Design and Implementation of a Dashboard for Drug Interactions Mediated by Cytochromes Using a Health Care Data Warehouse in a University Hospital Center: Development Study
Abstract BackgroundThe enzymatic system of cytochrome P450 (CYP450 ObjectiveThis study aimed to develop a drug interaction dashboard for Cytochrome-mediated drug interactions (DIDC) using a health care data warehouse to display results that are easily readable and...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JMIR Publications
2024-11-01
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| Series: | JMIR Medical Informatics |
| Online Access: | https://medinform.jmir.org/2024/1/e57705 |
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| Summary: | Abstract
BackgroundThe enzymatic system of cytochrome P450 (CYP450
ObjectiveThis study aimed to develop a drug interaction dashboard for Cytochrome-mediated drug interactions (DIDC) using a health care data warehouse to display results that are easily readable and interpretable by clinical experts.
MethodsThe initial step involved defining requirements with expert pharmacologists. An existing model of interactions involving the (CYP450
ResultsThe development of the DIDC was successfully completed. It automatically compiled cytochrome-mediated DIs in a comprehensive table and provided a dedicated dashboard for each potential DI. The most frequent interaction involved paracetamol and carbamazepine with CYP450 3A4CYP3A5
ConclusionsAt our hospital, measurements of molecules that could have altered concentrations due to cytochrome-mediated DIs are not systematic. These DIs can lead to serious clinical consequences. The purpose of this DIDC is to provide an overall view and raise awareness among prescribers about the importance of measuring concentrations of specific drugs and metabolites. Ultimately, the tool could lead to an individualized approach and become a prescription support tool if integrated into prescription assistance software. |
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| ISSN: | 2291-9694 |