Heavy mechanical force decelerates orthodontic tooth movement via Piezo1-induced mitochondrial calcium down-regulation

Heavy mechanical force decelerates orthodontic tooth movement via Piezo1-induced mitochondrial calcium down-regulation

Orthodontic tooth movement (OTM) depends on periodontal ligament cells (PDLCs), which sense biomechanical stimuli and initiate alveolar bone remodeling. Light (optimal) forces accelerate OTM, whereas heavy forces decelerate it. However, the mechanisms by which PDLCs sense biomechanical stimuli and a...

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Bibliographic Details
Main Authors: Ye Zhu, Xuehuan Meng, Qiming Zhai, Liangjing Xin, Hao Tan, Xinyi He, Xiang Li, Guoyin Yang, Jinlin Song, Leilei Zheng
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-03-01
Series:Genes and Diseases
Subjects:
Biomechanics
Bone remodeling/regeneration
Mechanotransduction
Orthodontic tooth movement
Periodontal ligament
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304224002319
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