Pancreatic ductal adenocarcinoma with inferior vena cava invasion: a report of three resected cases
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) often infiltrates to the adjacent major vasculatures; however, direct invasion of PDAC to the inferior vena cava (IVC) is uncommon. Case presentation We report our experience with three cases of PDAC directly invading the IVC wall. All thre...
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| Language: | English |
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Japan Surgical Society
2017-05-01
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| Series: | Surgical Case Reports |
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| Online Access: | http://link.springer.com/article/10.1186/s40792-017-0348-5 |
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| author | Takuya Mizumoto Tadahiro Goto Hirochika Toyama Keitaro Sofue Sadaki Asari Sachio Terai Motofumi Tanaka Masahiro Kido Tetsuo Ajiki Takumi Fukumoto Yonson Ku |
| author_facet | Takuya Mizumoto Tadahiro Goto Hirochika Toyama Keitaro Sofue Sadaki Asari Sachio Terai Motofumi Tanaka Masahiro Kido Tetsuo Ajiki Takumi Fukumoto Yonson Ku |
| author_sort | Takuya Mizumoto |
| collection | DOAJ |
| description | Abstract Background Pancreatic ductal adenocarcinoma (PDAC) often infiltrates to the adjacent major vasculatures; however, direct invasion of PDAC to the inferior vena cava (IVC) is uncommon. Case presentation We report our experience with three cases of PDAC directly invading the IVC wall. All three patients underwent pancreatoduodenectomy along with wedge resection of the IVC wall without severe postoperative complications. Histopathological studies revealed tumor infiltration to the adventitia of the IVC. All patients achieved negative surgical margins. One patient was still alive 26 months after surgery without tumor recurrence. Two patients experienced recurrence; one patient experienced liver metastasis but was still alive and in a stable condition without further tumor progression 12 months after surgery. Another patient experienced multiple liver metastasis 10 months after surgery and died 26 months after surgery. Conclusions Pancreatoduodenectomy along with wedge resection of the IVC wall for patients with PDAC directly invading the adventitia of the IVC can be performed safely. Further accumulation of cases is needed to elucidate the prognostic impact of IVC invasion. |
| format | Article |
| id | doaj-art-9c78ef6f2ea443e58d6cc569469ab806 |
| institution | DOAJ |
| issn | 2198-7793 |
| language | English |
| publishDate | 2017-05-01 |
| publisher | Japan Surgical Society |
| record_format | Article |
| series | Surgical Case Reports |
| spelling | doaj-art-9c78ef6f2ea443e58d6cc569469ab8062025-08-20T02:52:09ZengJapan Surgical SocietySurgical Case Reports2198-77932017-05-01311510.1186/s40792-017-0348-5Pancreatic ductal adenocarcinoma with inferior vena cava invasion: a report of three resected casesTakuya Mizumoto0Tadahiro Goto1Hirochika Toyama2Keitaro Sofue3Sadaki Asari4Sachio Terai5Motofumi Tanaka6Masahiro Kido7Tetsuo Ajiki8Takumi Fukumoto9Yonson Ku10Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of MedicineDivision of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of MedicineDivision of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of MedicineDivision of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of MedicineDivision of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of MedicineDivision of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of MedicineDivision of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of MedicineDivision of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of MedicineDivision of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of MedicineDivision of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of MedicineDivision of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of MedicineAbstract Background Pancreatic ductal adenocarcinoma (PDAC) often infiltrates to the adjacent major vasculatures; however, direct invasion of PDAC to the inferior vena cava (IVC) is uncommon. Case presentation We report our experience with three cases of PDAC directly invading the IVC wall. All three patients underwent pancreatoduodenectomy along with wedge resection of the IVC wall without severe postoperative complications. Histopathological studies revealed tumor infiltration to the adventitia of the IVC. All patients achieved negative surgical margins. One patient was still alive 26 months after surgery without tumor recurrence. Two patients experienced recurrence; one patient experienced liver metastasis but was still alive and in a stable condition without further tumor progression 12 months after surgery. Another patient experienced multiple liver metastasis 10 months after surgery and died 26 months after surgery. Conclusions Pancreatoduodenectomy along with wedge resection of the IVC wall for patients with PDAC directly invading the adventitia of the IVC can be performed safely. Further accumulation of cases is needed to elucidate the prognostic impact of IVC invasion.http://link.springer.com/article/10.1186/s40792-017-0348-5Pancreatic ductal adenocarcinomaInferior vena cavaInvasionResection |
| spellingShingle | Takuya Mizumoto Tadahiro Goto Hirochika Toyama Keitaro Sofue Sadaki Asari Sachio Terai Motofumi Tanaka Masahiro Kido Tetsuo Ajiki Takumi Fukumoto Yonson Ku Pancreatic ductal adenocarcinoma with inferior vena cava invasion: a report of three resected cases Surgical Case Reports Pancreatic ductal adenocarcinoma Inferior vena cava Invasion Resection |
| title | Pancreatic ductal adenocarcinoma with inferior vena cava invasion: a report of three resected cases |
| title_full | Pancreatic ductal adenocarcinoma with inferior vena cava invasion: a report of three resected cases |
| title_fullStr | Pancreatic ductal adenocarcinoma with inferior vena cava invasion: a report of three resected cases |
| title_full_unstemmed | Pancreatic ductal adenocarcinoma with inferior vena cava invasion: a report of three resected cases |
| title_short | Pancreatic ductal adenocarcinoma with inferior vena cava invasion: a report of three resected cases |
| title_sort | pancreatic ductal adenocarcinoma with inferior vena cava invasion a report of three resected cases |
| topic | Pancreatic ductal adenocarcinoma Inferior vena cava Invasion Resection |
| url | http://link.springer.com/article/10.1186/s40792-017-0348-5 |
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