Secondary Osteoporosis in Patients with Juvenile Idiopathic Arthritis
Bone disease in patients with juvenile idiopathic arthritis (JIA) is associated with focal (joint erosion and juxtaarticular osteopenia) and systemic bone loss (generalized osteopenia or reduction of bone mass density). Pathophysiology of bone loss is multifactorial and involves particularly proinfl...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Osteoporosis |
| Online Access: | http://dx.doi.org/10.4061/2011/569417 |
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| _version_ | 1850179454899322880 |
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| author | Kristyna Brabnikova Maresova |
| author_facet | Kristyna Brabnikova Maresova |
| author_sort | Kristyna Brabnikova Maresova |
| collection | DOAJ |
| description | Bone disease in patients with juvenile idiopathic arthritis (JIA) is associated with focal (joint erosion and juxtaarticular osteopenia) and systemic bone loss (generalized osteopenia or reduction of bone mass density). Pathophysiology of bone loss is multifactorial and involves particularly proinflammatory cytokines and deleterious effects of glucocorticoid therapy. Clinical studies in patients with JIA indicate excessive activation of osteoclastogenesis and reduction of bone formation. Reduction of physical activity, muscle atrophy caused by high disease activity, and compulsory restriction in movements are also associated with bone loss. In patients with JIA, the disease can be complicated by growth cartilage involvement and systemic or local growth retardation. In the absence of preventive measures, fragility fractures can occur even at an early age. |
| format | Article |
| id | doaj-art-9c7ae89e26684d8eac884cdab33c5b49 |
| institution | OA Journals |
| issn | 2042-0064 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Osteoporosis |
| spelling | doaj-art-9c7ae89e26684d8eac884cdab33c5b492025-08-20T02:18:28ZengWileyJournal of Osteoporosis2042-00642011-01-01201110.4061/2011/569417569417Secondary Osteoporosis in Patients with Juvenile Idiopathic ArthritisKristyna Brabnikova Maresova0Institute of Rheumatology, Slupi 4, 128 50, Prague 2, Czech RepublicBone disease in patients with juvenile idiopathic arthritis (JIA) is associated with focal (joint erosion and juxtaarticular osteopenia) and systemic bone loss (generalized osteopenia or reduction of bone mass density). Pathophysiology of bone loss is multifactorial and involves particularly proinflammatory cytokines and deleterious effects of glucocorticoid therapy. Clinical studies in patients with JIA indicate excessive activation of osteoclastogenesis and reduction of bone formation. Reduction of physical activity, muscle atrophy caused by high disease activity, and compulsory restriction in movements are also associated with bone loss. In patients with JIA, the disease can be complicated by growth cartilage involvement and systemic or local growth retardation. In the absence of preventive measures, fragility fractures can occur even at an early age.http://dx.doi.org/10.4061/2011/569417 |
| spellingShingle | Kristyna Brabnikova Maresova Secondary Osteoporosis in Patients with Juvenile Idiopathic Arthritis Journal of Osteoporosis |
| title | Secondary Osteoporosis in Patients with Juvenile Idiopathic Arthritis |
| title_full | Secondary Osteoporosis in Patients with Juvenile Idiopathic Arthritis |
| title_fullStr | Secondary Osteoporosis in Patients with Juvenile Idiopathic Arthritis |
| title_full_unstemmed | Secondary Osteoporosis in Patients with Juvenile Idiopathic Arthritis |
| title_short | Secondary Osteoporosis in Patients with Juvenile Idiopathic Arthritis |
| title_sort | secondary osteoporosis in patients with juvenile idiopathic arthritis |
| url | http://dx.doi.org/10.4061/2011/569417 |
| work_keys_str_mv | AT kristynabrabnikovamaresova secondaryosteoporosisinpatientswithjuvenileidiopathicarthritis |