Metabolomic data on molecular weight fractions of the cultivated fruiting body of Ophiocordyceps sinensis and their pharmacological effects on airway tissuesMendeley Data
Ophiocordyceps sinensis is a medicinal mushroom that has been traditionally used for promoting respiratory health and addressing diverse therapeutic needs.The data in this article provides insights into the metabolic profile of the cultivated fruiting body of Ophiocordyceps sinensis (xOs™) across di...
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Elsevier
2025-10-01
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352340925006286 |
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| author | Han-Ni Booi Neng-Yao Goh Mei-Kee Lee Chyan-Leong Ng Szu-Ting Ng Chon-Seng Tan Kuan-Hon Lim Richard Roberts Shin-Yee Fung Kang-Nee Ting |
| author_facet | Han-Ni Booi Neng-Yao Goh Mei-Kee Lee Chyan-Leong Ng Szu-Ting Ng Chon-Seng Tan Kuan-Hon Lim Richard Roberts Shin-Yee Fung Kang-Nee Ting |
| author_sort | Han-Ni Booi |
| collection | DOAJ |
| description | Ophiocordyceps sinensis is a medicinal mushroom that has been traditionally used for promoting respiratory health and addressing diverse therapeutic needs.The data in this article provides insights into the metabolic profile of the cultivated fruiting body of Ophiocordyceps sinensis (xOs™) across different molecular weight (MW) fractions. The cold-water extract obtained from xOs™ was fractionated by MW into high, medium and low MW fractions using size-exclusion chromatography. The metabolic profile of each fraction was analysed through liquid chromatography-mass spectrometry. The identification of metabolites in xOs™ was validated by analysing the mass spectra of both precursor (MS) and daughter ions (MS2) with those documented in the mass spectrometry reference libraries. Additionally, the role of each metabolite was hypothesized based on existing literature to provide scientific rationale for the traditional applications of xOs™.Further investigations into the fractions of xOs™ were conducted using the organ bath approach, in which the airway relaxant effects of each fraction on isolated airway tissues from adult male Sprague-Dawley rats were examined. This information could shed light on the bioactivity of different xOs™ fractions in relaxing airway smooth muscles. Taken together, the metabolomics and pharmacological dataset of xOs™ presented in this study may serve as a reference to facilitate comparative metabolomic analyses involving Ophiocordyceps sinensis and also to support targeted isolation of bioactive components in future works. |
| format | Article |
| id | doaj-art-9c5c34af8fa74ee0a7ae4e5c27441a5a |
| institution | Kabale University |
| issn | 2352-3409 |
| language | English |
| publishDate | 2025-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Data in Brief |
| spelling | doaj-art-9c5c34af8fa74ee0a7ae4e5c27441a5a2025-08-20T03:31:37ZengElsevierData in Brief2352-34092025-10-016211190410.1016/j.dib.2025.111904Metabolomic data on molecular weight fractions of the cultivated fruiting body of Ophiocordyceps sinensis and their pharmacological effects on airway tissuesMendeley DataHan-Ni Booi0Neng-Yao Goh1Mei-Kee Lee2Chyan-Leong Ng3Szu-Ting Ng4Chon-Seng Tan5Kuan-Hon Lim6Richard Roberts7Shin-Yee Fung8Kang-Nee Ting9School of Pharmacy, University of Nottingham Malaysia, Semenyih, Selangor, MalaysiaMedicinal Mushroom Research Group, Department of Molecular Medicine, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, MalaysiaSchool of Pharmacy, University of Nottingham Malaysia, Semenyih, Selangor, MalaysiaInstitute of Systems Biology, Universiti Kebangsaan Malaysia, Bangi, Selangor, MalaysiaLiGNO Biotech Sdn. Bhd., Balakong Jaya, Selangor, MalaysiaLiGNO Biotech Sdn. Bhd., Balakong Jaya, Selangor, MalaysiaSchool of Pharmacy, University of Nottingham Malaysia, Semenyih, Selangor, MalaysiaSchool of Life Sciences, University of Nottingham Medical School, Queen’s Medical Centre, Nottingham, United KingdomMedicinal Mushroom Research Group, Department of Molecular Medicine, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, MalaysiaSchool of Pharmacy, University of Nottingham Malaysia, Semenyih, Selangor, Malaysia; Corresponding author. School of Pharmacy, University of Nottingham Malaysia, Jalan Broga 43500 Semenyih, Malaysia.Ophiocordyceps sinensis is a medicinal mushroom that has been traditionally used for promoting respiratory health and addressing diverse therapeutic needs.The data in this article provides insights into the metabolic profile of the cultivated fruiting body of Ophiocordyceps sinensis (xOs™) across different molecular weight (MW) fractions. The cold-water extract obtained from xOs™ was fractionated by MW into high, medium and low MW fractions using size-exclusion chromatography. The metabolic profile of each fraction was analysed through liquid chromatography-mass spectrometry. The identification of metabolites in xOs™ was validated by analysing the mass spectra of both precursor (MS) and daughter ions (MS2) with those documented in the mass spectrometry reference libraries. Additionally, the role of each metabolite was hypothesized based on existing literature to provide scientific rationale for the traditional applications of xOs™.Further investigations into the fractions of xOs™ were conducted using the organ bath approach, in which the airway relaxant effects of each fraction on isolated airway tissues from adult male Sprague-Dawley rats were examined. This information could shed light on the bioactivity of different xOs™ fractions in relaxing airway smooth muscles. Taken together, the metabolomics and pharmacological dataset of xOs™ presented in this study may serve as a reference to facilitate comparative metabolomic analyses involving Ophiocordyceps sinensis and also to support targeted isolation of bioactive components in future works.http://www.sciencedirect.com/science/article/pii/S2352340925006286Medicinal mushroomAirway relaxationOrgan bathFractionationLiquid chromatography-mass spectrometry |
| spellingShingle | Han-Ni Booi Neng-Yao Goh Mei-Kee Lee Chyan-Leong Ng Szu-Ting Ng Chon-Seng Tan Kuan-Hon Lim Richard Roberts Shin-Yee Fung Kang-Nee Ting Metabolomic data on molecular weight fractions of the cultivated fruiting body of Ophiocordyceps sinensis and their pharmacological effects on airway tissuesMendeley Data Data in Brief Medicinal mushroom Airway relaxation Organ bath Fractionation Liquid chromatography-mass spectrometry |
| title | Metabolomic data on molecular weight fractions of the cultivated fruiting body of Ophiocordyceps sinensis and their pharmacological effects on airway tissuesMendeley Data |
| title_full | Metabolomic data on molecular weight fractions of the cultivated fruiting body of Ophiocordyceps sinensis and their pharmacological effects on airway tissuesMendeley Data |
| title_fullStr | Metabolomic data on molecular weight fractions of the cultivated fruiting body of Ophiocordyceps sinensis and their pharmacological effects on airway tissuesMendeley Data |
| title_full_unstemmed | Metabolomic data on molecular weight fractions of the cultivated fruiting body of Ophiocordyceps sinensis and their pharmacological effects on airway tissuesMendeley Data |
| title_short | Metabolomic data on molecular weight fractions of the cultivated fruiting body of Ophiocordyceps sinensis and their pharmacological effects on airway tissuesMendeley Data |
| title_sort | metabolomic data on molecular weight fractions of the cultivated fruiting body of ophiocordyceps sinensis and their pharmacological effects on airway tissuesmendeley data |
| topic | Medicinal mushroom Airway relaxation Organ bath Fractionation Liquid chromatography-mass spectrometry |
| url | http://www.sciencedirect.com/science/article/pii/S2352340925006286 |
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