Sex-specific association between atherogenic index of plasma and risk of newly diagnosed abdominal aortic aneurysm: a large population-based cohort study
Abstract Objectives Atherosclerosis of aortic wall has been suggested as a key pathological feature of abdominal aortic aneurysm (AAA). We conducted a first-ever prospective cohort study aiming at assessing the sex-specific association between atherogenic index of plasma (AIP) and risk of newly diag...
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2025-05-01
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| Series: | European Journal of Medical Research |
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| Online Access: | https://doi.org/10.1186/s40001-025-02586-4 |
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| author | Peng Qiu Hongbin Guo Chao Zhu Yijun Liu Jiazhen Zheng Hongji Pu Xinwu Lu Qun Huang Guang Liu Kaichuang Ye Zhen Zhou |
| author_facet | Peng Qiu Hongbin Guo Chao Zhu Yijun Liu Jiazhen Zheng Hongji Pu Xinwu Lu Qun Huang Guang Liu Kaichuang Ye Zhen Zhou |
| author_sort | Peng Qiu |
| collection | DOAJ |
| description | Abstract Objectives Atherosclerosis of aortic wall has been suggested as a key pathological feature of abdominal aortic aneurysm (AAA). We conducted a first-ever prospective cohort study aiming at assessing the sex-specific association between atherogenic index of plasma (AIP) and risk of newly diagnosed AAA. Methods This study included 193,013 male and 226,785 female participants from the UK Biobank. AIP was calculated as a ratio of logarithmically transformed triglycerides to high-density lipoprotein-cholesterol. The outcome of interest was new AAA, identified by ICD-10 and OPCS-4 code, or by AAA-related death. All analyses were sex-stratified: Multivariable Cox proportional-hazard models were employed to assess the association between baseline AIP and AAA risk. Harrell’s c index was estimated to assess the value of AIP added to the discrimination of AAA prediction model. Results Over an average follow-up of 15.3 years, 1931 (1.00%) new AAA cases were recorded in males and 424 (0.19%) in females. In the fully adjusted models, compared with the bottom AIP quintile, HRs (95% CI) of newly diagnosed AAA was 1.67 (1.41, 1.96) in males and 1.75 (1.22, 2.52) in females within the top quintile. Subgroup analysis found smoking status significantly modified the association in females, with association existing only in female ever-smokers. Adding AIP into prediction model comprising age, smoking, and CVD history significantly improved the discrimination in males and male high-risk subgroups and in female ever-smokers (p < 0.05). Conclusions This study highlights the potential of AIP as a biomarker for AAA and its utility in identifying high-risk individuals qualified for AAA screening. |
| format | Article |
| id | doaj-art-9c586caa5e08499589845bcf24cd13cb |
| institution | Kabale University |
| issn | 2047-783X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj-art-9c586caa5e08499589845bcf24cd13cb2025-08-20T03:53:21ZengBMCEuropean Journal of Medical Research2047-783X2025-05-0130111210.1186/s40001-025-02586-4Sex-specific association between atherogenic index of plasma and risk of newly diagnosed abdominal aortic aneurysm: a large population-based cohort studyPeng Qiu0Hongbin Guo1Chao Zhu2Yijun Liu3Jiazhen Zheng4Hongji Pu5Xinwu Lu6Qun Huang7Guang Liu8Kaichuang Ye9Zhen Zhou10Department of Vascular Surgery, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of MedicineDepartment of Vascular Surgery, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of MedicineDepartment of Neuroscience, School of Translational Medicine, Monash UniversityDepartment of Vascular Surgery, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of MedicineBioscience and Biomedical Engineering Thrust, Systems Hub, The Hong Kong University of Science and Technology (Guangzhou)Department of Vascular Surgery, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of MedicineDepartment of Vascular Surgery, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of MedicineDepartment of Vascular Surgery, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of MedicineDepartment of Vascular Surgery, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of MedicineDepartment of Vascular Surgery, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of MedicineSchool of Public Health and Preventive Medicine, Monash UniversityAbstract Objectives Atherosclerosis of aortic wall has been suggested as a key pathological feature of abdominal aortic aneurysm (AAA). We conducted a first-ever prospective cohort study aiming at assessing the sex-specific association between atherogenic index of plasma (AIP) and risk of newly diagnosed AAA. Methods This study included 193,013 male and 226,785 female participants from the UK Biobank. AIP was calculated as a ratio of logarithmically transformed triglycerides to high-density lipoprotein-cholesterol. The outcome of interest was new AAA, identified by ICD-10 and OPCS-4 code, or by AAA-related death. All analyses were sex-stratified: Multivariable Cox proportional-hazard models were employed to assess the association between baseline AIP and AAA risk. Harrell’s c index was estimated to assess the value of AIP added to the discrimination of AAA prediction model. Results Over an average follow-up of 15.3 years, 1931 (1.00%) new AAA cases were recorded in males and 424 (0.19%) in females. In the fully adjusted models, compared with the bottom AIP quintile, HRs (95% CI) of newly diagnosed AAA was 1.67 (1.41, 1.96) in males and 1.75 (1.22, 2.52) in females within the top quintile. Subgroup analysis found smoking status significantly modified the association in females, with association existing only in female ever-smokers. Adding AIP into prediction model comprising age, smoking, and CVD history significantly improved the discrimination in males and male high-risk subgroups and in female ever-smokers (p < 0.05). Conclusions This study highlights the potential of AIP as a biomarker for AAA and its utility in identifying high-risk individuals qualified for AAA screening.https://doi.org/10.1186/s40001-025-02586-4Atherogenic index of plasmaAbdominal aortic aneurysmAtherosclerosisSexRisk factor |
| spellingShingle | Peng Qiu Hongbin Guo Chao Zhu Yijun Liu Jiazhen Zheng Hongji Pu Xinwu Lu Qun Huang Guang Liu Kaichuang Ye Zhen Zhou Sex-specific association between atherogenic index of plasma and risk of newly diagnosed abdominal aortic aneurysm: a large population-based cohort study European Journal of Medical Research Atherogenic index of plasma Abdominal aortic aneurysm Atherosclerosis Sex Risk factor |
| title | Sex-specific association between atherogenic index of plasma and risk of newly diagnosed abdominal aortic aneurysm: a large population-based cohort study |
| title_full | Sex-specific association between atherogenic index of plasma and risk of newly diagnosed abdominal aortic aneurysm: a large population-based cohort study |
| title_fullStr | Sex-specific association between atherogenic index of plasma and risk of newly diagnosed abdominal aortic aneurysm: a large population-based cohort study |
| title_full_unstemmed | Sex-specific association between atherogenic index of plasma and risk of newly diagnosed abdominal aortic aneurysm: a large population-based cohort study |
| title_short | Sex-specific association between atherogenic index of plasma and risk of newly diagnosed abdominal aortic aneurysm: a large population-based cohort study |
| title_sort | sex specific association between atherogenic index of plasma and risk of newly diagnosed abdominal aortic aneurysm a large population based cohort study |
| topic | Atherogenic index of plasma Abdominal aortic aneurysm Atherosclerosis Sex Risk factor |
| url | https://doi.org/10.1186/s40001-025-02586-4 |
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