Lack of activity of HIV-1 integrase strand-transfer inhibitors on recombinase activating gene (RAG) activity at clinically relevant concentrations

Lack of activity of HIV-1 integrase strand-transfer inhibitors on recombinase activating gene (RAG) activity at clinically relevant concentrations

ABSTRACT Human immunodeficiency virus 1 (HIV-1) infection remains a global health concern, with nearly 30 million people on antiretroviral (ARV) treatment. Integrase strand-transfer inhibitors (INSTIs) that block HIV-1 integrase are crucial components of first-line combination ARV therapies recommen...

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Bibliographic Details
Main Authors: Sally Demirdjian, Vincent N. Duong, Jennifer N. Byrum, Arabinda Nayak, Cooper B. McKinney, Jason K. Perry, Christian Callebaut, Karla K. Rodgers, Brie Falkard, Joy Y. Feng
Format: Article
Language:English
Published: American Society for Microbiology 2025-01-01
Series:Microbiology Spectrum
Subjects:
HIV-1
recombinase activating gene
INSTI
integrase
V(D)J recombination
RAG1/RAG2
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02468-24
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