The Effect of Peritoneal Air Exposure on Intestinal Mucosal Barrier
Background. Damage of the intestinal mucosa barrier may result in intestinal bacterial and endotoxin translocation, leading to local and systemic inflammation. The present study was designed to investigate whether peritoneal air exposure induces damage of intestinal mucosal barrier. Methods. Sprague...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2014/674875 |
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| author | Jun Bao Shanjun Tan Wenkui Yu Zhiliang Lin Yi Dong Qiyi Chen Jialiang Shi Kaipeng Duan Xiaowu Bai Lin Xu Jieshou Li Ning Li |
| author_facet | Jun Bao Shanjun Tan Wenkui Yu Zhiliang Lin Yi Dong Qiyi Chen Jialiang Shi Kaipeng Duan Xiaowu Bai Lin Xu Jieshou Li Ning Li |
| author_sort | Jun Bao |
| collection | DOAJ |
| description | Background. Damage of the intestinal mucosa barrier may result in intestinal bacterial and endotoxin translocation, leading to local and systemic inflammation. The present study was designed to investigate whether peritoneal air exposure induces damage of intestinal mucosal barrier. Methods. Sprague-Dawley rats (weighing 210 to 230 g) were randomized into five groups (6/group): a control group, a sham group, and three exposure groups with peritoneal air exposure for 1, 2, and 3 h, respectively. At 24 h after surgery, blood and terminal ileum were sampled. The serum D-lactate levels were determined using an ELISA kit. The intestinal permeability was determined by measuring the intestinal clearance of FITC-dextran (FD4). The histopathological changes in terminal ileum were also assessed. Results. Compared with the controls, peritoneal air exposure caused an increase in both serum D-lactate level and intestinal FD4 clearance, which were proportional to the length of peritoneal air exposure and correlated to Chiu’s scores, indices for intestinal mucosal injury. Edema and inflammatory cells were also observed in mucosa and submucosa of ileum in three exposure groups. Conclusions. Peritoneal air exposure could induce damage to the intestinal mucosal barrier, which is proportional to the time length of peritoneal air exposure. |
| format | Article |
| id | doaj-art-9c744d22b74a4f479b1127c9876ccaa6 |
| institution | OA Journals |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-9c744d22b74a4f479b1127c9876ccaa62025-08-20T02:18:28ZengWileyGastroenterology Research and Practice1687-61211687-630X2014-01-01201410.1155/2014/674875674875The Effect of Peritoneal Air Exposure on Intestinal Mucosal BarrierJun Bao0Shanjun Tan1Wenkui Yu2Zhiliang Lin3Yi Dong4Qiyi Chen5Jialiang Shi6Kaipeng Duan7Xiaowu Bai8Lin Xu9Jieshou Li10Ning Li11Department of General Internal Medicine, Jiangsu Province Official Hospital, Nanjing 210024, ChinaResearch Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, ChinaResearch Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, ChinaResearch Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, ChinaResearch Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, ChinaResearch Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, ChinaResearch Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, ChinaResearch Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, ChinaResearch Institute of General Surgery, Jinling Hospital, Clinical School of Nanjing, Second Military Medical University, Nanjing 210002, ChinaResearch Institute of General Surgery, Jinling Hospital, Clinical School of Nanjing, Second Military Medical University, Nanjing 210002, ChinaResearch Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, ChinaResearch Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, ChinaBackground. Damage of the intestinal mucosa barrier may result in intestinal bacterial and endotoxin translocation, leading to local and systemic inflammation. The present study was designed to investigate whether peritoneal air exposure induces damage of intestinal mucosal barrier. Methods. Sprague-Dawley rats (weighing 210 to 230 g) were randomized into five groups (6/group): a control group, a sham group, and three exposure groups with peritoneal air exposure for 1, 2, and 3 h, respectively. At 24 h after surgery, blood and terminal ileum were sampled. The serum D-lactate levels were determined using an ELISA kit. The intestinal permeability was determined by measuring the intestinal clearance of FITC-dextran (FD4). The histopathological changes in terminal ileum were also assessed. Results. Compared with the controls, peritoneal air exposure caused an increase in both serum D-lactate level and intestinal FD4 clearance, which were proportional to the length of peritoneal air exposure and correlated to Chiu’s scores, indices for intestinal mucosal injury. Edema and inflammatory cells were also observed in mucosa and submucosa of ileum in three exposure groups. Conclusions. Peritoneal air exposure could induce damage to the intestinal mucosal barrier, which is proportional to the time length of peritoneal air exposure.http://dx.doi.org/10.1155/2014/674875 |
| spellingShingle | Jun Bao Shanjun Tan Wenkui Yu Zhiliang Lin Yi Dong Qiyi Chen Jialiang Shi Kaipeng Duan Xiaowu Bai Lin Xu Jieshou Li Ning Li The Effect of Peritoneal Air Exposure on Intestinal Mucosal Barrier Gastroenterology Research and Practice |
| title | The Effect of Peritoneal Air Exposure on Intestinal Mucosal Barrier |
| title_full | The Effect of Peritoneal Air Exposure on Intestinal Mucosal Barrier |
| title_fullStr | The Effect of Peritoneal Air Exposure on Intestinal Mucosal Barrier |
| title_full_unstemmed | The Effect of Peritoneal Air Exposure on Intestinal Mucosal Barrier |
| title_short | The Effect of Peritoneal Air Exposure on Intestinal Mucosal Barrier |
| title_sort | effect of peritoneal air exposure on intestinal mucosal barrier |
| url | http://dx.doi.org/10.1155/2014/674875 |
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