Dimethyl fumarate ameliorated pyroptosis in contrast-induced acute renal injury by regulating endoplasmic reticulum stress and JAK2-STAT3 pathway

Dimethyl fumarate ameliorated pyroptosis in contrast-induced acute renal injury by regulating endoplasmic reticulum stress and JAK2-STAT3 pathway

Background Inflammation and oxidative stress are important pathological processes of contrast-induced acute renal injury (CIAKI). This study explored whether DMF had therapeutic effects and investigated the underlying mechanism in CIAKI.Methods A CIAKI animal model was established in C57BL/6J mice w...

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Bibliographic Details
Main Authors: Xiaoning An, Min Yin, Yilan Shen, Xieyi Guo, Youhua Xu, Dongsheng Cheng, Dingkun Gui
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Renal Failure
Subjects:
Contrast-induced acute renal injury
dimethyl fumarate
endoplasmic reticulum stress
JAK2–STAT3 pathway
pyroptosis
Online Access:https://www.tandfonline.com/doi/10.1080/0886022X.2025.2504633
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