Gender-Specific Risk of Central Compartment Lymph Node Metastasis in Papillary Thyroid Carcinoma
Our aim was to evaluate the impact of gender on the predictive factors of central compartment lymph node metastasis (CLNM) in papillary thyroid carcinoma (PTC). A retrospective study of 590 patients treated for PTC was performed. Univariate and multivariate analyses showed that gender (female; P=0.0...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2018/6710326 |
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| author | Yushi Sun Hongjun Lv Shaoqiang Zhang Yanxia Bai Bingyin Shi |
| author_facet | Yushi Sun Hongjun Lv Shaoqiang Zhang Yanxia Bai Bingyin Shi |
| author_sort | Yushi Sun |
| collection | DOAJ |
| description | Our aim was to evaluate the impact of gender on the predictive factors of central compartment lymph node metastasis (CLNM) in papillary thyroid carcinoma (PTC). A retrospective study of 590 patients treated for PTC was performed. Univariate and multivariate analyses showed that gender (female; P=0.001), age (≥45 y; P<0.001), tumor size (>1 cm; P<0.001), and multifocality (P=0.004) were independent predictive factors of CLNM in PTC patients. Patients were divided into male group (n=152) and female group (n=438). Age (≥45 y; P=0.001), T4 (P=0.006) and multifocality (P=0.024) were independent predictive risk factors of CLNM in male patients. As for female patients, age (≥45 y; P<0.001), tumor size (>1 cm; P<0.001), multifocality (P=0.002), and microcalcification (P=0.027) were independently correlated with CLNM. The sensitivity of the multivariate model for predicting CLNM in male patients was 64.9%, specificity was 82.9%, and area under the ROC curve (AUC) was 0.764. As for female patients, the sensitivity was 55.7%, specificity was 77.9%, and AUC was 0.73. This study showed that the predictive factors of CLNM indeed varied according to gender. To have a more accurate evaluation of CLNM, different predictive systems should be used for male and female patients. |
| format | Article |
| id | doaj-art-9c4c4ef34dbc42cd9237fcfd58ba7893 |
| institution | OA Journals |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
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| series | International Journal of Endocrinology |
| spelling | doaj-art-9c4c4ef34dbc42cd9237fcfd58ba78932025-08-20T02:18:28ZengWileyInternational Journal of Endocrinology1687-83371687-83452018-01-01201810.1155/2018/67103266710326Gender-Specific Risk of Central Compartment Lymph Node Metastasis in Papillary Thyroid CarcinomaYushi Sun0Hongjun Lv1Shaoqiang Zhang2Yanxia Bai3Bingyin Shi4Department of Endocrinology, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaDepartment of Endocrinology, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaDepartment of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaDepartment of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaDepartment of Endocrinology, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaOur aim was to evaluate the impact of gender on the predictive factors of central compartment lymph node metastasis (CLNM) in papillary thyroid carcinoma (PTC). A retrospective study of 590 patients treated for PTC was performed. Univariate and multivariate analyses showed that gender (female; P=0.001), age (≥45 y; P<0.001), tumor size (>1 cm; P<0.001), and multifocality (P=0.004) were independent predictive factors of CLNM in PTC patients. Patients were divided into male group (n=152) and female group (n=438). Age (≥45 y; P=0.001), T4 (P=0.006) and multifocality (P=0.024) were independent predictive risk factors of CLNM in male patients. As for female patients, age (≥45 y; P<0.001), tumor size (>1 cm; P<0.001), multifocality (P=0.002), and microcalcification (P=0.027) were independently correlated with CLNM. The sensitivity of the multivariate model for predicting CLNM in male patients was 64.9%, specificity was 82.9%, and area under the ROC curve (AUC) was 0.764. As for female patients, the sensitivity was 55.7%, specificity was 77.9%, and AUC was 0.73. This study showed that the predictive factors of CLNM indeed varied according to gender. To have a more accurate evaluation of CLNM, different predictive systems should be used for male and female patients.http://dx.doi.org/10.1155/2018/6710326 |
| spellingShingle | Yushi Sun Hongjun Lv Shaoqiang Zhang Yanxia Bai Bingyin Shi Gender-Specific Risk of Central Compartment Lymph Node Metastasis in Papillary Thyroid Carcinoma International Journal of Endocrinology |
| title | Gender-Specific Risk of Central Compartment Lymph Node Metastasis in Papillary Thyroid Carcinoma |
| title_full | Gender-Specific Risk of Central Compartment Lymph Node Metastasis in Papillary Thyroid Carcinoma |
| title_fullStr | Gender-Specific Risk of Central Compartment Lymph Node Metastasis in Papillary Thyroid Carcinoma |
| title_full_unstemmed | Gender-Specific Risk of Central Compartment Lymph Node Metastasis in Papillary Thyroid Carcinoma |
| title_short | Gender-Specific Risk of Central Compartment Lymph Node Metastasis in Papillary Thyroid Carcinoma |
| title_sort | gender specific risk of central compartment lymph node metastasis in papillary thyroid carcinoma |
| url | http://dx.doi.org/10.1155/2018/6710326 |
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