Exploring Stressors: Impact on Cellular Organelles and Implications for Cellular Functions
Cellular stressors have been demonstrated to exert a substantial influence on the functionality of organelles, thereby impacting cellular homeostasis and contributing to the development of disease pathogenesis. This review aims to examine the impact of diverse stressors, including environmental, che...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-04-01
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| Series: | Stresses |
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| Online Access: | https://www.mdpi.com/2673-7140/5/2/26 |
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| author | Zoofa Zayani Arash Matinahmadi Alireza Tavakolpournegari Seyed Hesamoddin Bidooki |
| author_facet | Zoofa Zayani Arash Matinahmadi Alireza Tavakolpournegari Seyed Hesamoddin Bidooki |
| author_sort | Zoofa Zayani |
| collection | DOAJ |
| description | Cellular stressors have been demonstrated to exert a substantial influence on the functionality of organelles, thereby impacting cellular homeostasis and contributing to the development of disease pathogenesis. This review aims to examine the impact of diverse stressors, including environmental, chemical, biological, and physical factors, on critical organelles such as the cell membrane, mitochondria, endoplasmic reticulum, Golgi apparatus, lysosomes, and membrane-less organelles. The intricate molecular mechanisms underlying cellular stress responses, encompassing oxidative stress, protein misfolding, and metabolic reprogramming, have the capacity to elicit adaptive responses or culminate in pathological conditions. The interplay between these stressors and organelle dysfunction has been implicated in a myriad of diseases, including neurodegenerative disorders, cancer, metabolic disorders, and immune-related pathologies. A comprehensive understanding of the mechanisms by which organelles respond to stress can offer valuable insights into the development of therapeutic strategies aimed at mitigating cellular damage. |
| format | Article |
| id | doaj-art-9c7b3d2745d241c0bab100ffce6928a9 |
| institution | Kabale University |
| issn | 2673-7140 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Stresses |
| spelling | doaj-art-9c7b3d2745d241c0bab100ffce6928a92025-08-20T03:29:39ZengMDPI AGStresses2673-71402025-04-01522610.3390/stresses5020026Exploring Stressors: Impact on Cellular Organelles and Implications for Cellular FunctionsZoofa Zayani0Arash Matinahmadi1Alireza Tavakolpournegari2Seyed Hesamoddin Bidooki3Centre for Modern Interdisciplinary Technologies, Nicolaus Copernicus University, 87-100 Torun, PolandDepartment of Cellular and Molecular Biology, Nicolaus Copernicus University, 87-100 Torun, PolandDepartment of Toxicology and Cancer Biology, University of Kentucky College of Medicine, Lexington, KY 40536, USADepartment of Biochemistry and Molecular and Cellular Biology, Faculty of Veterinary Medicine, Health Research Institute of Aragon, University of Zaragoza, 50013 Zaragoza, SpainCellular stressors have been demonstrated to exert a substantial influence on the functionality of organelles, thereby impacting cellular homeostasis and contributing to the development of disease pathogenesis. This review aims to examine the impact of diverse stressors, including environmental, chemical, biological, and physical factors, on critical organelles such as the cell membrane, mitochondria, endoplasmic reticulum, Golgi apparatus, lysosomes, and membrane-less organelles. The intricate molecular mechanisms underlying cellular stress responses, encompassing oxidative stress, protein misfolding, and metabolic reprogramming, have the capacity to elicit adaptive responses or culminate in pathological conditions. The interplay between these stressors and organelle dysfunction has been implicated in a myriad of diseases, including neurodegenerative disorders, cancer, metabolic disorders, and immune-related pathologies. A comprehensive understanding of the mechanisms by which organelles respond to stress can offer valuable insights into the development of therapeutic strategies aimed at mitigating cellular damage.https://www.mdpi.com/2673-7140/5/2/26cellular stressorscell membranemitochondriaendoplasmic reticulumGolgi apparatuslysosomes |
| spellingShingle | Zoofa Zayani Arash Matinahmadi Alireza Tavakolpournegari Seyed Hesamoddin Bidooki Exploring Stressors: Impact on Cellular Organelles and Implications for Cellular Functions Stresses cellular stressors cell membrane mitochondria endoplasmic reticulum Golgi apparatus lysosomes |
| title | Exploring Stressors: Impact on Cellular Organelles and Implications for Cellular Functions |
| title_full | Exploring Stressors: Impact on Cellular Organelles and Implications for Cellular Functions |
| title_fullStr | Exploring Stressors: Impact on Cellular Organelles and Implications for Cellular Functions |
| title_full_unstemmed | Exploring Stressors: Impact on Cellular Organelles and Implications for Cellular Functions |
| title_short | Exploring Stressors: Impact on Cellular Organelles and Implications for Cellular Functions |
| title_sort | exploring stressors impact on cellular organelles and implications for cellular functions |
| topic | cellular stressors cell membrane mitochondria endoplasmic reticulum Golgi apparatus lysosomes |
| url | https://www.mdpi.com/2673-7140/5/2/26 |
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