Detergent-Free Chemokine Receptors |
| title_sort | cytokine storm in covid 19 patients its impact on organs and potential treatment by qty code designed detergent free chemokine receptors |
| url | http://dx.doi.org/10.1155/2020/8198963 |
| work_keys_str_mv | AT mujahedimustafa cytokinestormincovid19patientsitsimpactonorgansandpotentialtreatmentbyqtycodedesigneddetergentfreechemokinereceptors AT abdelrahmanhabdelmoneim cytokinestormincovid19patientsitsimpactonorgansandpotentialtreatmentbyqtycodedesigneddetergentfreechemokinereceptors AT eimanmmahmoud cytokinestormincovid19patientsitsimpactonorgansandpotentialtreatmentbyqtycodedesigneddetergentfreechemokinereceptors AT abdelrafiemmakhawi cytokinestormincovid19patientsitsimpactonorgansandpotentialtreatmentbyqtycodedesigneddetergentfreechemokinereceptors |