Superior Diagnostic Efficacy of N‐Terminal Propeptide of Type III Collagen and Golgi Protein 73 for Detection of Fibrosis in Chronic Hepatitis B Patients
ABSTRACT Significant liver fibrosis is an indication for antiviral therapy in chronic hepatitis B (CHB). Using liver histology assessed by Scheuer system, we evaluated the diagnostic performance of PRO‐C3, GP73, and their combination for the presence of liver fibrosis, and compared them with FIB‐4,...
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Wiley
2025-06-01
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| Online Access: | https://doi.org/10.1002/mco2.70236 |
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| author | Qianqian Chen Ming‐Hua Zheng Li Zhu Fajuan Rui Wenjing Ni Yali Xiong Xinyu Hu Rahma Issa Yixuan Zhu Leyao Jia Scott Barnett Shengxia Yin Chuanwu Zhu Chao Wu Mindie H. Nguyen Jie Li |
| author_facet | Qianqian Chen Ming‐Hua Zheng Li Zhu Fajuan Rui Wenjing Ni Yali Xiong Xinyu Hu Rahma Issa Yixuan Zhu Leyao Jia Scott Barnett Shengxia Yin Chuanwu Zhu Chao Wu Mindie H. Nguyen Jie Li |
| author_sort | Qianqian Chen |
| collection | DOAJ |
| description | ABSTRACT Significant liver fibrosis is an indication for antiviral therapy in chronic hepatitis B (CHB). Using liver histology assessed by Scheuer system, we evaluated the diagnostic performance of PRO‐C3, GP73, and their combination for the presence of liver fibrosis, and compared them with FIB‐4, APRI, Agile 3+, FAST, and LSM in treatment‐naïve CHB patients from two centers. The study included 324 patients, of whom 167 had S2–4 (significant fibrosis) and 83 had S3–4 (advanced fibrosis). PRO‐C3 levels were higher in those with S2–4 and S3–4 compared with S0–1 and S0–2 (both p < 0.001), with similar findings for GP73. PRO‐C3 and GP73 were independently associated with S2–4 and S3–4 in multivariable analyses. The area under the curves (AUCs) of PRO‐C3 for S2–4 and S3–4 were 0.81 and 0.80, respectively, and exceeded those of GP73 (0.75 and 0.73). The combination of PRO‐C3 and GP73 also had significantly higher AUCs for both S2–4 (0.84 vs. 0.64) and S3–4 (0.80 vs. 0.65) as compared with FIB‐4, with similar findings for APRI, GP73, LSM, FAST, and Agile 3+ for S2–4. In conclusion, PRO‐C3 alone or in combination with GP73 is highly predictive for detecting significant liver fibrosis among CHB patients. |
| format | Article |
| id | doaj-art-9c4f058c4ebf4cb19db02e512b4ab355 |
| institution | DOAJ |
| issn | 2688-2663 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley |
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| series | MedComm |
| spelling | doaj-art-9c4f058c4ebf4cb19db02e512b4ab3552025-08-20T02:56:34ZengWileyMedComm2688-26632025-06-0166n/an/a10.1002/mco2.70236Superior Diagnostic Efficacy of N‐Terminal Propeptide of Type III Collagen and Golgi Protein 73 for Detection of Fibrosis in Chronic Hepatitis B PatientsQianqian Chen0Ming‐Hua Zheng1Li Zhu2Fajuan Rui3Wenjing Ni4Yali Xiong5Xinyu Hu6Rahma Issa7Yixuan Zhu8Leyao Jia9Scott Barnett10Shengxia Yin11Chuanwu Zhu12Chao Wu13Mindie H. Nguyen14Jie Li15Department of Infectious DiseasesNanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese MedicineNanjingJiangsuChinaMAFLD Research CenterDepartment of Hepatologythe First Affiliated Hospital of Wenzhou Medical UniversityWenzhou Zhejiang ChinaDepartment of Hepatologythe Fifth People's Hospital of SuzhouSuzhouJiangsuChinaDepartment of Infectious DiseasesNanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese MedicineNanjingJiangsuChinaDepartment of Infectious DiseasesNanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese MedicineNanjingJiangsuChinaDepartment of Infectious DiseaseNanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsuChinaDepartment of Infectious DiseaseNanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsuChinaDepartment of Infectious DiseaseNanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsuChinaDepartment of Infectious DiseaseNanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsuChinaDepartment of Infectious DiseasesNanjing Drum Tower Hospital Clinical College of Nanjing Medical UniversityNanjingJiangsuChinaDivision of Gastroenterology and HepatologyStanford University Medical CenterPalo AltoCaliforniaUSADepartment of Infectious DiseaseNanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsuChinaDepartment of Hepatologythe Fifth People's Hospital of SuzhouSuzhouJiangsuChinaDepartment of Infectious DiseaseNanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsuChinaDivision of Gastroenterology and HepatologyStanford University Medical CenterPalo AltoCaliforniaUSADepartment of Infectious DiseasesNanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese MedicineNanjingJiangsuChinaABSTRACT Significant liver fibrosis is an indication for antiviral therapy in chronic hepatitis B (CHB). Using liver histology assessed by Scheuer system, we evaluated the diagnostic performance of PRO‐C3, GP73, and their combination for the presence of liver fibrosis, and compared them with FIB‐4, APRI, Agile 3+, FAST, and LSM in treatment‐naïve CHB patients from two centers. The study included 324 patients, of whom 167 had S2–4 (significant fibrosis) and 83 had S3–4 (advanced fibrosis). PRO‐C3 levels were higher in those with S2–4 and S3–4 compared with S0–1 and S0–2 (both p < 0.001), with similar findings for GP73. PRO‐C3 and GP73 were independently associated with S2–4 and S3–4 in multivariable analyses. The area under the curves (AUCs) of PRO‐C3 for S2–4 and S3–4 were 0.81 and 0.80, respectively, and exceeded those of GP73 (0.75 and 0.73). The combination of PRO‐C3 and GP73 also had significantly higher AUCs for both S2–4 (0.84 vs. 0.64) and S3–4 (0.80 vs. 0.65) as compared with FIB‐4, with similar findings for APRI, GP73, LSM, FAST, and Agile 3+ for S2–4. In conclusion, PRO‐C3 alone or in combination with GP73 is highly predictive for detecting significant liver fibrosis among CHB patients.https://doi.org/10.1002/mco2.70236biomarkerchronic hepatitis BGolgi protein 73liver fibrosisN‐terminal propeptide of type III collagen |
| spellingShingle | Qianqian Chen Ming‐Hua Zheng Li Zhu Fajuan Rui Wenjing Ni Yali Xiong Xinyu Hu Rahma Issa Yixuan Zhu Leyao Jia Scott Barnett Shengxia Yin Chuanwu Zhu Chao Wu Mindie H. Nguyen Jie Li Superior Diagnostic Efficacy of N‐Terminal Propeptide of Type III Collagen and Golgi Protein 73 for Detection of Fibrosis in Chronic Hepatitis B Patients MedComm biomarker chronic hepatitis B Golgi protein 73 liver fibrosis N‐terminal propeptide of type III collagen |
| title | Superior Diagnostic Efficacy of N‐Terminal Propeptide of Type III Collagen and Golgi Protein 73 for Detection of Fibrosis in Chronic Hepatitis B Patients |
| title_full | Superior Diagnostic Efficacy of N‐Terminal Propeptide of Type III Collagen and Golgi Protein 73 for Detection of Fibrosis in Chronic Hepatitis B Patients |
| title_fullStr | Superior Diagnostic Efficacy of N‐Terminal Propeptide of Type III Collagen and Golgi Protein 73 for Detection of Fibrosis in Chronic Hepatitis B Patients |
| title_full_unstemmed | Superior Diagnostic Efficacy of N‐Terminal Propeptide of Type III Collagen and Golgi Protein 73 for Detection of Fibrosis in Chronic Hepatitis B Patients |
| title_short | Superior Diagnostic Efficacy of N‐Terminal Propeptide of Type III Collagen and Golgi Protein 73 for Detection of Fibrosis in Chronic Hepatitis B Patients |
| title_sort | superior diagnostic efficacy of n terminal propeptide of type iii collagen and golgi protein 73 for detection of fibrosis in chronic hepatitis b patients |
| topic | biomarker chronic hepatitis B Golgi protein 73 liver fibrosis N‐terminal propeptide of type III collagen |
| url | https://doi.org/10.1002/mco2.70236 |
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