An in vitro study of the impact of lead on dedifferentiation of mouse vascular smooth muscle cells

An in vitro study of the impact of lead on dedifferentiation of mouse vascular smooth muscle cells

ObjectiveTo explore the role of lead exposure in the phenotypic transformation of vascular smooth muscle cells (VSMC), and to provide new insights for the mechanism of lead impact on vascular lesions.MethodsMouse aortic smooth muscle cells (MOVAS) were divided into a control group (0 μmol·L-1), low...

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Bibliographic Details
Main Authors: HONG Jiaying, LIU Suhui, LIANG Wenxi, NONG Qiying, HUANG Yongshun
Format: Article
Language:zho
Published: Shanghai Preventive Medicine Association 2025-04-01
Series:Shanghai yufang yixue
Subjects:
lead
vascular smooth muscle cell
phenotypic transformation
smooth muscle actin α
osteopontin
matrix metalloproteinase
in vitro study
Online Access:http://www.sjpm.org.cn/article/doi/10.19428/j.cnki.sjpm.2025.24753
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