Treatment of Fibromyalgia - duloxetine or pregabalin?
Introduction: Fibromyalgia (FM) is a complex and chronic condition characterized by widespread pain, fatigue, and disrupted sleep, often accompanied by mood disturbances and cognitive difficulties. The pathophysiology of FM involves heightened pain sensitivity, altered neurotransmitter levels, and...
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| Format: | Article |
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Kazimierz Wielki University
2025-04-01
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| Series: | Journal of Education, Health and Sport |
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| Online Access: | https://apcz.umk.pl/JEHS/article/view/57856 |
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| author | Magdalena Bujak Natalia Rulewska Filip Grabowski Jakub Siemko Dagmara Neska Dominika Prystacka-Szar Justyna Stadler-Szajda Adrianna Czyżnikiewicz Wenancjusz Stołowski Magdalena Waśniowska |
| author_facet | Magdalena Bujak Natalia Rulewska Filip Grabowski Jakub Siemko Dagmara Neska Dominika Prystacka-Szar Justyna Stadler-Szajda Adrianna Czyżnikiewicz Wenancjusz Stołowski Magdalena Waśniowska |
| author_sort | Magdalena Bujak |
| collection | DOAJ |
| description |
Introduction: Fibromyalgia (FM) is a complex and chronic condition characterized by widespread pain, fatigue, and disrupted sleep, often accompanied by mood disturbances and cognitive difficulties. The pathophysiology of FM involves heightened pain sensitivity, altered neurotransmitter levels, and neurochemical imbalances, including elevated substance P and glutamate. Duloxetine, a serotonin-norepinephrine reuptake inhibitor (SNRI), has demonstrated efficacy in managing FM symptoms, particularly pain, functional impairment, and quality of life. Pregabalin, another widely used FM medication, reduces pain by modulating calcium channels and neurotransmitter release, improving sleep and reducing fatigue. Comparative studies indicate that duloxetine may offer broader benefits, including reduced healthcare utilization, due to its dual role in pain relief and mood stabilization. While pregabalin may be preferred in patients with specific comorbidities like functional dyspepsia, duloxetine’s antidepressant effects make it a compelling option for individuals with depression-related FM symptoms.
Aim of the study: The study aimed to analyze the current treatment of Fibromyalgia and compare two main treatment methods, duloxetine and pregabalin.
Review method: The following keywords, such as fibromyalgia treatment, duloxetine, and pregabalin, have been included in the search phrases used to thoroughly examine research publications available on Pubmed.
Conclusion: This review highlights the importance of personalized treatment strategies for FM, integrating pharmacological and non-pharmacological approaches within a biopsychosocial framework. By tailoring therapies to individual needs, clinicians can optimize outcomes and improve patient quality of life.
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| format | Article |
| id | doaj-art-9c7da32bc5bc424b8ad836cc114f2784 |
| institution | DOAJ |
| issn | 2391-8306 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj-art-9c7da32bc5bc424b8ad836cc114f27842025-08-20T03:06:08ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062025-04-018010.12775/JEHS.2025.80.57856Treatment of Fibromyalgia - duloxetine or pregabalin?Magdalena Bujak0https://orcid.org/0009-0008-9274-3595Natalia Rulewska1https://orcid.org/0009-0008-4515-7403Filip Grabowski2https://orcid.org/0009-0007-0466-2764Jakub Siemko3https://orcid.org/0009-0009-9318-9458Dagmara Neska4https://orcid.org/0009-0003-1900-954XDominika Prystacka-Szar5https://orcid.org/0009-0003-6533-4247Justyna Stadler-Szajda6https://orcid.org/0000-0002-1742-1835Adrianna Czyżnikiewicz7https://orcid.org/0009-0007-4541-7175Wenancjusz Stołowski8https://orcid.org/0009-0009-0317-1212Magdalena Waśniowska9https://orcid.org/0009-0006-0614-8307Krakow University HospitalProvincial Specialist Hospital in Ciechanów Provincial Specialist Hospital in Ciechanów Ludwika Błażka Provincial Multi-Specialist Hospital in InowrocławLudwika Błażka Provincial Multi-Specialist Hospital in InowrocławLudwik Rydygier Memorial Specialized Hospital in KrakowLudwika Błażka Provincial Multi-Specialist Hospital in InowrocławLudwika Błażka Provincial Multi-Specialist Hospital in InowrocławLudwika Błażka Provincial Multi-Specialist Hospital in InowrocławStefana Żeromskiego Specialist Hospital in Kraków Introduction: Fibromyalgia (FM) is a complex and chronic condition characterized by widespread pain, fatigue, and disrupted sleep, often accompanied by mood disturbances and cognitive difficulties. The pathophysiology of FM involves heightened pain sensitivity, altered neurotransmitter levels, and neurochemical imbalances, including elevated substance P and glutamate. Duloxetine, a serotonin-norepinephrine reuptake inhibitor (SNRI), has demonstrated efficacy in managing FM symptoms, particularly pain, functional impairment, and quality of life. Pregabalin, another widely used FM medication, reduces pain by modulating calcium channels and neurotransmitter release, improving sleep and reducing fatigue. Comparative studies indicate that duloxetine may offer broader benefits, including reduced healthcare utilization, due to its dual role in pain relief and mood stabilization. While pregabalin may be preferred in patients with specific comorbidities like functional dyspepsia, duloxetine’s antidepressant effects make it a compelling option for individuals with depression-related FM symptoms. Aim of the study: The study aimed to analyze the current treatment of Fibromyalgia and compare two main treatment methods, duloxetine and pregabalin. Review method: The following keywords, such as fibromyalgia treatment, duloxetine, and pregabalin, have been included in the search phrases used to thoroughly examine research publications available on Pubmed. Conclusion: This review highlights the importance of personalized treatment strategies for FM, integrating pharmacological and non-pharmacological approaches within a biopsychosocial framework. By tailoring therapies to individual needs, clinicians can optimize outcomes and improve patient quality of life. https://apcz.umk.pl/JEHS/article/view/57856Fibromyalgiatreatmentduloxetinepregabalin |
| spellingShingle | Magdalena Bujak Natalia Rulewska Filip Grabowski Jakub Siemko Dagmara Neska Dominika Prystacka-Szar Justyna Stadler-Szajda Adrianna Czyżnikiewicz Wenancjusz Stołowski Magdalena Waśniowska Treatment of Fibromyalgia - duloxetine or pregabalin? Journal of Education, Health and Sport Fibromyalgia treatment duloxetine pregabalin |
| title | Treatment of Fibromyalgia - duloxetine or pregabalin? |
| title_full | Treatment of Fibromyalgia - duloxetine or pregabalin? |
| title_fullStr | Treatment of Fibromyalgia - duloxetine or pregabalin? |
| title_full_unstemmed | Treatment of Fibromyalgia - duloxetine or pregabalin? |
| title_short | Treatment of Fibromyalgia - duloxetine or pregabalin? |
| title_sort | treatment of fibromyalgia duloxetine or pregabalin |
| topic | Fibromyalgia treatment duloxetine pregabalin |
| url | https://apcz.umk.pl/JEHS/article/view/57856 |
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