Increased Recall of Negative Memories Following Initial Methylphenidate Administration in a 6‐Year‐Old Boy With ADHD: A Case Report

ABSTRACT Attention‐deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder that begins in childhood and can persist into adolescence and adulthood. Stimulants, particularly methylphenidate and amphetamines, are the first‐line treatments for ADHD in children and adolescents. While the...

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Bibliographic Details
Main Authors: Qingqing Xiang, Liling Xu, Yanping Feng, Anhong Ye, Bo Liu, Youguo Tan
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Neuropsychopharmacology Reports
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Online Access:https://doi.org/10.1002/npr2.70026
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Summary:ABSTRACT Attention‐deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder that begins in childhood and can persist into adolescence and adulthood. Stimulants, particularly methylphenidate and amphetamines, are the first‐line treatments for ADHD in children and adolescents. While the potential for stimulants to induce psychosis‐like or mania‐like symptoms in children has been recognized for decades, there have been no reported cases of increased recall of negative memories associated with methylphenidate. Here, we present a rare case in which an initial dose of 18 mg of Methylphenidate Hydrochloride Extended‐Release Tablets led to increased recall of negative life events in a 6‐year‐old child with ADHD. Interestingly, the symptom resolved spontaneously the following day without discontinuing the medication, suggesting that it was an adaptive response rather than a toxic reaction.
ISSN:2574-173X