Social Risk Profile and Cardiovascular‐Kidney‐Metabolic Syndrome in US Adults
Background Poor cardiovascular‐kidney‐metabolic (CKM) health is associated with premature mortality and excess morbidity in the United States. Adverse social conditions have a prominent impact on cardiometabolic diseases during the life course. We aim to examine the association between social risk p...
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Wiley
2024-08-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
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| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.124.034996 |
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| author | Jingkuo Li Lubi Lei Wei Wang Wenbo Ding Yanwu Yu Boxuan Pu Yue Peng Yinchu Li Lihua Zhang Yuanlin Guo |
| author_facet | Jingkuo Li Lubi Lei Wei Wang Wenbo Ding Yanwu Yu Boxuan Pu Yue Peng Yinchu Li Lihua Zhang Yuanlin Guo |
| author_sort | Jingkuo Li |
| collection | DOAJ |
| description | Background Poor cardiovascular‐kidney‐metabolic (CKM) health is associated with premature mortality and excess morbidity in the United States. Adverse social conditions have a prominent impact on cardiometabolic diseases during the life course. We aim to examine the association between social risk profile (SRP) and CKM multimorbidity among US adults. Methods and Results We used data from the National Health and Nutrition Examination Survey from 1999 to 2018. The definition of CKM syndrome is the coexistence of subclinical or clinical cardiovascular disease, chronic kidney disease, and metabolic disorders. We classified participants by 4 CKM stages according to the different clinical severity of different forms of CKM syndrome. We calculated the summed number of positive SRP measures, including employed, high‐income level, food secure, high education attainment, private insurance, owning a house, and married, as SRP scores and classified them into 4 levels by quartiles: low (0–2), lower‐middle (3–4), upper‐middle (5–6), and high (7–8). A total of 18 373 US adults, aged 20 to 79 years, were included in our analyses. There were 2567 (9.4%) participants with low SRP score level. Most individual SRP measures and a combined SRP score were associated with CKM stages. Compared with high SRP score level, low SRP level was associated with higher odds of having CKM stage 1 (odds ratio [OR], 1.34 [95% CI, 1.06–1.70]), CKM stage 2 (OR, 2.03 [95% CI, 1.59–2.58]), CKM stage 3 (OR, 5.28 [95% CI, 3.29–8.47]), and CKM stage 4 (OR, 5.97 [95% CI, 4.20–8.49]). Conclusions Cumulative social disadvantage, denoted by higher SRP burden, was associated with higher odds of CKM multimorbidity, independent of demographic and lifestyle factors. |
| format | Article |
| id | doaj-art-9c4af2951cf843eaa1d923101d5bd9e8 |
| institution | OA Journals |
| issn | 2047-9980 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj-art-9c4af2951cf843eaa1d923101d5bd9e82025-08-20T01:54:16ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802024-08-01131610.1161/JAHA.124.034996Social Risk Profile and Cardiovascular‐Kidney‐Metabolic Syndrome in US AdultsJingkuo Li0Lubi Lei1Wei Wang2Wenbo Ding3Yanwu Yu4Boxuan Pu5Yue Peng6Yinchu Li7Lihua Zhang8Yuanlin Guo9National Clinical Research Center for Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaNational Clinical Research Center for Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaNational Clinical Research Center for Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaCardio‐Metabolic Medicine Center, National Center for Cardiovascular Diseases, Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaNational Clinical Research Center for Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaNational Clinical Research Center for Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaNational Clinical Research Center for Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaNational Clinical Research Center for Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaNational Clinical Research Center for Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaCardio‐Metabolic Medicine Center, National Center for Cardiovascular Diseases, Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaBackground Poor cardiovascular‐kidney‐metabolic (CKM) health is associated with premature mortality and excess morbidity in the United States. Adverse social conditions have a prominent impact on cardiometabolic diseases during the life course. We aim to examine the association between social risk profile (SRP) and CKM multimorbidity among US adults. Methods and Results We used data from the National Health and Nutrition Examination Survey from 1999 to 2018. The definition of CKM syndrome is the coexistence of subclinical or clinical cardiovascular disease, chronic kidney disease, and metabolic disorders. We classified participants by 4 CKM stages according to the different clinical severity of different forms of CKM syndrome. We calculated the summed number of positive SRP measures, including employed, high‐income level, food secure, high education attainment, private insurance, owning a house, and married, as SRP scores and classified them into 4 levels by quartiles: low (0–2), lower‐middle (3–4), upper‐middle (5–6), and high (7–8). A total of 18 373 US adults, aged 20 to 79 years, were included in our analyses. There were 2567 (9.4%) participants with low SRP score level. Most individual SRP measures and a combined SRP score were associated with CKM stages. Compared with high SRP score level, low SRP level was associated with higher odds of having CKM stage 1 (odds ratio [OR], 1.34 [95% CI, 1.06–1.70]), CKM stage 2 (OR, 2.03 [95% CI, 1.59–2.58]), CKM stage 3 (OR, 5.28 [95% CI, 3.29–8.47]), and CKM stage 4 (OR, 5.97 [95% CI, 4.20–8.49]). Conclusions Cumulative social disadvantage, denoted by higher SRP burden, was associated with higher odds of CKM multimorbidity, independent of demographic and lifestyle factors.https://www.ahajournals.org/doi/10.1161/JAHA.124.034996cardiovascular‐kidney‐metabolic healthcross‐sectional studymultimorbiditysocioeconomic factors |
| spellingShingle | Jingkuo Li Lubi Lei Wei Wang Wenbo Ding Yanwu Yu Boxuan Pu Yue Peng Yinchu Li Lihua Zhang Yuanlin Guo Social Risk Profile and Cardiovascular‐Kidney‐Metabolic Syndrome in US Adults Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease cardiovascular‐kidney‐metabolic health cross‐sectional study multimorbidity socioeconomic factors |
| title | Social Risk Profile and Cardiovascular‐Kidney‐Metabolic Syndrome in US Adults |
| title_full | Social Risk Profile and Cardiovascular‐Kidney‐Metabolic Syndrome in US Adults |
| title_fullStr | Social Risk Profile and Cardiovascular‐Kidney‐Metabolic Syndrome in US Adults |
| title_full_unstemmed | Social Risk Profile and Cardiovascular‐Kidney‐Metabolic Syndrome in US Adults |
| title_short | Social Risk Profile and Cardiovascular‐Kidney‐Metabolic Syndrome in US Adults |
| title_sort | social risk profile and cardiovascular kidney metabolic syndrome in us adults |
| topic | cardiovascular‐kidney‐metabolic health cross‐sectional study multimorbidity socioeconomic factors |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.124.034996 |
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