Disease-specific B cell clones are shared between patients with Crohn’s disease
Abstract B cells have important functions in gut homeostasis, and dysregulated B cell populations are frequently observed in patients with inflammatory bowel diseases, including both ulcerative colitis (UC) and Crohn’s disease (CD). How these B cell perturbations contribute to disease remains largel...
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Nature Portfolio
2025-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-58977-y |
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| author | Prasanti Kotagiri William M. Rae Laura Bergamaschi Diana Pombal Ji-Yeun Lee Nurulamin M. Noor Raoul S. Sojwal Samuel J. S. Rubin Lukas W. Unger Sofie H. Tolmeijer Giulia Manferrari Rachael J. M. Bashford-Rogers David B. Bingham Anton Stift Stephan Rogalla John Gubatan James C. Lee Kenneth G. C. Smith Eoin F. McKinney Scott D. Boyd Paul A. Lyons |
| author_facet | Prasanti Kotagiri William M. Rae Laura Bergamaschi Diana Pombal Ji-Yeun Lee Nurulamin M. Noor Raoul S. Sojwal Samuel J. S. Rubin Lukas W. Unger Sofie H. Tolmeijer Giulia Manferrari Rachael J. M. Bashford-Rogers David B. Bingham Anton Stift Stephan Rogalla John Gubatan James C. Lee Kenneth G. C. Smith Eoin F. McKinney Scott D. Boyd Paul A. Lyons |
| author_sort | Prasanti Kotagiri |
| collection | DOAJ |
| description | Abstract B cells have important functions in gut homeostasis, and dysregulated B cell populations are frequently observed in patients with inflammatory bowel diseases, including both ulcerative colitis (UC) and Crohn’s disease (CD). How these B cell perturbations contribute to disease remains largely unknown. Here, we perform deep sequencing of the B cell receptor (BCR) repertoire in four cohorts of patients with CD, together with healthy controls and patients with UC. We identify BCR clones that are shared between patients with CD but not found in healthy individuals nor in patients with UC, indicating CD-associated B cell immune responses. Shared clones are present in the inflamed gut mucosa, draining intestinal lymph nodes and blood, suggesting the presence of common CD-associated antigens that drive B cell responses in CD patients. |
| format | Article |
| id | doaj-art-9c7b7d6013a040bfa33c1f92165d22e1 |
| institution | OA Journals |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-9c7b7d6013a040bfa33c1f92165d22e12025-08-20T02:28:09ZengNature PortfolioNature Communications2041-17232025-04-0116111310.1038/s41467-025-58977-yDisease-specific B cell clones are shared between patients with Crohn’s diseasePrasanti Kotagiri0William M. Rae1Laura Bergamaschi2Diana Pombal3Ji-Yeun Lee4Nurulamin M. Noor5Raoul S. Sojwal6Samuel J. S. Rubin7Lukas W. Unger8Sofie H. Tolmeijer9Giulia Manferrari10Rachael J. M. Bashford-Rogers11David B. Bingham12Anton Stift13Stephan Rogalla14John Gubatan15James C. Lee16Kenneth G. C. Smith17Eoin F. McKinney18Scott D. Boyd19Paul A. Lyons20Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of CambridgeCambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of CambridgeCambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of CambridgeDepartment of Medicine, University of Cambridge School of Clinical MedicineDepartment of Pathology, Stanford UniversityDepartment of Medicine, University of Cambridge School of Clinical MedicineDivision of Gastroenterology and Hepatology, Stanford UniversityDivision of Gastroenterology and Hepatology, Stanford UniversityCambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of CambridgeDepartment of Medicine, University of Cambridge School of Clinical MedicineDepartment of Medicine, University of Cambridge School of Clinical MedicineDepartment of Medicine, University of Cambridge School of Clinical MedicineDepartment of Pathology, Stanford UniversityDivision of Visceral Surgery, Department of General Surgery, Medical University of ViennaDivision of Gastroenterology and Hepatology, Stanford UniversityDivision of Gastroenterology and Hepatology, Stanford UniversityCambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of CambridgeCambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of CambridgeCambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of CambridgeDepartment of Pathology, Stanford UniversityCambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of CambridgeAbstract B cells have important functions in gut homeostasis, and dysregulated B cell populations are frequently observed in patients with inflammatory bowel diseases, including both ulcerative colitis (UC) and Crohn’s disease (CD). How these B cell perturbations contribute to disease remains largely unknown. Here, we perform deep sequencing of the B cell receptor (BCR) repertoire in four cohorts of patients with CD, together with healthy controls and patients with UC. We identify BCR clones that are shared between patients with CD but not found in healthy individuals nor in patients with UC, indicating CD-associated B cell immune responses. Shared clones are present in the inflamed gut mucosa, draining intestinal lymph nodes and blood, suggesting the presence of common CD-associated antigens that drive B cell responses in CD patients.https://doi.org/10.1038/s41467-025-58977-y |
| spellingShingle | Prasanti Kotagiri William M. Rae Laura Bergamaschi Diana Pombal Ji-Yeun Lee Nurulamin M. Noor Raoul S. Sojwal Samuel J. S. Rubin Lukas W. Unger Sofie H. Tolmeijer Giulia Manferrari Rachael J. M. Bashford-Rogers David B. Bingham Anton Stift Stephan Rogalla John Gubatan James C. Lee Kenneth G. C. Smith Eoin F. McKinney Scott D. Boyd Paul A. Lyons Disease-specific B cell clones are shared between patients with Crohn’s disease Nature Communications |
| title | Disease-specific B cell clones are shared between patients with Crohn’s disease |
| title_full | Disease-specific B cell clones are shared between patients with Crohn’s disease |
| title_fullStr | Disease-specific B cell clones are shared between patients with Crohn’s disease |
| title_full_unstemmed | Disease-specific B cell clones are shared between patients with Crohn’s disease |
| title_short | Disease-specific B cell clones are shared between patients with Crohn’s disease |
| title_sort | disease specific b cell clones are shared between patients with crohn s disease |
| url | https://doi.org/10.1038/s41467-025-58977-y |
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