Occult hepatitis B in Egyptian thalassemic children
Introduction: Thalassemia is hereditary anemia which requires lifelong transfusion as treatment, and hepatitis viral infection is one of the risks of repeated transfusions. Hepatitis B outbreaks in health-care settings are still a serious public health concern worldwide. Blood samples negative for...
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| Format: | Article |
| Language: | English |
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The Journal of Infection in Developing Countries
2011-07-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/1706 |
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| author | Olfat Shaker Amal Ahmed Inas abdel Satar Hamza El Ahl Wafaa Shousha Wahid Doss |
| author_facet | Olfat Shaker Amal Ahmed Inas abdel Satar Hamza El Ahl Wafaa Shousha Wahid Doss |
| author_sort | Olfat Shaker |
| collection | DOAJ |
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Introduction: Thalassemia is hereditary anemia which requires lifelong transfusion as treatment, and hepatitis viral infection is one of the risks of repeated transfusions. Hepatitis B outbreaks in health-care settings are still a serious public health concern worldwide. Blood samples negative for HBsAg but positive for HBV-DNA, with or without the presence of HBV antibodies, are classified as "occult" HBV infection (OBI). This study investigated the prevalence of occult HBV infection in Egyptian thalassemic children.
Methodology: Eighty patients admitted to the Faculty of Medicine, Cairo University Hospital, were involved in this prospective study. Strict inclusion criteria were set to nullify the effect of confounding variables and further minimize selection bias. The following laboratory investigations were performed: complete blood count (CBC); serum AST and ALT; albumin; bilirubin; HBsAg; HBeAg; HBcAb; HCV-RNA; and HBV-DNA.
Results: All our patients had no clinical manifestation suggestive of hepatitis. Molecular biology studies revealed positivity for HCV and HBV at 25% and 32.5% respectively.
Conclusion: The estimated risk of acquiring hepatitis B and C infection in children receiving multiple blood transfusions is surprisingly high. Moreover, occult hepatitis B infection is a considerably risk.
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| format | Article |
| id | doaj-art-9c5b60de98df4ad4990efe600c0d4316 |
| institution | OA Journals |
| issn | 1972-2680 |
| language | English |
| publishDate | 2011-07-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-9c5b60de98df4ad4990efe600c0d43162025-08-20T02:16:18ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802011-07-0160410.3855/jidc.1706Occult hepatitis B in Egyptian thalassemic childrenOlfat Shaker0Amal Ahmed1Inas abdel Satar2Hamza El Ahl3Wafaa Shousha4Wahid Doss5Faculty of Medicine, Cairo University, Cairo, EgyptNational Hepatology and Tropical Medicine Institute, Cairo, EgyptFaculty of Medicine, Cairo University, Cairo, EgyptTabarak Children’s Hospital, Cairo, EgyptFaculty of Science, Helwan University, Helwan, EgyptNational Hepatology and Tropical Medicine Institute, Cairo, Egypt Introduction: Thalassemia is hereditary anemia which requires lifelong transfusion as treatment, and hepatitis viral infection is one of the risks of repeated transfusions. Hepatitis B outbreaks in health-care settings are still a serious public health concern worldwide. Blood samples negative for HBsAg but positive for HBV-DNA, with or without the presence of HBV antibodies, are classified as "occult" HBV infection (OBI). This study investigated the prevalence of occult HBV infection in Egyptian thalassemic children. Methodology: Eighty patients admitted to the Faculty of Medicine, Cairo University Hospital, were involved in this prospective study. Strict inclusion criteria were set to nullify the effect of confounding variables and further minimize selection bias. The following laboratory investigations were performed: complete blood count (CBC); serum AST and ALT; albumin; bilirubin; HBsAg; HBeAg; HBcAb; HCV-RNA; and HBV-DNA. Results: All our patients had no clinical manifestation suggestive of hepatitis. Molecular biology studies revealed positivity for HCV and HBV at 25% and 32.5% respectively. Conclusion: The estimated risk of acquiring hepatitis B and C infection in children receiving multiple blood transfusions is surprisingly high. Moreover, occult hepatitis B infection is a considerably risk. https://jidc.org/index.php/journal/article/view/1706occult HBVhepatitis C virusDNAthalassemiapediatrics |
| spellingShingle | Olfat Shaker Amal Ahmed Inas abdel Satar Hamza El Ahl Wafaa Shousha Wahid Doss Occult hepatitis B in Egyptian thalassemic children Journal of Infection in Developing Countries occult HBV hepatitis C virus DNA thalassemia pediatrics |
| title | Occult hepatitis B in Egyptian thalassemic children |
| title_full | Occult hepatitis B in Egyptian thalassemic children |
| title_fullStr | Occult hepatitis B in Egyptian thalassemic children |
| title_full_unstemmed | Occult hepatitis B in Egyptian thalassemic children |
| title_short | Occult hepatitis B in Egyptian thalassemic children |
| title_sort | occult hepatitis b in egyptian thalassemic children |
| topic | occult HBV hepatitis C virus DNA thalassemia pediatrics |
| url | https://jidc.org/index.php/journal/article/view/1706 |
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