Disease-specific B cell clones are shared between patients with Crohn’s disease

Disease-specific B cell clones are shared between patients with Crohn’s disease

Abstract B cells have important functions in gut homeostasis, and dysregulated B cell populations are frequently observed in patients with inflammatory bowel diseases, including both ulcerative colitis (UC) and Crohn’s disease (CD). How these B cell perturbations contribute to disease remains largel...

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Main Authors: Prasanti Kotagiri, William M. Rae, Laura Bergamaschi, Diana Pombal, Ji-Yeun Lee, Nurulamin M. Noor, Raoul S. Sojwal, Samuel J. S. Rubin, Lukas W. Unger, Sofie H. Tolmeijer, Giulia Manferrari, Rachael J. M. Bashford-Rogers, David B. Bingham, Anton Stift, Stephan Rogalla, John Gubatan, James C. Lee, Kenneth G. C. Smith, Eoin F. McKinney, Scott D. Boyd, Paul A. Lyons
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58977-y
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