The Role of 5-Lipoxygenase and Leukotrienes in Shock and Ischemia-Reperfusion Injury
The leukotrienes (LTs) are metabolic products of arachidonic acid via the 5-lipoxygenase (5-LO) pathway. The biological activities of LTs suggest that they are mediators of acute inflammatory and immediate hypersensitivity responses. In particular, the 5-LO activation has been proposed to be an impo...
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| Format: | Article |
| Language: | English |
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Wiley
2007-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2007.34 |
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| author | Antonietta Rossi Carlo Pergola Salvatore Cuzzocrea Lidia Sautebin |
| author_facet | Antonietta Rossi Carlo Pergola Salvatore Cuzzocrea Lidia Sautebin |
| author_sort | Antonietta Rossi |
| collection | DOAJ |
| description | The leukotrienes (LTs) are metabolic products of arachidonic acid via the 5-lipoxygenase (5-LO) pathway. The biological activities of LTs suggest that they are mediators of acute inflammatory and immediate hypersensitivity responses. In particular, the 5-LO activation has been proposed to be an important regulator for pathogenesis in multicellular organisms. The role of LTs in tissue damage, associated with septic and nonseptic shock and ischemia-reperfusion, has been extensively studied by the use of 5-LO inhibitors, receptor antagonists, and mice with a targeted disruption of the 5-LO gene (5-LOKO). In particular, several data indicate that LTs regulate neutrophil trafficking in damaged tissue in shock and ischemia-reperfusion, mainly through the modulation of adhesion molecule expression. This concept may provide new insights into the interpretation of the protective effect of 5-LO inhibition, which may be useful in the therapy of pathological conditions associated with septic and nonseptic shock and ischemia-reperfusion injury. |
| format | Article |
| id | doaj-art-9c7bafbca4c94fa68c99dcc110513301 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2007-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-9c7bafbca4c94fa68c99dcc1105133012025-02-03T01:13:14ZengWileyThe Scientific World Journal1537-744X2007-01-017567410.1100/tsw.2007.34The Role of 5-Lipoxygenase and Leukotrienes in Shock and Ischemia-Reperfusion InjuryAntonietta Rossi0Carlo Pergola1Salvatore Cuzzocrea2Lidia Sautebin3Department of Experimental Pharmacology, University of Naples Federico II, Naples, ItalyDepartment of Experimental Pharmacology, University of Naples Federico II, Naples, ItalyIRCCS Centro Neurolesi “Bonino-Pulejo”, Messina, ItalyDepartment of Experimental Pharmacology, University of Naples Federico II, Naples, ItalyThe leukotrienes (LTs) are metabolic products of arachidonic acid via the 5-lipoxygenase (5-LO) pathway. The biological activities of LTs suggest that they are mediators of acute inflammatory and immediate hypersensitivity responses. In particular, the 5-LO activation has been proposed to be an important regulator for pathogenesis in multicellular organisms. The role of LTs in tissue damage, associated with septic and nonseptic shock and ischemia-reperfusion, has been extensively studied by the use of 5-LO inhibitors, receptor antagonists, and mice with a targeted disruption of the 5-LO gene (5-LOKO). In particular, several data indicate that LTs regulate neutrophil trafficking in damaged tissue in shock and ischemia-reperfusion, mainly through the modulation of adhesion molecule expression. This concept may provide new insights into the interpretation of the protective effect of 5-LO inhibition, which may be useful in the therapy of pathological conditions associated with septic and nonseptic shock and ischemia-reperfusion injury.http://dx.doi.org/10.1100/tsw.2007.34 |
| spellingShingle | Antonietta Rossi Carlo Pergola Salvatore Cuzzocrea Lidia Sautebin The Role of 5-Lipoxygenase and Leukotrienes in Shock and Ischemia-Reperfusion Injury The Scientific World Journal |
| title | The Role of 5-Lipoxygenase and Leukotrienes in Shock and Ischemia-Reperfusion Injury |
| title_full | The Role of 5-Lipoxygenase and Leukotrienes in Shock and Ischemia-Reperfusion Injury |
| title_fullStr | The Role of 5-Lipoxygenase and Leukotrienes in Shock and Ischemia-Reperfusion Injury |
| title_full_unstemmed | The Role of 5-Lipoxygenase and Leukotrienes in Shock and Ischemia-Reperfusion Injury |
| title_short | The Role of 5-Lipoxygenase and Leukotrienes in Shock and Ischemia-Reperfusion Injury |
| title_sort | role of 5 lipoxygenase and leukotrienes in shock and ischemia reperfusion injury |
| url | http://dx.doi.org/10.1100/tsw.2007.34 |
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