Pharmacokinetics, biological effects, and distribution of (1→3)-β-D-glucan in blood and organs in rabbits
The pharmacokinetics, biological effects and distribution in blood and organs of 125I-labeled (1→3)-β-D-glucan purified from Candida albicans were analyzed in rabbits during the 24-h period following an intravenous administration.The intravascular half-life of (1→3)-β- D-glucan was 1.8 min in the lo...
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| Format: | Article |
| Language: | English |
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Wiley
1997-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1080/09629359791622 |
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| _version_ | 1832561722818297856 |
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| author | Minoru Yoshida Robert I. Roth Carl Grunfeld Kenneth R. Feingold Jack Levin |
| author_facet | Minoru Yoshida Robert I. Roth Carl Grunfeld Kenneth R. Feingold Jack Levin |
| author_sort | Minoru Yoshida |
| collection | DOAJ |
| description | The pharmacokinetics, biological effects and distribution in blood and organs of 125I-labeled (1→3)-β-D-glucan purified from Candida albicans were analyzed in rabbits during the 24-h period following an intravenous administration.The intravascular half-life of (1→3)-β- D-glucan was 1.8 min in the low-dose group (9.3 μg/kg) and 1.4 min in the high-dose group (222 μg/kg), and the mean (±SD) total body clearance was 1.12 ± 0.30 and 1.17 ± 0.16 ml/min, respectively. The rabbits remained well and (1→3)-β-D-glucan failed to alter blood cell counts. Less than 3% of the 125I-(1→3)-β-D-glucan was initially associated with the cellular compartment, and this value decreased further during the 2-h period following administration
(P = 0.0001). Over 97% of 125I-(1→3)-β-D-glucan was associated with cell-free plasma, and the majority in plasma appeared to be present in the unbound form (not associated with lipoproteins or plasma proteins). The liver contained more than 80% of the 125I-(1→3)-β-D-glucan detected in the six major organs analyzed. |
| format | Article |
| id | doaj-art-9c989c6093234feda4a42459a34c077b |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1997-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-9c989c6093234feda4a42459a34c077b2025-02-03T01:24:26ZengWileyMediators of Inflammation0962-93511466-18611997-01-016427928310.1080/09629359791622Pharmacokinetics, biological effects, and distribution of (1→3)-β-D-glucan in blood and organs in rabbitsMinoru Yoshida0Robert I. Roth1Carl Grunfeld2Kenneth R. Feingold3Jack Levin4Fourth Depar tmentof Internal Medicine, Teikyo University School of Medicine, 74 Mizonokuchi, Takatsu-ku, Kawasaki City 213, JapanDepartment of Laboratory Medicine, Metabolism Section, University of California School of Medicine, the Veterans Administration Medical Center, San Francisco 94121, CA, USADepartment of Medicine, Metabolism Section, University of California School of Medicine, the Veterans Administration Medical Center, San Francisco 94121, CA, USADepartment of Medicine, Metabolism Section, University of California School of Medicine, the Veterans Administration Medical Center, San Francisco 94121, CA, USADepartment of Laboratory Medicine, Metabolism Section, University of California School of Medicine, the Veterans Administration Medical Center, San Francisco 94121, CA, USAThe pharmacokinetics, biological effects and distribution in blood and organs of 125I-labeled (1→3)-β-D-glucan purified from Candida albicans were analyzed in rabbits during the 24-h period following an intravenous administration.The intravascular half-life of (1→3)-β- D-glucan was 1.8 min in the low-dose group (9.3 μg/kg) and 1.4 min in the high-dose group (222 μg/kg), and the mean (±SD) total body clearance was 1.12 ± 0.30 and 1.17 ± 0.16 ml/min, respectively. The rabbits remained well and (1→3)-β-D-glucan failed to alter blood cell counts. Less than 3% of the 125I-(1→3)-β-D-glucan was initially associated with the cellular compartment, and this value decreased further during the 2-h period following administration (P = 0.0001). Over 97% of 125I-(1→3)-β-D-glucan was associated with cell-free plasma, and the majority in plasma appeared to be present in the unbound form (not associated with lipoproteins or plasma proteins). The liver contained more than 80% of the 125I-(1→3)-β-D-glucan detected in the six major organs analyzed.http://dx.doi.org/10.1080/09629359791622 |
| spellingShingle | Minoru Yoshida Robert I. Roth Carl Grunfeld Kenneth R. Feingold Jack Levin Pharmacokinetics, biological effects, and distribution of (1→3)-β-D-glucan in blood and organs in rabbits Mediators of Inflammation |
| title | Pharmacokinetics, biological effects, and distribution of (1→3)-β-D-glucan in blood and organs in rabbits |
| title_full | Pharmacokinetics, biological effects, and distribution of (1→3)-β-D-glucan in blood and organs in rabbits |
| title_fullStr | Pharmacokinetics, biological effects, and distribution of (1→3)-β-D-glucan in blood and organs in rabbits |
| title_full_unstemmed | Pharmacokinetics, biological effects, and distribution of (1→3)-β-D-glucan in blood and organs in rabbits |
| title_short | Pharmacokinetics, biological effects, and distribution of (1→3)-β-D-glucan in blood and organs in rabbits |
| title_sort | pharmacokinetics biological effects and distribution of 1 3 β d glucan in blood and organs in rabbits |
| url | http://dx.doi.org/10.1080/09629359791622 |
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