Small-Field Measurements of 3D Polymer Gel Dosimeters through Optical Computed Tomography.
With advances in therapeutic instruments and techniques, three-dimensional dose delivery has been widely used in radiotherapy. The verification of dose distribution in a small field becomes critical because of the obvious dose gradient within the field. The study investigates the dose distributions...
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| Format: | Article |
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0151300&type=printable |
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| author | Tian-Yu Shih Jay Wu Cheng-Ting Shih Yao-Ting Lee Shin-Hua Wu Chun-Hsu Yao Bor-Tsung Hsieh |
| author_facet | Tian-Yu Shih Jay Wu Cheng-Ting Shih Yao-Ting Lee Shin-Hua Wu Chun-Hsu Yao Bor-Tsung Hsieh |
| author_sort | Tian-Yu Shih |
| collection | DOAJ |
| description | With advances in therapeutic instruments and techniques, three-dimensional dose delivery has been widely used in radiotherapy. The verification of dose distribution in a small field becomes critical because of the obvious dose gradient within the field. The study investigates the dose distributions of various field sizes by using NIPAM polymer gel dosimeter. The dosimeter consists of 5% gelatin, 5% monomers, 3% cross linkers, and 5 mM THPC. After irradiation, a 24 to 96 hour delay was applied, and the gel dosimeters were read by a cone beam optical computed tomography (optical CT) scanner. The dose distributions measured by the NIPAM gel dosimeter were compared to the outputs of the treatment planning system using gamma evaluation. For the criteria of 3%/3 mm, the pass rates for 5 × 5, 3 × 3, 2 × 2, 1 × 1, and 0.5 × 0.5 cm2 were as high as 91.7%, 90.7%, 88.2%, 74.8%, and 37.3%, respectively. For the criteria of 5%/5 mm, the gamma pass rates of the 5 × 5, 3 × 3, and 2 × 2 cm2 fields were over 99%. The NIPAM gel dosimeter provides high chemical stability. With cone-beam optical CT readouts, the NIPAM polymer gel dosimeter has potential for clinical dose verification of small-field irradiation. |
| format | Article |
| id | doaj-art-9c4ff1df2f7443bd92c55ab1c43f7389 |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-9c4ff1df2f7443bd92c55ab1c43f73892025-08-20T03:11:13ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01113e015130010.1371/journal.pone.0151300Small-Field Measurements of 3D Polymer Gel Dosimeters through Optical Computed Tomography.Tian-Yu ShihJay WuCheng-Ting ShihYao-Ting LeeShin-Hua WuChun-Hsu YaoBor-Tsung HsiehWith advances in therapeutic instruments and techniques, three-dimensional dose delivery has been widely used in radiotherapy. The verification of dose distribution in a small field becomes critical because of the obvious dose gradient within the field. The study investigates the dose distributions of various field sizes by using NIPAM polymer gel dosimeter. The dosimeter consists of 5% gelatin, 5% monomers, 3% cross linkers, and 5 mM THPC. After irradiation, a 24 to 96 hour delay was applied, and the gel dosimeters were read by a cone beam optical computed tomography (optical CT) scanner. The dose distributions measured by the NIPAM gel dosimeter were compared to the outputs of the treatment planning system using gamma evaluation. For the criteria of 3%/3 mm, the pass rates for 5 × 5, 3 × 3, 2 × 2, 1 × 1, and 0.5 × 0.5 cm2 were as high as 91.7%, 90.7%, 88.2%, 74.8%, and 37.3%, respectively. For the criteria of 5%/5 mm, the gamma pass rates of the 5 × 5, 3 × 3, and 2 × 2 cm2 fields were over 99%. The NIPAM gel dosimeter provides high chemical stability. With cone-beam optical CT readouts, the NIPAM polymer gel dosimeter has potential for clinical dose verification of small-field irradiation.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0151300&type=printable |
| spellingShingle | Tian-Yu Shih Jay Wu Cheng-Ting Shih Yao-Ting Lee Shin-Hua Wu Chun-Hsu Yao Bor-Tsung Hsieh Small-Field Measurements of 3D Polymer Gel Dosimeters through Optical Computed Tomography. PLoS ONE |
| title | Small-Field Measurements of 3D Polymer Gel Dosimeters through Optical Computed Tomography. |
| title_full | Small-Field Measurements of 3D Polymer Gel Dosimeters through Optical Computed Tomography. |
| title_fullStr | Small-Field Measurements of 3D Polymer Gel Dosimeters through Optical Computed Tomography. |
| title_full_unstemmed | Small-Field Measurements of 3D Polymer Gel Dosimeters through Optical Computed Tomography. |
| title_short | Small-Field Measurements of 3D Polymer Gel Dosimeters through Optical Computed Tomography. |
| title_sort | small field measurements of 3d polymer gel dosimeters through optical computed tomography |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0151300&type=printable |
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