Efficacy of nucleoside analogues for hepatitis B virus-related liver failure: A network meta-analysis

The purpose of this study was to compare the efficacy of nucleoside analogues (NAs) in the treatment of HBV-related liver failure. The data of patients with HBV-related liver failure treated with nucleoside analogues were used to conduct a network meta-analysis. A total of 1660 patients from 12 arti...

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Main Authors: Wu Jian, Yin Fang, Zhou Xinmin
Format: Article
Language:English
Published: Sciendo 2018-03-01
Series:Acta Pharmaceutica
Subjects:
Online Access:https://doi.org/10.2478/acph-2018-0010
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author Wu Jian
Yin Fang
Zhou Xinmin
author_facet Wu Jian
Yin Fang
Zhou Xinmin
author_sort Wu Jian
collection DOAJ
description The purpose of this study was to compare the efficacy of nucleoside analogues (NAs) in the treatment of HBV-related liver failure. The data of patients with HBV-related liver failure treated with nucleoside analogues were used to conduct a network meta-analysis. A total of 1660 patients from 12 articles about the efficacy of lamivudine, entecavir, telbivudine and tenofovir for HBV-related liver failure treatment were recruited in the study. The highest two- and three-month survival rate was recorded for patients using tenofovir. The end-stage liver disease (MELD) score and mortality in patients undergoing tenofovir treatment were the lowest. Patients treated with telbivudine had the highest one-month survival rate. Patients receiving enticavir therapy showed the lowest HBV DNA level. Our results indicate that tenofovir may be the best therapy for the treatment of HBV-related liver failure compared to other nucleoside analogues (including lamivudine, entecavir and telbivudine) and non-NAs treatment.
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spelling doaj-art-9c603c9abf6f41158497d8cc88aa2d712025-02-02T12:01:38ZengSciendoActa Pharmaceutica1846-95582018-03-01681193010.2478/acph-2018-0010acph-2018-0010Efficacy of nucleoside analogues for hepatitis B virus-related liver failure: A network meta-analysisWu Jian0Yin Fang1Zhou Xinmin2Digestion Internal Medicine Department, Xijing Hospital The First Affiliated Hospital of the Fourth Military Medical University Xi’an Shaanxi 710000, ChinaDigestion Internal Medicine Department, Xijing Hospital The First Affiliated Hospital of the Fourth Military Medical University Xi’an Shaanxi 710000, ChinaDigestion Internal Medicine Department, Xijing Hospital The First Affiliated Hospital of the Fourth Military Medical University Xi’an Shaanxi 710000, ChinaThe purpose of this study was to compare the efficacy of nucleoside analogues (NAs) in the treatment of HBV-related liver failure. The data of patients with HBV-related liver failure treated with nucleoside analogues were used to conduct a network meta-analysis. A total of 1660 patients from 12 articles about the efficacy of lamivudine, entecavir, telbivudine and tenofovir for HBV-related liver failure treatment were recruited in the study. The highest two- and three-month survival rate was recorded for patients using tenofovir. The end-stage liver disease (MELD) score and mortality in patients undergoing tenofovir treatment were the lowest. Patients treated with telbivudine had the highest one-month survival rate. Patients receiving enticavir therapy showed the lowest HBV DNA level. Our results indicate that tenofovir may be the best therapy for the treatment of HBV-related liver failure compared to other nucleoside analogues (including lamivudine, entecavir and telbivudine) and non-NAs treatment.https://doi.org/10.2478/acph-2018-0010liver failurehepatitis b virusnucleoside analoguetenofovirnetwork meta-analysis
spellingShingle Wu Jian
Yin Fang
Zhou Xinmin
Efficacy of nucleoside analogues for hepatitis B virus-related liver failure: A network meta-analysis
Acta Pharmaceutica
liver failure
hepatitis b virus
nucleoside analogue
tenofovir
network meta-analysis
title Efficacy of nucleoside analogues for hepatitis B virus-related liver failure: A network meta-analysis
title_full Efficacy of nucleoside analogues for hepatitis B virus-related liver failure: A network meta-analysis
title_fullStr Efficacy of nucleoside analogues for hepatitis B virus-related liver failure: A network meta-analysis
title_full_unstemmed Efficacy of nucleoside analogues for hepatitis B virus-related liver failure: A network meta-analysis
title_short Efficacy of nucleoside analogues for hepatitis B virus-related liver failure: A network meta-analysis
title_sort efficacy of nucleoside analogues for hepatitis b virus related liver failure a network meta analysis
topic liver failure
hepatitis b virus
nucleoside analogue
tenofovir
network meta-analysis
url https://doi.org/10.2478/acph-2018-0010
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AT zhouxinmin efficacyofnucleosideanaloguesforhepatitisbvirusrelatedliverfailureanetworkmetaanalysis