The nucleic acid reactions on the nanomaterials surface for biomedicine
Abstract Integrating nucleic acids (NAs) with nanomaterials has substantially advanced biomedical research, enabling critical applications in biosensing, drug delivery, therapeutics, and the synthesis of nanomaterials. At the core of these advances are the reactions of NAs on nanomaterial surfaces,...
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| Format: | Article |
| Language: | English |
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BMC
2025-04-01
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| Series: | Journal of Nanobiotechnology |
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| Online Access: | https://doi.org/10.1186/s12951-025-03374-2 |
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| author | Zhenrui Xue Lu Wang Shengnan Pan Jie Yan Minli You Chunyan Yao |
| author_facet | Zhenrui Xue Lu Wang Shengnan Pan Jie Yan Minli You Chunyan Yao |
| author_sort | Zhenrui Xue |
| collection | DOAJ |
| description | Abstract Integrating nucleic acids (NAs) with nanomaterials has substantially advanced biomedical research, enabling critical applications in biosensing, drug delivery, therapeutics, and the synthesis of nanomaterials. At the core of these advances are the reactions of NAs on nanomaterial surfaces, encompassing conjugation (covalent and non-covalent), detachment (physical and chemical), and signal amplification (enzyme-mediated signal amplification, enzyme-free signal amplification, and DNA Walker). Here, we review the fundamental mechanisms and recent progress in nucleic acid reactions on nanomaterial surfaces, discuss emerging applications for diagnostics, nanomedicine, and gene therapy, and explore persistent challenges in the field. We offer a forward-looking perspective on how future developments could better control, optimize, and harness these reactions for transformative advances in nanomedicine and biomedical engineering. Graphical abstract |
| format | Article |
| id | doaj-art-9c48afe78cfb4a8c94343a15031a08d6 |
| institution | DOAJ |
| issn | 1477-3155 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj-art-9c48afe78cfb4a8c94343a15031a08d62025-08-20T03:15:14ZengBMCJournal of Nanobiotechnology1477-31552025-04-0123113110.1186/s12951-025-03374-2The nucleic acid reactions on the nanomaterials surface for biomedicineZhenrui Xue0Lu Wang1Shengnan Pan2Jie Yan3Minli You4Chunyan Yao5Department of Transfusion Medicine, Southwest Hospital, Third Military Medical University (Army Medical University)Department of Transfusion Medicine, Southwest Hospital, Third Military Medical University (Army Medical University)Department of Transfusion Medicine, Southwest Hospital, Third Military Medical University (Army Medical University)Department of Transfusion Medicine, Southwest Hospital, Third Military Medical University (Army Medical University)The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong UniversityDepartment of Transfusion Medicine, Southwest Hospital, Third Military Medical University (Army Medical University)Abstract Integrating nucleic acids (NAs) with nanomaterials has substantially advanced biomedical research, enabling critical applications in biosensing, drug delivery, therapeutics, and the synthesis of nanomaterials. At the core of these advances are the reactions of NAs on nanomaterial surfaces, encompassing conjugation (covalent and non-covalent), detachment (physical and chemical), and signal amplification (enzyme-mediated signal amplification, enzyme-free signal amplification, and DNA Walker). Here, we review the fundamental mechanisms and recent progress in nucleic acid reactions on nanomaterial surfaces, discuss emerging applications for diagnostics, nanomedicine, and gene therapy, and explore persistent challenges in the field. We offer a forward-looking perspective on how future developments could better control, optimize, and harness these reactions for transformative advances in nanomedicine and biomedical engineering. Graphical abstracthttps://doi.org/10.1186/s12951-025-03374-2NanomaterialsInteractionNA reactionsSurface chemistryNanomedicineGene therapy |
| spellingShingle | Zhenrui Xue Lu Wang Shengnan Pan Jie Yan Minli You Chunyan Yao The nucleic acid reactions on the nanomaterials surface for biomedicine Journal of Nanobiotechnology Nanomaterials Interaction NA reactions Surface chemistry Nanomedicine Gene therapy |
| title | The nucleic acid reactions on the nanomaterials surface for biomedicine |
| title_full | The nucleic acid reactions on the nanomaterials surface for biomedicine |
| title_fullStr | The nucleic acid reactions on the nanomaterials surface for biomedicine |
| title_full_unstemmed | The nucleic acid reactions on the nanomaterials surface for biomedicine |
| title_short | The nucleic acid reactions on the nanomaterials surface for biomedicine |
| title_sort | nucleic acid reactions on the nanomaterials surface for biomedicine |
| topic | Nanomaterials Interaction NA reactions Surface chemistry Nanomedicine Gene therapy |
| url | https://doi.org/10.1186/s12951-025-03374-2 |
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