Type 2 diabetes, gut microbiome, and systems biology: A novel perspective for a new era
The association between the physio-pathological variables of type 2 diabetes (T2D) and gut microbiota composition suggests a new avenue to track the disease and improve the outcomes of pharmacological and non-pharmacological treatments. This enterprise requires new strategies to elucidate the metabo...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | Gut Microbes |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2022.2111952 |
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| author | Yoscelina Estrella Martínez-López Diego A. Esquivel-Hernández Jean Paul Sánchez-Castañeda Daniel Neri-Rosario Rodolfo Guardado-Mendoza Osbaldo Resendis-Antonio |
| author_facet | Yoscelina Estrella Martínez-López Diego A. Esquivel-Hernández Jean Paul Sánchez-Castañeda Daniel Neri-Rosario Rodolfo Guardado-Mendoza Osbaldo Resendis-Antonio |
| author_sort | Yoscelina Estrella Martínez-López |
| collection | DOAJ |
| description | The association between the physio-pathological variables of type 2 diabetes (T2D) and gut microbiota composition suggests a new avenue to track the disease and improve the outcomes of pharmacological and non-pharmacological treatments. This enterprise requires new strategies to elucidate the metabolic disturbances occurring in the gut microbiome as the disease progresses. To this end, physiological knowledge and systems biology pave the way for characterizing microbiota and identifying strategies in a move toward healthy compositions. Here, we dissect the recent associations between gut microbiota and T2D. In addition, we discuss recent advances in how drugs, diet, and exercise modulate the microbiome to favor healthy stages. Finally, we present computational approaches for disentangling the metabolic activity underlying host-microbiota codependence. Altogether, we envision that the combination of physiology and computational modeling of microbiota metabolism will drive us to optimize the diagnosis and treatment of T2D patients in a personalized way. |
| format | Article |
| id | doaj-art-9c5d4bf9a0df4e7f887f9b16fecbc7d8 |
| institution | DOAJ |
| issn | 1949-0976 1949-0984 |
| language | English |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj-art-9c5d4bf9a0df4e7f887f9b16fecbc7d82025-08-20T03:05:24ZengTaylor & Francis GroupGut Microbes1949-09761949-09842022-12-0114110.1080/19490976.2022.2111952Type 2 diabetes, gut microbiome, and systems biology: A novel perspective for a new eraYoscelina Estrella Martínez-López0Diego A. Esquivel-Hernández1Jean Paul Sánchez-Castañeda2Daniel Neri-Rosario3Rodolfo Guardado-Mendoza4Osbaldo Resendis-Antonio5Human Systems Biology Laboratory. Instituto Nacional de Medicina Genómica (INMEGEN). México City, MéxicoHuman Systems Biology Laboratory. Instituto Nacional de Medicina Genómica (INMEGEN). México City, MéxicoHuman Systems Biology Laboratory. Instituto Nacional de Medicina Genómica (INMEGEN). México City, MéxicoHuman Systems Biology Laboratory. Instituto Nacional de Medicina Genómica (INMEGEN). México City, MéxicoMetabolic Research Laboratory, Department of Medicine and Nutrition. University of Guanajuato. León, Guanajuato, MéxicoHuman Systems Biology Laboratory. Instituto Nacional de Medicina Genómica (INMEGEN). México City, MéxicoThe association between the physio-pathological variables of type 2 diabetes (T2D) and gut microbiota composition suggests a new avenue to track the disease and improve the outcomes of pharmacological and non-pharmacological treatments. This enterprise requires new strategies to elucidate the metabolic disturbances occurring in the gut microbiome as the disease progresses. To this end, physiological knowledge and systems biology pave the way for characterizing microbiota and identifying strategies in a move toward healthy compositions. Here, we dissect the recent associations between gut microbiota and T2D. In addition, we discuss recent advances in how drugs, diet, and exercise modulate the microbiome to favor healthy stages. Finally, we present computational approaches for disentangling the metabolic activity underlying host-microbiota codependence. Altogether, we envision that the combination of physiology and computational modeling of microbiota metabolism will drive us to optimize the diagnosis and treatment of T2D patients in a personalized way.https://www.tandfonline.com/doi/10.1080/19490976.2022.2111952Gut microbiometype 2 diabetesdietphysical activityanti-diabetic drugshigh-throughput data |
| spellingShingle | Yoscelina Estrella Martínez-López Diego A. Esquivel-Hernández Jean Paul Sánchez-Castañeda Daniel Neri-Rosario Rodolfo Guardado-Mendoza Osbaldo Resendis-Antonio Type 2 diabetes, gut microbiome, and systems biology: A novel perspective for a new era Gut Microbes Gut microbiome type 2 diabetes diet physical activity anti-diabetic drugs high-throughput data |
| title | Type 2 diabetes, gut microbiome, and systems biology: A novel perspective for a new era |
| title_full | Type 2 diabetes, gut microbiome, and systems biology: A novel perspective for a new era |
| title_fullStr | Type 2 diabetes, gut microbiome, and systems biology: A novel perspective for a new era |
| title_full_unstemmed | Type 2 diabetes, gut microbiome, and systems biology: A novel perspective for a new era |
| title_short | Type 2 diabetes, gut microbiome, and systems biology: A novel perspective for a new era |
| title_sort | type 2 diabetes gut microbiome and systems biology a novel perspective for a new era |
| topic | Gut microbiome type 2 diabetes diet physical activity anti-diabetic drugs high-throughput data |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2022.2111952 |
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