Expanding Horizons in Advancements of FRET Biosensing Technologies
Förster resonance energy transfer (FRET)-based biosensors are versatile tools for obtaining insights into various biological processes. Their working principles are based on nonradiative energy transfer from donor to acceptor fluorophores. This energy transfer is responsible for a change in fluoresc...
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MDPI AG
2025-07-01
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| Series: | Biosensors |
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| Online Access: | https://www.mdpi.com/2079-6374/15/7/452 |
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| author | Munazza Fatima Naseem Abbas |
| author_facet | Munazza Fatima Naseem Abbas |
| author_sort | Munazza Fatima |
| collection | DOAJ |
| description | Förster resonance energy transfer (FRET)-based biosensors are versatile tools for obtaining insights into various biological processes. Their working principles are based on nonradiative energy transfer from donor to acceptor fluorophores. This energy transfer is responsible for a change in fluorescence intensity, which provides a basis for the detection of biomolecules. Advantageous features of FRET biosensors include their high sensitivity and specificity. Recently, there have been notable developments to extend the usage of FRET biosensors for diverse applications. In this review, we briefly summarize the state-of-the-art developments of FRET biosensors for cellular imaging, drug discovery, pathogen detection, and cancer diagnosis. Continued research on biosensor design, donor acceptor pair optimization, and integration of innovative materials can further extend the applications of FRET biosensors across health care settings. |
| format | Article |
| id | doaj-art-9c8ecddbd7b8402ca4a8a30153ec9000 |
| institution | Kabale University |
| issn | 2079-6374 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj-art-9c8ecddbd7b8402ca4a8a30153ec90002025-08-20T03:58:25ZengMDPI AGBiosensors2079-63742025-07-0115745210.3390/bios15070452Expanding Horizons in Advancements of FRET Biosensing TechnologiesMunazza Fatima0Naseem Abbas1Department of Microbiology, College of Medicine, Gachon University, Incheon 21936, Republic of KoreaDepartment of Mechanical Engineering, Sejong University, Seoul 05006, Republic of KoreaFörster resonance energy transfer (FRET)-based biosensors are versatile tools for obtaining insights into various biological processes. Their working principles are based on nonradiative energy transfer from donor to acceptor fluorophores. This energy transfer is responsible for a change in fluorescence intensity, which provides a basis for the detection of biomolecules. Advantageous features of FRET biosensors include their high sensitivity and specificity. Recently, there have been notable developments to extend the usage of FRET biosensors for diverse applications. In this review, we briefly summarize the state-of-the-art developments of FRET biosensors for cellular imaging, drug discovery, pathogen detection, and cancer diagnosis. Continued research on biosensor design, donor acceptor pair optimization, and integration of innovative materials can further extend the applications of FRET biosensors across health care settings.https://www.mdpi.com/2079-6374/15/7/452FRETcellular imagingdrug discoverypathogen detectioncancer diagnosis |
| spellingShingle | Munazza Fatima Naseem Abbas Expanding Horizons in Advancements of FRET Biosensing Technologies Biosensors FRET cellular imaging drug discovery pathogen detection cancer diagnosis |
| title | Expanding Horizons in Advancements of FRET Biosensing Technologies |
| title_full | Expanding Horizons in Advancements of FRET Biosensing Technologies |
| title_fullStr | Expanding Horizons in Advancements of FRET Biosensing Technologies |
| title_full_unstemmed | Expanding Horizons in Advancements of FRET Biosensing Technologies |
| title_short | Expanding Horizons in Advancements of FRET Biosensing Technologies |
| title_sort | expanding horizons in advancements of fret biosensing technologies |
| topic | FRET cellular imaging drug discovery pathogen detection cancer diagnosis |
| url | https://www.mdpi.com/2079-6374/15/7/452 |
| work_keys_str_mv | AT munazzafatima expandinghorizonsinadvancementsoffretbiosensingtechnologies AT naseemabbas expandinghorizonsinadvancementsoffretbiosensingtechnologies |