Diagnosing MALT Gastric Lymphoma in Gastroenterologist’s Practice, a Clinical Observation
Aim. A clinical case description to highlight challenges in diagnosing MALT lymphoma presented in infiltrative ulcer-ative lesions.Key points. A 60-yo patient was admitted to the Loginov Moscow Clinical Scientific Centre with epigastric pain and an 18 kg weight loss over past 4 months. A history of...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Gastro LLC
2021-10-01
|
| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| Subjects: | |
| Online Access: | https://www.gastro-j.ru/jour/article/view/521 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823860146536710144 |
|---|---|
| author | E. Ya. Selezneva N. A. Shcherbakova Yu. V. Embutnieks E. V. Bystrovskaya S. G. Khomeriki |
| author_facet | E. Ya. Selezneva N. A. Shcherbakova Yu. V. Embutnieks E. V. Bystrovskaya S. G. Khomeriki |
| author_sort | E. Ya. Selezneva |
| collection | DOAJ |
| description | Aim. A clinical case description to highlight challenges in diagnosing MALT lymphoma presented in infiltrative ulcer-ative lesions.Key points. A 60-yo patient was admitted to the Loginov Moscow Clinical Scientific Centre with epigastric pain and an 18 kg weight loss over past 4 months. A history of repeated outpatient endoscopic examinations revealing subse-quently ulcerative and infiltrative ulcerative gastric lesions of unestablished origin. A complex examination combin-ing oesophagogastroduodenoscopy (OGDS), endosonography (EUS), multislice computed tomography (MSCT), morphological and immunohistochemical (IHC) assays elicited the MALT gastric lymphoma IIE stage involving para-gastric and intraperitoneal lymph nodes. The first treatment stage included line-1 eradication therapy, rabeprazole 20 mg x 2 times a day, amoxicillin 1000 mg x 2 times a day, clarithromycin 500 mg x 2 times a day, bismuth tripotas-sium dicitrate 240 mg x 2 times a day — for 14 days. Accounting for the process prevalence and stage, six courses of R-CHOP polychemotherapy (PCT) were ordered by haematologist.Conclusion. This observation demonstrates a targeted-biopsy endoscopic examination followed by morphological, IHC, EUS (for invasion depth) and MSCT (for process advancement) assays to be decisive in differential diagnosis of ulcerative and infiltrative ulcerative gastric lesions. |
| format | Article |
| id | doaj-art-9c736f30c7424153a5cb21f4f931b6db |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2021-10-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-9c736f30c7424153a5cb21f4f931b6db2025-02-10T16:14:36ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732021-10-01313606710.22416/1382-4376-2021-31-3-60-67430Diagnosing MALT Gastric Lymphoma in Gastroenterologist’s Practice, a Clinical ObservationE. Ya. Selezneva0N. A. Shcherbakova1Yu. V. Embutnieks2E. V. Bystrovskaya3S. G. Khomeriki4Loginov Moscow Clinical Scientific CentreLoginov Moscow Clinical Scientific CentreLoginov Moscow Clinical Scientific CentreLoginov Moscow Clinical Scientific CentreLoginov Moscow Clinical Scientific CentreAim. A clinical case description to highlight challenges in diagnosing MALT lymphoma presented in infiltrative ulcer-ative lesions.Key points. A 60-yo patient was admitted to the Loginov Moscow Clinical Scientific Centre with epigastric pain and an 18 kg weight loss over past 4 months. A history of repeated outpatient endoscopic examinations revealing subse-quently ulcerative and infiltrative ulcerative gastric lesions of unestablished origin. A complex examination combin-ing oesophagogastroduodenoscopy (OGDS), endosonography (EUS), multislice computed tomography (MSCT), morphological and immunohistochemical (IHC) assays elicited the MALT gastric lymphoma IIE stage involving para-gastric and intraperitoneal lymph nodes. The first treatment stage included line-1 eradication therapy, rabeprazole 20 mg x 2 times a day, amoxicillin 1000 mg x 2 times a day, clarithromycin 500 mg x 2 times a day, bismuth tripotas-sium dicitrate 240 mg x 2 times a day — for 14 days. Accounting for the process prevalence and stage, six courses of R-CHOP polychemotherapy (PCT) were ordered by haematologist.Conclusion. This observation demonstrates a targeted-biopsy endoscopic examination followed by morphological, IHC, EUS (for invasion depth) and MSCT (for process advancement) assays to be decisive in differential diagnosis of ulcerative and infiltrative ulcerative gastric lesions.https://www.gastro-j.ru/jour/article/view/521malt gastric lymphomah. pylorieradication therapy conflict of interest: the authors declare no conflict of interest |
| spellingShingle | E. Ya. Selezneva N. A. Shcherbakova Yu. V. Embutnieks E. V. Bystrovskaya S. G. Khomeriki Diagnosing MALT Gastric Lymphoma in Gastroenterologist’s Practice, a Clinical Observation Российский журнал гастроэнтерологии, гепатологии, колопроктологии malt gastric lymphoma h. pylori eradication therapy conflict of interest: the authors declare no conflict of interest |
| title | Diagnosing MALT Gastric Lymphoma in Gastroenterologist’s Practice, a Clinical Observation |
| title_full | Diagnosing MALT Gastric Lymphoma in Gastroenterologist’s Practice, a Clinical Observation |
| title_fullStr | Diagnosing MALT Gastric Lymphoma in Gastroenterologist’s Practice, a Clinical Observation |
| title_full_unstemmed | Diagnosing MALT Gastric Lymphoma in Gastroenterologist’s Practice, a Clinical Observation |
| title_short | Diagnosing MALT Gastric Lymphoma in Gastroenterologist’s Practice, a Clinical Observation |
| title_sort | diagnosing malt gastric lymphoma in gastroenterologist s practice a clinical observation |
| topic | malt gastric lymphoma h. pylori eradication therapy conflict of interest: the authors declare no conflict of interest |
| url | https://www.gastro-j.ru/jour/article/view/521 |
| work_keys_str_mv | AT eyaselezneva diagnosingmaltgastriclymphomaingastroenterologistspracticeaclinicalobservation AT nashcherbakova diagnosingmaltgastriclymphomaingastroenterologistspracticeaclinicalobservation AT yuvembutnieks diagnosingmaltgastriclymphomaingastroenterologistspracticeaclinicalobservation AT evbystrovskaya diagnosingmaltgastriclymphomaingastroenterologistspracticeaclinicalobservation AT sgkhomeriki diagnosingmaltgastriclymphomaingastroenterologistspracticeaclinicalobservation |