Immune Suppression in Head and Neck Cancers: A Review
Head and neck squamous cell carcinomas (HNSCCs) are the sixth most common cancer in the world. Despite significant advances in the treatment modalities involving surgery, radiotherapy, and concomitant chemoradiotherapy, the 5-year survival rate remained below 50% for the past 30 years. The worse pro...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2010/701657 |
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| author | Anaëlle Duray Stéphanie Demoulin Pascale Hubert Philippe Delvenne Sven Saussez |
| author_facet | Anaëlle Duray Stéphanie Demoulin Pascale Hubert Philippe Delvenne Sven Saussez |
| author_sort | Anaëlle Duray |
| collection | DOAJ |
| description | Head and neck squamous cell carcinomas (HNSCCs) are the sixth most common cancer in the world. Despite significant advances in the treatment modalities involving surgery, radiotherapy, and concomitant chemoradiotherapy, the 5-year survival rate remained below 50% for the past 30 years. The worse prognosis of these cancers must certainly be link to the fact that HNSCCs strongly influence the host immune system. We present a critical review of our understanding of the HNSCC escape to the antitumor immune response such as a downregulation of HLA class I and/or components of APM. Antitumor responses of HNSCC patients are compromised in the presence of functional defects or apoptosis of T-cells, both circulating and tumor-infiltrating. Langerhans cells are increased in the first steps of the carcinogenesis but decreased in invasive carcinomas. The accumulation of macrophages in the peritumoral areas seems to play a protumoral role by secreting VEGF and stimulating the neoangiogenesis. |
| format | Article |
| id | doaj-art-9c84e36263544d2ea6e8cc991f95f092 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-9c84e36263544d2ea6e8cc991f95f0922025-08-20T03:38:22ZengWileyClinical and Developmental Immunology1740-25221740-25302010-01-01201010.1155/2010/701657701657Immune Suppression in Head and Neck Cancers: A ReviewAnaëlle Duray0Stéphanie Demoulin1Pascale Hubert2Philippe Delvenne3Sven Saussez4Laboratory of Anatomy, Faculty of Medicine and Pharmacy, University of Mons, 7000 Mons, BelgiumDepartment of Pathology, CHU Sart-Tilman, University of Liège, 4000 Liège, BelgiumDepartment of Pathology, CHU Sart-Tilman, University of Liège, 4000 Liège, BelgiumDepartment of Pathology, CHU Sart-Tilman, University of Liège, 4000 Liège, BelgiumLaboratory of Anatomy, Faculty of Medicine and Pharmacy, University of Mons, 7000 Mons, BelgiumHead and neck squamous cell carcinomas (HNSCCs) are the sixth most common cancer in the world. Despite significant advances in the treatment modalities involving surgery, radiotherapy, and concomitant chemoradiotherapy, the 5-year survival rate remained below 50% for the past 30 years. The worse prognosis of these cancers must certainly be link to the fact that HNSCCs strongly influence the host immune system. We present a critical review of our understanding of the HNSCC escape to the antitumor immune response such as a downregulation of HLA class I and/or components of APM. Antitumor responses of HNSCC patients are compromised in the presence of functional defects or apoptosis of T-cells, both circulating and tumor-infiltrating. Langerhans cells are increased in the first steps of the carcinogenesis but decreased in invasive carcinomas. The accumulation of macrophages in the peritumoral areas seems to play a protumoral role by secreting VEGF and stimulating the neoangiogenesis.http://dx.doi.org/10.1155/2010/701657 |
| spellingShingle | Anaëlle Duray Stéphanie Demoulin Pascale Hubert Philippe Delvenne Sven Saussez Immune Suppression in Head and Neck Cancers: A Review Clinical and Developmental Immunology |
| title | Immune Suppression in Head and Neck Cancers: A Review |
| title_full | Immune Suppression in Head and Neck Cancers: A Review |
| title_fullStr | Immune Suppression in Head and Neck Cancers: A Review |
| title_full_unstemmed | Immune Suppression in Head and Neck Cancers: A Review |
| title_short | Immune Suppression in Head and Neck Cancers: A Review |
| title_sort | immune suppression in head and neck cancers a review |
| url | http://dx.doi.org/10.1155/2010/701657 |
| work_keys_str_mv | AT anaelleduray immunesuppressioninheadandneckcancersareview AT stephaniedemoulin immunesuppressioninheadandneckcancersareview AT pascalehubert immunesuppressioninheadandneckcancersareview AT philippedelvenne immunesuppressioninheadandneckcancersareview AT svensaussez immunesuppressioninheadandneckcancersareview |